Tissue and Cell Reaction of the Synovial Media to Intraarticular Injection of Polymer Viscoprosthesis “Noltrex” in Experimental Conditions

Abstract

ЗАО Научный центр «Биоформ», МоскваИзучена реакция синовиальной оболочки и хряща 20 кроликов на введение 1 мл полимерного геля «Нол-трекс» в полость скакательного сустава. Сделан вывод о биологической инертности и безопасности нолтрекса при его введении в полость сустава.Ключевые слова: остеоартрит, остеоартроз, синовиальная жидкость, полиакриламидный гель, нолтрекс. Reaction of synovial membrane and cartilage on 1 ml of polymer gel «NOLTREX» injected into the cavity of jumping joint of 20 rabbits was investigated. Biological inertness and safety of noltrex injected into the joint cavity was established. TISSUE AND CELL REACTION OF THE SYNOVIAL MEDIA TO INTRAARTICULAR INJECTION OF POLYMER VISCOPROSTHESIS "NOLTREX" IN EXPERIMENTAL CONDITIONS A.B. Shekhter

Equine Musculoskeletal Pathologies: Clinical Approaches and Therapeutical Perspectives—A Review

“…PHyds have appeared more recently than HyA, and is a 100% synthetic product, are non-soluble, and essentially act as a substitute for SF, increasing joint lubrication and consequently joint pain/inflammation, thus improving joint function. In an in vivo study with rabbits, it was possible to detect the presence of the hydrogel in the joint cartilage space at day 60 after one single dose treatment [121]. The efficacy of PHyd can be possibly explained because its molecular weight is three times greater than HyA, thus preventing the degenerative process caused by the inflammatory cytokines present in the SF of the joints [122].…”