Tissue concentration, mRNA expression and stimulation of IGF-I in luteal tissue during the oestrous cycle and pregnancy of cows

Einspanier, Ralf; Miyamoto, Atsushi; Schams, D.; Müller, Mathias; Brem, Gottfried

doi:10.1530/jrf.0.0900439

Cited by 78 publications

(43 citation statements)

References 6 publications

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“…These trends were confirmed by RPA (ribunoclease protection assay) and localization of the proteins [56]. The bovine corpus luteum in general has been shown to express IGF-1 mRNA [57][58][59][60][61]. In most cases CL were collected from day 5 onwards.…”

Section: Igf In Bovine Corpus Luteummentioning

confidence: 69%

Angiogenic Factors (VEGF, FGF and IGF) in the Bovine Corpus Luteum.

Schams

Berisha

2002

Journal of Reproduction and Development

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Abstract. Angiogenesis, the development of the new capillaries by endothelial cell proliferation and outgrowth from pre-existing vessels, is one of the prominent features of early corpus luteum (CL). The process of angiogenesis is an important component of normal development and function of CL. Of the numerous promoters of angiogenesis and maintenance of new established capillaries that have been identified, the most important factors appear to be vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (FGF). The biological effects of VEGF and FGF factor families are mediated by signaling through specific tyrosine kinase receptors. The VEGF, FGF and IGF family members in bovine CL are discussed with the literature available for large domestic animals. The highest expression for VEGF, VEGFR-2, FGF-2, FGFR, IGF-1, IGF-2 and IGFR1 were found during the early luteal phase (Ld 1-4) followed by a significant decrease afterwards. The VEGF and IGF-1 protein was localized predominantly in luteal cells. FGF-1 mRNA expression peaked (P<0.05) during mid-luteal stage and FGF-1 protein was localized in cytoplasm of luteal cells, but endothelial cells are always negative. FGF-2 protein during angiogenesis (d 1-5) was found in cytoplasm of endothelial cells and changed thereafter exclusively to the cytoplasm of luteal cells. In contrast, the IGF-2 protein is exclusively localized in pericytes and few endothelial cells. The results obtained (mainly in ruminant) suggest an important role of these growth factors for angiogenesis and furthermore for maintenance and function of the bovine corpus luteum.

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Section: Igf In Bovine Corpus Luteummentioning

confidence: 69%

Angiogenic Factors (VEGF, FGF and IGF) in the Bovine Corpus Luteum.

Schams

Berisha

2002

Journal of Reproduction and Development

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“…Indeed, GH increases ovarian levels of IGF-I in vitro in rats [26] and rabbits [27]. Moreover, in vitro studies have shown that IGF-I stimulates the secretion of P and OT from the CL of ewes [28] and cows [29][30][31]. We immunocytochemically examined the possibility that GH may directly increase IGF-I production in luteal cells surrounding the microcapillary mem- brane in the cyclic ewes used in experiment 1.…”

Section: Discussionmentioning

confidence: 99%

Comparative Activities of Growth Hormone and Luteinizing Hormone in the Direct Stimulation of Local Release of Progesterone from Microdialyzed Ovine Corpora Lutea In Vivo.

Miyamoto

Takemoto

Acosta

et al. 1998

Journal of Reproduction and Development

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“…IGF-I promotes FSH and LH supported steriodogenesis on follicular cells, LH receptor induction, and inhibin synthesis [2,36]. It is also a potent in vitro stimulator of the release of progesterone in cultures of bovine luteal cells or intact tissues [30,51,76]. In the steroidogenic pathway IGFs have been shown to stimulate the aromatase system [3,24].…”

Section: Endocrine Effects Of Igf-i On Reproductive Functionmentioning

confidence: 99%

Insulin-Like Growth Factor-I as a Possible Hormonal Mediator of Nutritional Regulation of Reproduction in Cattle

Zulu

Nakao

Sawamukai

2002

The Journal of Veterinary Medical Science

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ABSTRACT. The current review aims to establish insulin-like growth factor-1 (IGF-I) as the factor that signals nutritional status to the reproductive axis, and show that assessment of IGF-I in blood early postpartum during the negative energy balance (NEB) period could be used to predict both nutritional and reproductive status in dairy cattle. The review also explores the effect of nutritional status on circulating IGF-I concentrations and the endocrine role of IGF-I on the reproductive axis. IGF-I plays an important role in gonadotropininduced folliculogenesis, ovarian steroidogenesis and corpus luteum (CL) function. It also modulates pituitary and hypothalamus function. IGF-I clearly has an endocrine role on the reproductive axis. Severe under nutrition significantly reduces plasma IGF-I concentrations. During the critical period of NEB in high yielding dairy cattle early postpartum, IGF-I concentrations are low in blood and its levels are positively correlated to energy status and reproductive function during this period. Changes in circulating IGF-I immediately postpartum may help predict both nutritional and reproductive status in dairy cattle. IGF-I is therefore one of the long sought factors that signal nutritional status to the reproductive axis.

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Tissue concentration, mRNA expression and stimulation of IGF-I in luteal tissue during the oestrous cycle and pregnancy of cows

Cited by 78 publications

References 6 publications

Angiogenic Factors (VEGF, FGF and IGF) in the Bovine Corpus Luteum.

Angiogenic Factors (VEGF, FGF and IGF) in the Bovine Corpus Luteum.

Comparative Activities of Growth Hormone and Luteinizing Hormone in the Direct Stimulation of Local Release of Progesterone from Microdialyzed Ovine Corpora Lutea In Vivo.

Insulin-Like Growth Factor-I as a Possible Hormonal Mediator of Nutritional Regulation of Reproduction in Cattle

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