Tissue Chemoablation

Rehman, Jamil; Landman, Jaime; Sundaram, Chandrum; Clayman, Ralph V.

doi:10.1089/089277903322518662

Cited by 12 publications

(6 citation statements)

References 128 publications

(124 reference statements)

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“…Alternatively, these chemokines can recruit immune cells, as neutrophils, dendritic cells (DCs), myeloid derived suppressor cells (MDSCs) and TAMs [ 55 , 56 , 57 ] able to secrete angiogenic factors [ 39 , 58 , 59 ]. MDSCs and TAMs can even adopt endothelial cell features, contributing to vessel formation [ 60 ].…”

Section: Chemokines and Cancermentioning

confidence: 99%

Role of Chemokines in the Biology of Cholangiocarcinoma

Caligiuri

Pastore

Lori

et al. 2020

Cancers

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Cholangiocarcinoma (CCA), a heterogeneous tumor with poor prognosis, can arise at any level in the biliary tree. It may derive from epithelial cells in the biliary tracts and peribiliary glands and possibly from progenitor cells or even hepatocytes. Several risk factors are responsible for CCA onset, however an inflammatory milieu nearby the biliary tree represents the most common condition favoring CCA development. Chemokines play a key role in driving the immunological response upon liver injury and may sustain tumor initiation and development. Chemokine receptor-dependent pathways influence the interplay among various cellular components, resulting in remodeling of the hepatic microenvironment towards a pro-inflammatory, pro-fibrogenic, pro-angiogenic and pre-neoplastic setting. Moreover, once tumor develops, chemokine signaling may influence its progression. Here we review the role of chemokines in the regulation of CCA development and progression, and the modulation of angiogenesis, metastasis and immune control. The potential role of chemokines and their receptors as possible biomarkers and/or therapeutic targets for hepatobiliary cancer is also discussed.

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Section: Chemokines and Cancermentioning

confidence: 99%

Role of Chemokines in the Biology of Cholangiocarcinoma

Caligiuri

Pastore

Lori

et al. 2020

Cancers

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“…A recent Medline search by Rehman et al 24 . indicated that chemoablation was commonly used for liver metastases.…”

Section: Discussionmentioning

confidence: 99%

Effects of direct injection of dehydrated ethanol on PC3 human prostate cancer cells in nude mice: Preliminary study

et al. 2007

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Objectives:The effect of direct local injection of dehydrated ethanol on hormone-independent prostatic carcinoma cells (PC3 cells) implanted in nude mice was investigated. Methods: PC3 tumors were implanted subcutaneously into 30 nude mice. Three weeks later, dehydrated ethanol was injected directly into the tumors. Twenty-three animals received an injection of ethanol at a volume of 40 mL, 80 mL, or 160 mL, and were divided into a low-dose group (n = 11) and a high-dose group (n = 12) on the basis of the ethanol/tumor volume ratio (<30% versus Ն30%). The control group (n = 7) was injected with 40 mL of physiological saline. The tumor volume before treatment was 324.9 Ϯ 110.9 mm 3 and was assessed as well as 1 day, 4 days, 1 week, 2 weeks, and 3 weeks after injection. Then the changes of tumor volume were compared between the two ethanol groups (low-dose group and high-dose group) and the control group. Histological examination was performed for up to 3 weeks after injection. Results: Assessment of tumor volume showed that the ethanol/tumor volume ratio was 16.1 Ϯ 5.3% in the low-dose group (n = 5) and 51.8 Ϯ 20.3% in the high-dose group (n = 6). Tumor growth was significantly inhibited after 1 and 2 weeks in the ethanol groups compared with the control group (n = 3). After 3 weeks, there was a tendency for tumor regrowth in the low-dose group, but growth inhibition was maintained in the high-dose group. Histological examination showed tumor degeneration and necrosis with feeding vessel obstruction in the acute phase. Conclusions: Local injection of dehydrated ethanol regressed tumors of prostatic carcinoma cells in nude mice, with the degeneration of tumor cells and occlusion of feeding vessels.

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“…The drug formulation was administered on the tumour site, and as observed by the re-evaluation of the authors, was efficiently used. In the review paper by Rehman et al, 14 a wide search since 1965–2003 was performed regarding tissue chemoablation. The review reviewed articles regarding both in vitro and in vivo experiments, and the data included were regarding the following: 95% ethanol (4 ml), 24% hypertonic saline (4 ml) or 50% acetic acid (4 ml) solutions as well as in gel form.…”

Section: Mainmentioning

confidence: 99%

Producing the appropriate model and drug for intratumoural ablation

et al. 2020

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Summary Local treatment is necessary for several cancer patients. There are situations where cancer tissue induces locally severe symptoms. Therefore, additional local disease control is necessary. There are two major issues for efficient local treatment: the method of application and the penetration of the drug formulation. We need efficient tools to guide the drug formulation to the target point, and an effective drug formulation that is diffused within the tumour microenvironment with a sustained-release effect.

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Tissue Chemoablation

Cited by 12 publications

References 128 publications

Role of Chemokines in the Biology of Cholangiocarcinoma

Role of Chemokines in the Biology of Cholangiocarcinoma

Effects of direct injection of dehydrated ethanol on PC3 human prostate cancer cells in nude mice: Preliminary study

Producing the appropriate model and drug for intratumoural ablation

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