Tissue-Based Immunohistochemical Markers for Diagnosis and Classification of Renal Cell Carcinoma

Qu, Liang G.; Thirugnanasundralingam, Vaisnavi; Bolton, Damien; Finelli, Antonio; Lawrentschuk, Nathan

doi:10.48083/mqye9599

“…Bilateral radical nephrectomy with Metastasectomy (Pneumonectomy) is an even uncommonly done procedure in renal failure patients on dialysis. HRTS (Hereditary renal tumor syndrome) must be suspected in patients with multiple renal tumours, bilateral renal negative, but positive for progesterone receptors is the pattern for onchocytoma [23][24][25][26]. These patterns of immunohistochemical markers formed the basis of our specimen processing and reporting.…”

Section: Discussionmentioning

confidence: 99%

A Rare Presentation of Bilateral Multifocal and Multitype Renal Cell Carcinoma in End Stage Renal Disease

Kabilan,

Edwin,

Seethalakshmi

et al. 2024

Int Arch Urol Complic

0

View full text Add to dashboard Cite

Introduction: Renal cell carcinoma (RCC) is the most common tumour of the kidney. The common histological subtypes are clear cell, papillary and chromophobe renal cell carcinomas. This case has several unique features, which makes it a rare presentation. The most important unique fact is the presence of all the three common histological types of renal cell carcinoma in the same patient, which is a rarity.Presentation: 63-years-old male from Tanzania with End Stage Renal Disease came to hospital for Live Donor renal transplantation. Incidental detection of left renal tumor of size 3 cm diameter in the lower pole of kidney was made. He underwent laparoscopic radical nephrectomy. The histopathology was clear cell renal cell carcinoma. He came back later after 3 years with persistent cough. On evaluation was found to have a 5 cm pulmonary metastasis and two tumors in the upper pole of right kidney. One of the tumours was 3 cm and was solid and the other was 2.5 cm complex cystic tumor. Laparoscopic right radical nephrectomy with partial pneumonectomy was done. Histopathology was papillary renal cell carcinoma in the cystic renal tumor and pulmonary metastasis. Chromophobe renal cell carcinoma reported in the solid renal tumor. The following immunohistochemical markers were used in the sub typing: Cytokeratin 7, vimentin and progesterone receptor. Conclusion:Multitype and multifocal renal cell carcinoma though rare we may come across them. In these situations, it is prudent to suspect HRTS (Hereditary renal tumor syndrome). If these patients are on hemodialysis with ESRD a radical nephrectomy would be better option than partial nephrectomy. B/L radical nephrectomy in ESRD patients can be done in patients with good vascular access.

show abstract

“…Bilateral radical nephrectomy with Metastasectomy (Pneumonectomy) is an even uncommonly done procedure in renal failure patients on dialysis. HRTS (Hereditary renal tumor syndrome) must be suspected in patients with multiple renal tumours, bilateral renal negative, but positive for progesterone receptors is the pattern for onchocytoma [23][24][25][26]. These patterns of immunohistochemical markers formed the basis of our specimen processing and reporting.…”

Section: Discussionmentioning

confidence: 99%

Untitled

2024

Int Arch Urol Complic

0

View full text Add to dashboard Cite

Introduction: Renal cell carcinoma (RCC) is the most common tumour of the kidney. The common histological subtypes are clear cell, papillary and chromophobe renal cell carcinomas. This case has several unique features, which makes it a rare presentation. The most important unique fact is the presence of all the three common histological types of renal cell carcinoma in the same patient, which is a rarity.Presentation: 63-years-old male from Tanzania with End Stage Renal Disease came to hospital for Live Donor renal transplantation. Incidental detection of left renal tumor of size 3 cm diameter in the lower pole of kidney was made. He underwent laparoscopic radical nephrectomy. The histopathology was clear cell renal cell carcinoma. He came back later after 3 years with persistent cough. On evaluation was found to have a 5 cm pulmonary metastasis and two tumors in the upper pole of right kidney. One of the tumours was 3 cm and was solid and the other was 2.5 cm complex cystic tumor. Laparoscopic right radical nephrectomy with partial pneumonectomy was done. Histopathology was papillary renal cell carcinoma in the cystic renal tumor and pulmonary metastasis. Chromophobe renal cell carcinoma reported in the solid renal tumor. The following immunohistochemical markers were used in the sub typing: Cytokeratin 7, vimentin and progesterone receptor. Conclusion:Multitype and multifocal renal cell carcinoma though rare we may come across them. In these situations, it is prudent to suspect HRTS (Hereditary renal tumor syndrome). If these patients are on hemodialysis with ESRD a radical nephrectomy would be better option than partial nephrectomy. B/L radical nephrectomy in ESRD patients can be done in patients with good vascular access.

show abstract

Differential immunohistochemical expression of Galectin-1 and Galectin-3 in renal cell carcinoma

Ahmed,

Alsedfy,

Taha

et al. 2024

Egypt J Pathol

0

View full text Add to dashboard Cite

Background Renal cell carcinoma (RCC) is a heterogeneous cancer with many histological and molecular subtypes. Many new potential diagnostic, prognostic, and predictive biomarkers are still emerging. RCC treatment approaches are plentiful, including surgical resection, ablation, and active surveillance as well as immunotherapy. However, many cases are nonresponsive to such modalities and others experience recurrence or metastatic disease. Accordingly, the research work nowadays is concerned with looking for new targeted therapy biomarkers to treat RCC. Galectin-1 and Galectin-3 are the proposed biomarkers for this issue. Aim and methods This work aims to review the expression of Galectin-1 and Galectin-3 immune markers among the main histological subtypes of RCC and their correlation with clinicopathological parameters. To carry out this work, 60 cases of RCC were included in this study: 36 clear RCC, 16 papillary RCC I and II, and eight cases chromophobe RCC. Results Galectin-1 was highly expressed in 42 out of 60 cases, while Galectin-3 was highly expressed in only 13 cases. There was a statistically significant association between Galectin-1 and Galectin-3 expression and the histological subtype being expressed more in chromophobe subtype rather than others. There was a statistically significant inverse association between Galectin-1 expression and lymphovascular invasion as well as Galectin-3 expression and tumor necrosis and hemorrhage. There was no statistically significant association between Galectin-1 and 3 and the remaining clinicopathological parameters. Conclusion Galectin-1 and Galectin-3 could be used as potential diagnostic markers for chromophobe RCC as they are highly expressed in this subtype in comparison to others and can be used as targeted biomarkers for RCC therapy in the future. Galectin-3 has an anti-necrotic role and this could lead to chemotherapy resistance.

show abstract

Tissue-Based Immunohistochemical Markers for Diagnosis and Classification of Renal Cell Carcinoma

Cited by 3 publications

References 84 publications

A Rare Presentation of Bilateral Multifocal and Multitype Renal Cell Carcinoma in End Stage Renal Disease

A Rare Presentation of Bilateral Multifocal and Multitype Renal Cell Carcinoma in End Stage Renal Disease

Untitled

Differential immunohistochemical expression of Galectin-1 and Galectin-3 in renal cell carcinoma

Contact Info

Product

Resources

About