Tissue composition effect on dose distribution in neutron brachytherapy/neutron capture therapy

Khosroabadi, Mohsen; Farhood, Bagher; Ghorbani, Mahdi; Hamzian, Nima; Moghaddam, Homa Rezaei; Davenport, David

doi:10.1016/j.rpor.2015.05.001

Cited by 10 publications

(6 citation statements)

References 15 publications

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“…Following the interaction, high linear energy transfer (LET) products (alpha particles and recoiling 7 Li nuclei) are produced. [2][3][4][5][6][7] The deposited energies of these heavy particles are shown below 8 : These products deposit their energies in a range of 5-9 m. This range corresponds to the diameter of a cell, 9 and the harmful effects of these compounds with high LET are limited to boron comprising cells. Therefore, BNCT presents a method to selectively eradicate malignant cells and spare adjacent normal cells.…”

Section: Bnctmentioning

confidence: 99%

Physical, dosimetric and clinical aspects and delivery systems in neutron capture therapy

Farhood

Samadian

Ghorbani

et al. 2018

Reports of Practical Oncology & Radiotherapy

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Neutron capture therapy (NCT) is a targeted radiotherapy for cancer treatment. In this method, neutrons with a spectra/specific energy (depending on the type of agent used for NCT) are captured with an agent that has a high cross-section with these neutrons. There are some agents that have been proposed in NCT including B,Gd and S. Among these agents, onlyB is used in clinical trials. Application of Gd is limited to in-vivo and in-vitro research. In addition,S has been applied in the field of Monte Carlo simulation. In BNCT, the only two delivery agents which are presently applied in clinical trials are BPA and BSH, but other delivery systems are being developed for more effective treatment in NCT. Neutron sources used in NCT are fission reactors, accelerators, and Cf. Among these, fission reactors have the most application in NCT. So far, BNCT has been applied to treat various cancers including glioblastoma multiforme, malignant glioma, malignant meningioma, liver, head and neck, lung, colon, melanoma, thyroid, hepatic, gastrointestinal cancer, and extra-mammary Paget's disease. This paper aims to review physical, dosimetric and clinical aspects as well as delivery systems in NCT for various agents.

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Section: Bnctmentioning

confidence: 99%

Physical, dosimetric and clinical aspects and delivery systems in neutron capture therapy

Farhood

Samadian

Ghorbani

et al. 2018

Reports of Practical Oncology & Radiotherapy

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“…To obtain the Monte Carlo dosimetric output per photon, in units of MeV/photon, the MC results were divided by the mass of the corresponding voxels. 38 The track length estimation of energy deposition (F6) was employed to get the mass of the scoring cells.…”

Section: Monte Carlo Simulationmentioning

confidence: 99%

Effects of Siemens TT-D carbon fiber table top on beam attenuation, and build up region of 6 MV photon beam

Sheykhoo

Abdollahi

Yazdi

et al. 2017

Reports of Practical Oncology & Radiotherapy

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“…Radiation therapy including external radiotherapy and brachytherapy is an indispensable part of cancer treatment modalities, with more than half of all cancer patients who have undergone radiotherapy. This includes millions of people around the world [1]. So, improvement in radiotherapy efficiency associated with reduction of early and late side effects of exposure to radiation are most important aims in this way.…”

Section: Introductionmentioning

confidence: 99%

Radiation-induced Non-targeted Effect and Carcinogenesis; Implications in Clinical Radiotherapy

et al. 2018

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Bystander or non-targeted effect is known to be an interesting phenomenon in radiobiology. The genetic consequences of bystander effect on non-irradiated cells have shown that this phenomenon can be considered as one of the most important factors involved in secondary cancer after exposure to ionizing radiation. Every year, millions of people around the world undergo radiotherapy in order to cure different types of cancers. The most crucial aim of radiotherapy is to improve treatment efficiency by reducing early and late effects of exposure to clinical doses of radiation. Secondary cancer induction resulted from exposure to high doses of radiation during treatment can reduce the effectiveness of this modality for cancer treatment. The perception of carcinogenesis risk of bystander effects and factors involved in this phenomenon might help reduce secondary cancer incidence years after radiotherapy. Different modalities such as radiation LET, dose and dose rate, fractionation, types of tissue, gender of patients, etc. may be involved in carcinogenesis risk of bystander effects. Therefore, selecting an appropriate treatment modality may improve cost-effectiveness of radiation therapy as well as the quality of life in survived patients. In this review, we first focus on the carcinogenesis evidence of non-targeted effects in radiotherapy and then review physical and biological factors that may influence the risk of secondary cancer induced by this phenomenon.

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Tissue composition effect on dose distribution in neutron brachytherapy/neutron capture therapy

Abstract: Background: Neutron brachytherapy and neutron capture therapy are two common radiothe-

Cited by 10 publications

References 15 publications

Physical, dosimetric and clinical aspects and delivery systems in neutron capture therapy

Physical, dosimetric and clinical aspects and delivery systems in neutron capture therapy

Effects of Siemens TT-D carbon fiber table top on beam attenuation, and build up region of 6 MV photon beam

Radiation-induced Non-targeted Effect and Carcinogenesis; Implications in Clinical Radiotherapy

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