Tissue concentrations of organochlorine compounds in common seals from the coast of Northern Ireland

Mitchell, Samuel H; Kennedy, S.

doi:10.1016/0048-9697(92)90040-y

Cited by 31 publications

(13 citation statements)

References 18 publications

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“…Comparisons between blubber CHC data in this study and other recent work indicated that the PCB concentrations in seals from Hokkaido appeared to be comparable to those in seals from North America [23,24] and the Arctic [25] but one to two orders of magnitude lower than those of European seals [26][27][28]. Dichlorodiphenyltrichloroethylene and other pesticide residue levels in this study were similar to those of the European [26,[29][30][31], North American [23,24,32], and Arctic seals [25].…”

Section: Resultssupporting

confidence: 76%

Negative correlation between plasma thyroid hormone levels and chlorinated hydrocarbon levels accumulated in seals from the coast of Hokkaido, Japan

Chiba

Sakakibara

Gotö

et al. 2001

Enviro Toxic and Chemistry

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Chlorinated hydrocarbon (CHC) levels in the blubber of larga seals (Phoca largha) and ribbon seals (Phoca fasciata) collected from the coastal waters of Hokkaido, Japan, were determined in order to assess the hormonal effects of CHC exposure in free-ranging pinnipeds. Plasma thyroid hormone levels, including total thyroxine (T4), free thyroxine (free T4), total triiodothyronine (T3), and free triiodothyronine (free T3), were also measured. Higher concentrations of polychlorinated biphenyl congeners (PCBs), dichlorodiphenyltrichloroethane and its metabolites, and chlordane compounds were found in the range of 380 to 2,600 ng/g, 350 to 2,600 ng/g, and 120 to 760 ng/g on a wet-weight basis, respectively. Spearman rank correlation analyses showed that in larga seals, plasma total T3 and free T3 levels negatively correlated with levels of all the CHCs analyzed, although there was no such correlation between total or free T4 levels and CHC concentrations. In ribbon seals, total T3 levels significantly decreased with an increase of di-ortho PCB (PCB170 and 180) residues. These findings indicated that the plasma T3 deficiency could be associated with some CHC exposure in larga and ribbon seals and that the responses of plasma thyroid hormones may be useful biomarkers for CHC exposure in ribbon seals.

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Section: Resultssupporting

confidence: 76%

Negative correlation between plasma thyroid hormone levels and chlorinated hydrocarbon levels accumulated in seals from the coast of Hokkaido, Japan

Chiba

Sakakibara

Gotö

et al. 2001

Enviro Toxic and Chemistry

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“…Fish serve useful as genetic models for the evaluation of pollution in aquatic ecosystems (Mitchell and Kennedy, 1992;and Park et al, 1993). The erythrocyte micronucleus test has been used with different fish species to monitor aquatic pollutants displaying mutagenic features (De Flora et al, 1993).…”

Section: Introductionmentioning

confidence: 99%

Comparison between the micronucleus frequencies of kidney and gill erythrocytes in tilapia fish, following mitomycin C treatment

Palhares¹,

Grisólia²

2002

Genet. Mol. Biol.

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The frequencies of mitomycin C and cyclophosphamide-induced kidney and gill erythrocyte micronuclei were compared in Tilapia rendalli and Oreochromis niloticus. Cyclophosphamide (CP) and mitomycin C (MMC) were previously used to investigate fish sensitivity to micronuclei induction in kidney erythrocytes. Fish were treated with a single dose of cyclophosphamide (40 mg/kg) or mitomycin C (2 mg/kg). Peripheral blood samples and kidney blood samples were obtained, 1, 2, 3, 5, 7, and 15 days after the intra-abdominal injection of MMC. T. rendalli showed to be more sensitive than O. niloticus to micronuclei production. Both compounds were used at the maximum tolerated dose (MTD), and mitomycin C proved to be more toxic than cyclophosphamide. The frequency of micronucleated erythrocytes observed varied significantly among the treated individuals. The difference between the kidney and gill micronuclei frequencies was not significant. Higher levels of micronucleated erythrocytes were observed in Tilapia rendalli than in O. niloticus. T. rendalli produced erythrocytes with deformed nuclei, which O. niloticus did not.

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“…Previous works have demonstrated that in aquatic ecosystems, the best genetic model for pollution assessment is fish (Mitchell and Kennedy, 1992;Park et al,1993;Anifowoshe et al, 2018), however, most of the aquatic ecosystems are still used for waste disposal for all waste produced by man. The consequence of this will not only affect the aquatic animals but also the terrestrial animals.…”

Section: Discussionmentioning

confidence: 99%

Induction of Micronuclei, Base-pair Substitution Mutation and Excision-repair Deficient by Polluted Water from Asa River in Nigeria

Abass

Oladipo

Mutolib

et al. 2019

Annals of Science and Technology

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Asa river is a major river designated to supply millions of people of Ilorin, Kwara State, Nigeria potable water for drinking but its managements is of grave concern due to anthropogenic activities. Thus, evaluation of genotoxicity of this river was carried out by subjecting the water samples and fish therein to three bioassays (Micronucleus (MN) assay, Ames test and SOS-chromo test). Physicochemical parameters and heavy metals were analysed at three different stations (Aliara (SI), Unity (SII) and Tuyil (SIII)) of the river. In SII, most of the heavy metals analysed were above the acceptable limits compare to SI and SIII. The peripheral erythrocyte of the fishes (Oreochromis niloticus, Synodontis batensoda, Synodontis eupterus, Clarias gariepinus and Clarias angullaris) at SI and SII stations showed a significant (p<0.05) induction of MN and different nuclear abnormalities (NA). Water samples from the three stations subjected to Ames test (Salmonella typhimurium TA100) and SOS chromotests (Escherichia coli PQ37) at 25%, 50% and 100% concentrations showed statistically significant (p<0.05) induction of DNA damage at all concentrations in the two tester strains, thus indicating base-pair substitution mutation and excision-repairdeficient, respectively, by the water samples. Therefore, drinking of this water and/or consumption of fish from this river should be taken with caution to avoid a carcinogenic risk.

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Tissue concentrations of organochlorine compounds in common seals from the coast of Northern Ireland

Cited by 31 publications

References 18 publications

Negative correlation between plasma thyroid hormone levels and chlorinated hydrocarbon levels accumulated in seals from the coast of Hokkaido, Japan

Negative correlation between plasma thyroid hormone levels and chlorinated hydrocarbon levels accumulated in seals from the coast of Hokkaido, Japan

Comparison between the micronucleus frequencies of kidney and gill erythrocytes in tilapia fish, following mitomycin C treatment

Induction of Micronuclei, Base-pair Substitution Mutation and Excision-repair Deficient by Polluted Water from Asa River in Nigeria

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