Tissue Degeneration 7 Years After Breast Augmentation With Injected Polyacrylamide Hydrogel (PAAG)

Xu, Chuanjun; Cao, Mo; Bao, Bing; Li, Huizheng; Yin, Dongyun

doi:10.1007/s00266-011-9779-8

Cited by 10 publications

(3 citation statements)

References 6 publications

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“…Previous histopathological findings of PAAG capsules revealed fibrous connective tissue hyperplasia, degeneration of breast tissue, formation of fibrous tissue, and fiber contraction, leading to displaced papillae and mastodynia [12]. Another report revealed macrophages and giant cells surrounding the PAAG, suggesting a foreign body reaction, similar to our finding [13].…”

Section: Discussionsupporting

confidence: 88%

Complications of polyacrylamide hydrogel injection for breast augmentation: A case report and literature review

Park

2019

Arch Aesthetic Plast Surg

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Section: Discussionsupporting

confidence: 88%

Complications of polyacrylamide hydrogel injection for breast augmentation: A case report and literature review

Park

2019

Arch Aesthetic Plast Surg

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“…Third, the temporal pain could have been due to two causes. The first is the degeneration of the temporalis muscle after PAAG injection, which is supported by the previous observation of pectoral muscle degeneration induced by PAAG injected into the breasts [ 7 , 8 ]. Although we did not collect temporalis tissue for histological examination due to our concern that this might injure the facial nerves, the more severe pain in the left temple, where the muscles showed the most filler infiltration, and the pain induced by changes in facial expression may indicate muscle degeneration.…”

Section: Discussionsupporting

confidence: 70%

A Case of Special Complication following a Large Amount of Polyacrylamide Hydrogel Injected into the Epicranial Aponeurosis: Leukocytopenia

Lan

Shao

et al. 2015

Case Reports in Medicine

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Polyacrylamide hydrogel (PAAG) has been used as an injectable filler for soft tissue augmentation of different body parts, such as the face, breasts, and penis. However, this is the first report of leukocytopenia after injection of a large amount of PAAG in the epicranial aponeurosis. After receiving PAAG injection for craniofacial contouring, the female patient described herein experienced recurrent swelling, temporal pain (particularly with changes in ambient temperature and facial expression), and ultimately leukocytopenia due to widespread migration of the injected PAAG. We removed most of the PAAG from the affected tissues and the leukocytopenia disappeared 1 year after the operation. Based on this case, we hypothesize that injection of a large amount of PAAG into tissues that have ample blood supply, such as the epicranial aponeurosis, may induce leukocytopenia.

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“…Studies have shown that polyacrylamide is harmless to the body, but the acrylamide monomer released from polyacrylamide contains toxins [ 17 ]. The toxicity of acrylamide mainly includes neurotoxicity, reproductive toxicity, genetic toxicity, immunotoxicity, and potential carcinogenicity [ 18 , 19 , 20 ].…”

Section: Discussionmentioning

confidence: 99%

Breast Augmentation with Autologous Fat Grafting Immediately after Removal of Polyacrylamide Hydrogel and Fibrotic Capsule in 162 Patients

Gao

Zhai

et al. 2022

Breast Care

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Objective In this study we investigated the feasibility and efficacy of immediate breast augmentation with autologous fat grafting after removal of polyacrylamide hydrogel(PAAG) and fibrotic capsule. Methods A retrospective study was conducted on 162 female patients who underwent removal of breast filler polyacrylamide hydrogel(PAAG) and the fibrotic capsule which produced after injection of PAAG via areola Omega-shaped incision. Then autologous fat grafting was immediately performed evenly and radially around the areola via the same incision into different layers (subcutaneous,submammary tissue,pectoralis major intramuscular and inferior pectoralis major space) except the empty cavity.The cavity left by removal of PAAG and fibrous capsule was closed with negative pressure drainage tube and slight external pressure. Results All patients recovered well without severe complications. The average score of postoperative satisfaction with physical well-being:chest was 99.83 (total score:100) compared with the average satisfaction score of 71.69 (total score:100) preoperatively by means of BREAST-QTM evaluation(P<0.01).All patients were satisfied with their postoperative breast shape. Conclusions Removing as much as possible is critical for patients who underwent the PAAG injection.Our experience in immediate breast augmentation with autologous fat grafting after removal of PAAG and fibrotic capsule proved useful and effective to maintain the balance between removing the PAAG as much as possible and retaining soft tissue to reshape breasts.

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Tissue Degeneration 7 Years After Breast Augmentation With Injected Polyacrylamide Hydrogel (PAAG)

Cited by 10 publications

References 6 publications

Complications of polyacrylamide hydrogel injection for breast augmentation: A case report and literature review

Complications of polyacrylamide hydrogel injection for breast augmentation: A case report and literature review

A Case of Special Complication following a Large Amount of Polyacrylamide Hydrogel Injected into the Epicranial Aponeurosis: Leukocytopenia

Breast Augmentation with Autologous Fat Grafting Immediately after Removal of Polyacrylamide Hydrogel and Fibrotic Capsule in 162 Patients

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