Tissue deposition patterns after chronic inhalation exposures of rats and guinea pigs to aluminum chlorhydrate

Stone, Carly; McLaurin, Daniel A.; Steinhagen, William H.; Cavender, Finis L.; Haseman, J. K.

doi:10.1016/0041-008x(79)90278-3

Cited by 20 publications

(8 citation statements)

References 2 publications

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“…In addition, a study showed that exposure to HCB induced pulmonary inflammatory lesions with accumulations of alveolar macrophages and proliferation of the pulmonary vessel endothelium, which was Controled by perivascular infiltrate, composed of eosinophilic granulocytes and monocytes (Michielsen et al, 1997;Michielsen et al, 1999). In addition, an increase in lung weight was observed in rats and guinea pigs exposed by inhalation to 6.1 mg.Al/m3 (as aluminum hydrochloride) at a rate of 6h/day, 5d/week for 2 years (Stone et al, 1979). Also, this study confirm the research of Grassina et al, (2011), about the use of cannabis bong results in pulmonary intoxication and alveolar hemorrhage.…”

Section: Treatment Effects On the Histology Of Lung Tissuesupporting

confidence: 88%

Preventive Effects of Citrullus Colocynthis. L Plant Extract on Deltamethrin Pesticide Induced Pneumotoxicity in Wister Rats

Gasmi

Benaicha²,

Kebieche³

et al. 2021

J microb biotech food sci

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Pesticides are chemicals used to fight agricultural pests. Their use causes extensive damage to both humans and animals, resulting in diseases mainly affecting the respiratory and digestive systems. Through this study, we evaluated the pneumotoxicity caused by a deltamethrin (DM) insecticide at a dose of 0.64mg.kg-1.day-1. We also evaluated the preventive and curative effect of the medicinal plant "citrullus colocynthis. L" antagonist of this toxicity at a dose of 150mg.kg-1.day-1. We carried out the experimental application on Wister rats as an animal model of exhalation. Several experiments were carried out on the activity of enzymes and vital indicators. This study revealed a decrease in the concentration of the protein accompanied by a decrease in the means of development of the body [25±0.23]. Then, our study showed that DM has an oxidative effect, resulting in a decrease in the level of GSH [0.05 ±0.00] and the enzymatic activity of GPx [0.34±0.05]. In addition to an increase in the level of MDA [4.90±0.72] and the enzymatic activity of GST [0.84±0.11]. In addition, the histological study carried out on a fragment of lung of rats treated with this pesticide showed changes in the histological structure of the lungs resulting in vascular congestion, infiltration of inflammatory cells, thickening of the walls of blood vessels, as we do. Observed intra-alveolar hemorrhages and hyperplasia of the alveolar lining. On the other hand, we have confirmed the preventive effect of the citrullus colocynthis. L after treatment with this pesticide, which has an anti-oxidant activity, which can reduce the intensity of the oxidative stress resulting from deltamethrin and its effectiveness. In the treatment of lung, tissue effected by this pesticide and it is stored in its natural state.

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Section: Treatment Effects On the Histology Of Lung Tissuesupporting

confidence: 88%

Preventive Effects of Citrullus Colocynthis. L Plant Extract on Deltamethrin Pesticide Induced Pneumotoxicity in Wister Rats

Gasmi

Benaicha²,

Kebieche³

et al. 2021

J microb biotech food sci

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“…Inhalation and ingestion (via food and water) are the two main routes through which Al gets into the body (Alfrey, 1980;Teraoka, 1981;Jouhanneau et al, 1997). Following inhalation, Al compounds are deposited in the lungs (Christie et al, 1963;Stone et al, 1979;Thomson et al, 1986). The lungs continually receive Al mostly as particles of Al silicates and other poorly soluble compounds (Thomson et al, 1986).…”

Section: Absorption Distribution and Elimination Of Aluminiummentioning

confidence: 99%

Aluminium toxicosis: a review of toxic actions and effects

Igbokwe

Igwenagu

Igbokwe

2019

Interdisciplinary Toxicology

274

149

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Aluminium (Al) is frequently accessible to animal and human populations to the extent that intoxications may occur. Intake of Al is by inhalation of aerosols or particles, ingestion of food, water and medicaments, skin contact, vaccination, dialysis and infusions. Toxic actions of Al induce oxidative stress, immunologic alterations, genotoxicity, pro-inflammatory effect, peptide denaturation or transformation, enzymatic dysfunction, metabolic derangement, amyloidogenesis, membrane perturbation, iron dyshomeostasis, apoptosis, necrosis and dysplasia. The pathological conditions associated with Al toxicosis are desquamative interstitial pneumonia, pulmonary alveolar proteinosis, granulomas, granulomatosis and fibrosis, toxic myocarditis, thrombosis and ischemic stroke, granulomatous enteritis, Crohn’s disease, inflammatory bowel diseases, anemia, Alzheimer’s disease, dementia, sclerosis, autism, macrophagic myofasciitis, osteomalacia, oligospermia and infertility, hepatorenal disease, breast cancer and cyst, pancreatitis, pancreatic necrosis and diabetes mellitus. The review provides a broad overview of Al toxicosis as a background for sustained investigations of the toxicology of Al compounds of public health importance.

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“…Aluminium levels have been found to increase with ageing in a number of tissues and organs (bone, muscle, lung, liver, and kidney) of experimental animals (Golub et al, 1996a, Kukhtina, 1972, Stone et al, 1979, Massie et al, 1988, Greger & Radzanowski, 1995. The limited data available suggest that brain and blood aluminium concentrations also increase with age.…”

Section: Animal Studiesmentioning

confidence: 99%

Safety of aluminium from dietary intake ‐ Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Food Contact Materials (AFC)

2008

EFS2

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Following a request from the Commission, the Panel on Food Additives, Flavourings, Processing Aids and Food Contact Materials (AFC) was asked to provide a scientific opinion on the safety of aluminium from all sources of dietary intake. In the event the estimated exposure for a particular sub-group(s) is found to exceed the Provisional Tolerable Weekly Intake, a detailed breakdown by exposure source should be provided. Aluminium occurs naturally in the environment and is also released due to anthropogenic activities such as mining and industrial uses, in the production of aluminium metal and other aluminium compounds. A variety of aluminium compounds are produced and used for different purposes, such as in water treatment, papermaking, fire retardant, fillers, food additives, colours and pharmaceuticals. Aluminium metal, mainly in the form of alloys with other metals, has many uses including in consumer appliances, food packaging and cookware. The major route of exposure to aluminium for the general population is through food. Aluminium in drinking water represents another, minor, source of exposure. Additional exposures may arise from the use of aluminium compounds in pharmaceuticals and consumer products. Most unprocessed foods typically contain less than 5 mg aluminium/kg. Higher concentrations (mean levels 5 to 10 mg/kg) were often found in breads, cakes and pastries (with biscuits having the highest levels), some vegetables (with mushrooms, spinach, radish, swiss card, 1 For citation purposes: Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Food Contact Materials on a request from European Commission on Safety of aluminium from dietary intake.

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Tissue deposition patterns after chronic inhalation exposures of rats and guinea pigs to aluminum chlorhydrate

Cited by 20 publications

References 2 publications

Preventive Effects of Citrullus Colocynthis. L Plant Extract on Deltamethrin Pesticide Induced Pneumotoxicity in Wister Rats

Preventive Effects of Citrullus Colocynthis. L Plant Extract on Deltamethrin Pesticide Induced Pneumotoxicity in Wister Rats

Aluminium toxicosis: a review of toxic actions and effects

Safety of aluminium from dietary intake ‐ Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Food Contact Materials (AFC)

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