Tissue alloantigens in humans

Dausset, J; Iványi, P; Iványi, Dagmar

doi:10.1097/00007890-196601000-00021

Cited by 30 publications

(22 citation statements)

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“…Other studies still being continued show that kidneys from HL-A identical donors require less immunosuppression and function better than unrelated grafts (5) and that ordinarily, a bone marrow graft from an HL-A-identical donor offers the best possibilities for a replacement therapy [19][20][21]. These associations are all firmly based and the original conclusion was that HL-A (or Hu 1 as it was first called) was the major histocompatibility locus [1,12,22,23]. The description as given at that time, was of a locus of 15 or more alleles that control MLR, serologic specificities, and transplantation antigens [1,2].…”

Section: Discussionmentioning

confidence: 99%

Three Closely Linked Genetic Systems Relevant to Transplantation

Yunis

Amos

1971

Proc. Natl. Acad. Sci. U.S.A.

271

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The concept that antigens of a major histocompatibility locus (HL-A), the mixed leukocyte reaction, and the rejection of a graft are expressions of the same genetic region has been generally accepted.We have presented experiments that challenge the above concept and suggest that the rejection time of skin and organ transplants is dependent on immunization against the products of two, and possibly three, separate, but closely linked, genetic systems: HL-A, mixed leukocyte reaction (MLR-S), and hypersensitivity delayed reaction (HDR).The findings presented and discussed here suggest that the HL-A antigens are not the primary factors involved in the cell-mediated component of allotransplantation, and that these antigens and phenotypes of the mixed leukocyte reaction can only be used as a guide in predicting the survival of allografts that are obtained from unrelated donors.

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Section: Discussionmentioning

confidence: 99%

Three Closely Linked Genetic Systems Relevant to Transplantation

Yunis

Amos

1971

Proc. Natl. Acad. Sci. U.S.A.

271

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“…The role of leucocyte group antigens in skin transplantation was conclusively demonstrated in 1965,14,15 by the use of leucocyte group-incompatible skin allografts applied to recipients previously immunized against the same major leucocyte group antigen(s). By this technic, Antigens 1(Mac), 3(4a), and 7(4b) regularly induced accelerated or white graft rejection of skin allografts incompatible for such groups in pretreated subjects negative for those groups.…”

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confidence: 99%

Serologic Factors In Human Transplantation

et al. 1967

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“…The genetic loci of the major histocompatibility antigens in man have now been identified and partially defined utilizing serologic techniques (3)(4)(5)(6). Present data indicate that this antigenic system designated HL-A, is controlled by two closely linked polymorphic loci on a single pair of autosomal chromosomes.…”

Section: Introductionmentioning

confidence: 99%

Renal Transplantation between HL-A Identical Donor-Recipient Pairs

Hf¹,

Gunnells²,

Rr³

et al. 1972

J. Clin. Invest.

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A B S T R A C T 16 patients underwent renal transplanitation from a sibling donor who was prospectively determiiined to be ABO compatible and HL-A identical with the recipient. Unidirectional mixed leukocyte reactions were performed; in each instance, lymphocyte stimulation in either directi.on was not observed.The plasma creatinine 10-68 months after transplantation in these 16 patients ranged between 0.9 and 1.9 mg/ 100 ml. The creatinine clearance ranged from 48 to 113 ml/min, and the blood urea nitrogen (BUN) ranged between 12 and 35 mg/100 ml. Urine protein excretion varied from 0.11 to 1.86 g/day. Six patients exhibited no detectable clinical episodes of acute rejection; they were treated with azathioprine alone and each of them demonstrated normal or near normal renal histology when biopsy specimens were obtained more than 6 months after transplantation. Nine patients experienced acute rejection episodes that required the use of steroid therapy. The severity of these rejection episodes was variable; they included a mild reduction in renal function with an immediate steroid-induced restorationi of function anid eventual discontinuance of steroid therapy to severe reduction in function requiring prolonged and moderate doses of steroids without return to normal renal function. Renal histological observations in this group ranged from mild to marked cellular and structural changes which fit the criteria of the rejection. One patient demonstrated a gradual loss of renal function with heavy proteinuria. Biopsy of this allograft demonstrated the recurrence of original disease. i.e.. lobular glomerulonephritis.

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Tissue alloantigens in humans

Cited by 30 publications

References 0 publications

Three Closely Linked Genetic Systems Relevant to Transplantation

Three Closely Linked Genetic Systems Relevant to Transplantation

Serologic Factors In Human Transplantation

Renal Transplantation between HL-A Identical Donor-Recipient Pairs

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