Tissue carcinoembryonic antigen and dna aneuploidy in precancerous and cancerous colorectal lesions

Fischbach, Wolfgang; Mössner, Joachim; Seyschab, Helga; Höhn, H

doi:10.1002/1097-0142(19900415)65:8<1820::aid-cncr2820650826>3.0.co;2-z

Cited by 25 publications

(8 citation statements)

References 33 publications

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“…The relationship between them, however, is still not settled. Some studies have demonstrated a significant association between the two markers (Hammarberg et al, 1984;Melville et al, 1988), whereas in other reports, no relationship was found Fischbach et al, 1990). In the present study, we could demonstrate no significant association between DNA ploidy pattern and dysplasia.…”

Section: Discussioncontrasting

confidence: 75%

“…Aneuploid cell populations have previously been found by DNA flow cytometry in the colonic mucosa of patients with ulcerative colitis, both preceding and coexistent with colonic carcinomas. Diverging results have been reported, however, both with regard to the proportion of aneuploid carcinomas in patients with ulcerative colitis, as well as the relationship between dysplasia and aneuploidy in tumour-distant flat mucosa (Hammarberg et al, 1984, L0fberg et al, 1987, Melville et al, 1988, Fischbach et al, 1990). …”

mentioning

confidence: 99%

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Flow cytometric DNA ploidy pattern in dysplastic mucosa, and in primary and metastatic carcinomas in patients with longstanding ulcerative colitis

Meling

Clausen²,

Bergan³

et al. 1991

Br J Cancer

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Section: Discussioncontrasting

confidence: 75%

mentioning

confidence: 99%

Flow cytometric DNA ploidy pattern in dysplastic mucosa, and in primary and metastatic carcinomas in patients with longstanding ulcerative colitis

Meling

Clausen²,

Bergan³

et al. 1991

Br J Cancer

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“…As an example, intestinal bowel disease is an autoimmune disease that is characterized by a non-limited inflammation in the gut and elevated CEA expression in the inflammatory lesion. 16,17 Due to the chronic inflammatory process, intestinal bowel disease is thought to be a precancerosis with the therapeutic need to repress the ongoing inflammatory process. The latter is currently aimed to be achieved by the systemic application of non-steroid antiphlogistic drugs, however, with remarkable systemic site effects.…”

Section: Discussionmentioning

confidence: 99%

Redirecting human CD4+CD25+ regulatory T cells from the peripheral blood with pre-defined target specificity

Hombach¹,

Kofler²,

Rappl³

et al. 2009

Gene Ther

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Recent insight into the balance of self-tolerance and autoaggression has raised interest in using human regulatory T (Treg) cells for adoptive immunotherapy of unlimited autoimmune diseases including type-1 diabetes, rhematoid arthritis and multiple sclerosis. The therapeutic use of Treg cells, however, is so far hampered by the inefficiency of current protocols in making them accessible for genetic manipulations. We report here that TCR/CD3 stimulation that is accompanied by extensive CD28 costimulation makes human Treg cells susceptible to retroviral gene transfer ex vivo while preserving their properties in vitro and in vivo.

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“…Ulcerative Colitis Multiple reports have shown that DNA aneuploidy may be found in dysplastic epithelium in ulcerative colitis (UC) and DNA aneuploidy may often precede cancer in UC (45)(46)(47)(48)(49). It has therefore been suggested that FCM may help to identify the UC patients who are in greatest need of surveillance endoscopy.…”

Section: Future Directionsmentioning

confidence: 99%

Consensus review of the clinical utility of dna flow cytometry in colorectal cancer

Bauer¹,

Bagwell²,

Giaretti

et al. 1993

Cytometry

103

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It is estimated that in 1993 there will be > 155,000 new cases of adenocarcinoma of the colon and rectum in the United States (1). Surgical resectability offers the best chance of cure, and the results of surgical and pathologic staging are important factors in deciding whether the patient should be offered adjuvant chemotherapy in the case of colon cancer or combined chemotherapy and radiation therapy for patients with rectal cancer. Because there is significant variation in the rate of recurrence and overall survival within TNM stage categories, there is a need for additional, independent factors to better predict outcome in patients that have had a potentially curative surgical resection.To assess the available data on the possible clinical utility of DNA flow cytometry, a Consensus Conference was recently held. The aims of this work, which reports the conclusions from the ColodRectum Organ System Group that participated in the conference, are: (1) to analyze the current published literature regarding the clinical utility of flow cytometric measurements of DNA ploidy and cell proliferative activity (PA, based on %S or %S + G2M) as prognostic factors for recurrence and survival, and (2) to suggest guidelines and standards for future investigation of DNA ploidy and PA so that these measurements can be appropriately applied to specific colorectal cancer patient care situations.The majority of studies in the literature (2-23; Table 1) suggest that DNA ploidy has significant prognostic value. There are no reports demonstrating DNA aneuploidy as a favorable feature, but several reports (e.g., 3,7,14,18,19,20,21,24) have concluded that DNA ploidy provides no additional significant prognostic information, particularly when considered following multivariate analysis that includes traditional prognostic factors. With exceptions (e.g., 7,17,25), most studies suggest a trend toward an increasing frequency of DNA aneuploidy in higher Dukes stages and for tumors located in the left colon and rectum. Although there are exceptions, most of the published studies suggest that DNA ploidy and PA are unrelated to numerous clinical and pathologic observations in colorectal cancers (26). These include evaluation of age, tumor grade, infiltrative growth pattern, host inflammatory and desmoplastic response, presence of vascular invasion, carcinoembryonic antigen, or mutant p53 status. Fewer studies have examined the prognostic significance of PA. As summarized in Table 2, these series with one exception (7) have found PA to be a significant prognostic factor in colorectal cancer. These conclusions were reached despite the use of four different mathematical methods for S-phase modeling, some with debris subtraction and some without. This emphasizes the need for careful methodological description and, wherever possible, standardization of methods as described subsequently.Contradictory study results have been obtained following the use of a wide variety of technical and analytical methods, many of which may compromise the accurate det...

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Tissue carcinoembryonic antigen and dna aneuploidy in precancerous and cancerous colorectal lesions

Cited by 25 publications

References 33 publications

Flow cytometric DNA ploidy pattern in dysplastic mucosa, and in primary and metastatic carcinomas in patients with longstanding ulcerative colitis

Flow cytometric DNA ploidy pattern in dysplastic mucosa, and in primary and metastatic carcinomas in patients with longstanding ulcerative colitis

Redirecting human CD4+CD25+ regulatory T cells from the peripheral blood with pre-defined target specificity

Consensus review of the clinical utility of dna flow cytometry in colorectal cancer

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