Tissue accumulation of polystyrene microplastics causes oxidative stress, hepatopancreatic injury and metabolome alterations in Litopenaeus vannamei

Zeng, Yingxu; Deng, Baichuan; Kang, Zixin; Araújo, Pedro Henrique Hermes de; Mjøs, Svein A.; Liu, Ruina; Lin, Jenshan; Yang, Tao

doi:10.1016/j.ecoenv.2023.114871

Cited by 18 publications

(3 citation statements)

References 70 publications

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“…Exposure to PS MPs caused evident metabolic alterations in the hepatopancreas of L. vannamei, depending on PS MP concentrations. Overall, metabolic pathway analysis conducted in this study revelaed that PS MP exposure interfered with hepatopancreatic metabolism of crustaceans, even at a very low exposure level, mainly affecting glycolysis, lipolysis, and amino acid metabolism [125]. Furthermore, evidence was reported about the potential of PS MPs to alter the energy metabolism and osmotic adjustment pathway in the gills of Pacific oyster C. gigas exposed to 1 × 10 4 /L spherical PS MPs of different sizes (small PS MPs 6 µm, large PS MPs 0-60 µm) under three salinity levels (21,26, and 31 practical salinity units (psu)) for 14 days [123].…”

Section: Effects Of Ps Mnps On the Metabolome Of Aquatic Invertebratesmentioning

confidence: 69%

“…The effects of PS MPs were also evaluated on another invertebrate organism, the shrimp L. vannamei, exposed to a range of microplastics from 0.02 to 1 mg/L, using the LC-MS/MS metabolomic approach [125]. Exposure to PS MPs caused evident metabolic alterations in the hepatopancreas of L. vannamei, depending on PS MP concentrations.…”

Section: Effects Of Ps Mnps On the Metabolome Of Aquatic Invertebratesmentioning

confidence: 99%

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Polystyrene Micro- and Nanoplastics (PS MNPs): A Review of Recent Advances in the Use of -Omics in PS MNP Toxicity Studies on Aquatic Organisms

Eliso,

Billè,

Cappello

et al. 2024

Fishes

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In recent years, micro- and nanoplastics (MNPs) have represented an emerging threat for the aquatic environment due to their persistence and widespread distribution. Indeed, their small size and increased surface area lead to a high biological reactivity, which can be crucial for the health status of biota. To date, several studies have investigated lethal and sublethal endpoints of MNPs, while one of the main challenges is to understand their mechanisms of toxicity in a comprehensive manner. With this aim, the field of aquatic ecotoxicology can now benefit from the -omics approaches. This review focuses on the recent advances related to the use of transcriptomics, proteomics, and metabolomics to deeply investigate the molecular and biochemical responses of aquatic organisms, both fishes and aquatic invertebrates, to pristine polystyrene (PS) MNPs. The literature reviewed revealed that transcriptomics and metabolomics are the most frequently used -omic approaches. Overall, the studies taken into consideration shed light on the events triggered by PS MNPs at molecular and cellular levels, identifying as mechanisms of toxicity the pathways involved in oxidative stress, energy metabolism, immune response, and the nervous system. Future studies should therefore focus on the use and integration of multi-omics approaches for a more comprehensive understanding of the mechanisms involved in MNPs toxicity.

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Section: Effects Of Ps Mnps On the Metabolome Of Aquatic Invertebratesmentioning

confidence: 69%

Section: Effects Of Ps Mnps On the Metabolome Of Aquatic Invertebratesmentioning

confidence: 99%

Polystyrene Micro- and Nanoplastics (PS MNPs): A Review of Recent Advances in the Use of -Omics in PS MNP Toxicity Studies on Aquatic Organisms

Eliso,

Billè,

Cappello

et al. 2024

Fishes

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“…Plastic particles have emerged as a brand-new class of environmental contaminants that can build up in a variety of tissues and organs [151], producing ROS and triggering OS (Table 2) [34,37,138,145,[152][153][154][155][156][157]. For examples, damage to the liver and pancreas in Lithopenaeus vannamei resulted from an imbalance in the antioxidant system, and this damage worsened as the MP concentration increased (PS; 2 µm; 0.02, 0.2, and 1 mg/L) [157].…”

Section: Effects Of Mp-induced Oxidative Stress On Tissues and Organsmentioning

confidence: 99%

Microplastics and Oxidative Stress—Current Problems and Prospects

Kadac-Czapska,

Ośko,

Knez

et al. 2024

Antioxidants

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Microplastics (MPs) are plastic particles between 0.1 and 5000 µm in size that have attracted considerable attention from the scientific community and the general public, as they threaten the environment. Microplastics contribute to various harmful effects, including lipid peroxidation, DNA damage, activation of mitogen-activated protein kinase pathways, cell membrane breakages, mitochondrial dysfunction, lysosomal defects, inflammation, and apoptosis. They affect cells, tissues, organs, and overall health, potentially contributing to conditions like cancer and cardiovascular disease. They pose a significant danger due to their widespread occurrence in food. In recent years, information has emerged indicating that MPs can cause oxidative stress (OS), a known factor in accelerating the aging of organisms. This comprehensive evaluation exposed notable variability in the reported connection between MPs and OS. This work aims to provide a critical review of whether the harmfulness of plastic particles that constitute environmental contaminants may result from OS through a comprehensive analysis of recent research and existing scientific literature, as well as an assessment of the characteristics of MPs causing OS. Additionally, the article covers the analytical methodology used in this field. The conclusions of this review point to the necessity for further research into the effects of MPs on OS.

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