Tissue Differential Microarray Analysis of Dexamethasone Induction Reveals Potential Mechanisms of Steroid Glaucoma

Lo, Wayne R.; Rowlette, Laura Leigh S; Caballero, Montserrat; Yang, Ping; Hernandez, M. Rosario; Borrás, Teresa

doi:10.1167/iovs.02-0444

Cited by 123 publications

(119 citation statements)

References 49 publications

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“…al., Invest Ophthalmol Vis Sci 46: e-abstract #1349, 2005. (Lo et al 2003;Zhao et al 2004;Vittal et al 2005;Keller et al 2007b) In addition, TGFβ has been shown to produce a shift in the proportion of TM versican mRNA splice variants increasing domains containing additional CS GAG attachment sites (Fig. 2).…”

Section: Alternative Splicing Of Ecm Componentsmentioning

confidence: 98%

“…This includes a number of SLRPs, CSPGs, HSPGs, and other types of PGs (Table 1). (Murphy et al 1987;Tanihara et al 1995;Wirtz et al 1997;Knepper, P et al 1998;Friedman et al 2000;Friedman et al 2002;Ishibashi et al 2002;Knepper, P et al 2002;Borras 2003;Lo et al 2003;Filla et al 2004;Vittitow and Borras 2004;Zhao et al 2004;Chen et al 2005;Vittal et al 2005;Keller et al 2007b) Some specific core proteins have been localized to regions of the TM by immunohistochemistry using light or transmission electron microscopy. Perlecan was localized to the basement membranes of the TM beams and SC inner wall cells.…”

Section: Proteoglycansmentioning

confidence: 99%

“…(Clark et al 1995b;Clark et al 2005) Much of this effect may be due to dramatic cytoskeleton changes, i.e., the formation of cross-linked actin networks (CLANs) (Clark et al 1994;Clark et al 1995a), or to a number of other TM cell responses, e.g., increased expression of myocilin. (Polansky et al 1997;Stone et al 1997;Polansky and Nguyen 1998;Polansky et al 2000;Lo et al 2003) Myocilin has been shown to affect outflow facility, although the exact mechanism appears to be complex. (Borras et al 2002;Goldwich et al 2003;Zillig et al 2005; Myocilin also binds several ECM components, including the hep II domain of fibronectin, (Filla et al 2002) and is found in the JCT and SC region.…”

Section: Tgfβmentioning

confidence: 99%

“…Several ECM genes' expression was changed in response to dexamethasone treatment, including a reduction in versican and an increase in fibronectin levels. (Steely et al 1992;Liu et al 2003;Lo et al 2003) Glucocorticoids also increase ECM deposition in the TM, producing a fingerprint-like arrangement somewhat resembling basement membrane material. (Johnson et al 1997) This pattern differs from the SD plaques seen with glaucoma (see later).…”

Section: Tgfβmentioning

confidence: 99%

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Extracellular matrix in the trabecular meshwork

Acott

Kelley

2008

Experimental Eye Research

425

443

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The extracellular matrix (ECM) of the trabecular meshwork (TM) is thought to be important in regulating intraocular pressure (IOP) in both normal and glaucomatous eyes. IOP is regulated primarily by a fluid resistance to aqueous humor outflow. However, neither the exact site nor the identity of the normal resistance to aqueous humor outflow has been established. Whether the site and nature of the increased outflow resistance, which is associated with open-angle glaucoma, is the same or different from the normal resistance is also unclear.The ECMs of the TM beams, juxtacanalicular region (JCT) and Schlemm's canal (SC) inner wall are comprised of fibrillar and non-fibrillar collagens, elastin-containing microfibrils, matricellular and structural organizing proteins, glycosaminoglycans (GAGs) and proteoglycans. Both basement membranes and stromal ECM are present in the TM beams and JCT region. Cell adhesion proteins, cell surface ECM receptors and associated binding proteins are also present in the beams, JCT and SC inner wall region.The outflow pathway ECM is relatively dynamic, undergoing constant turnover and remodeling. Regulated changes in enzymes responsible for ECM degradation and biosynthetic replacement are observed. IOP homeostasis, triggered by pressure changes or mechanical stretching of the TM, appears to involve ECM turnover. Several cytokines, growth factors and drugs, which affect the outflow resistance, change ECM component expression, mRNA alternative splicing, cellular cytoskeletal organization or all of these. Changes in ECM associated with open-angle glaucoma have been identified.

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Section: Alternative Splicing Of Ecm Componentsmentioning

confidence: 98%

Section: Proteoglycansmentioning

confidence: 99%

Section: Tgfβmentioning

confidence: 99%

Section: Tgfβmentioning

confidence: 99%

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Extracellular matrix in the trabecular meshwork

Acott

Kelley

2008

Experimental Eye Research

425

443

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“…A metabolic hypothesis has its clinical fundament in the clinically attested relationship between steroid hormones and drugs and glaucoma in a segment of the population [28]. Finally, and increasing in acceptance, is the genetic hypothesis [29,30], used in the search for the genes responsible for the disease and which, naturally, encompasses both hypertensive and normotensive cases, and defines glaucoma as a neuro-degenerative disease. We will begin with the last.…”

Section: Current Paradigmsmentioning

confidence: 99%

Glaucoma as a Tax on Hominid Evolution. Constraints of the Experimental Animal Models of Glaucoma

Carreras¹

2016

J Clin Exp Ophthalmol

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Glaucoma continues to be a mysterious disease. High intraocular pressure (IOP), once the landmark of the disease, has been relegated to the humble role of risk factor, despite the fact that lowering IOP continues to be the only partially successful treatment. Even with an IOP successfully controlled to statistical standards, many patients still mysteriously continue to progressively lose neural tissue. A novel pathogenetical mechanism has recently been put forward as the main agent of the disease. In this new light, some structural details of the human eye, the result of the peculiar evolutionary development, take on an unexpected role in the presentation of the disease. As results of cladistics analysis, the human eye appears as particularly prone to suffering glaucoma as a consequence of the evolutionary path taken. That makes glaucoma essentially a human (and related hominid) scourge. Exclusive features of the human eye compared to other vertebrates involve both the anterior and posterior segment. Those features that facilitate glaucoma in humans are absent in many of the purported animal models for the disease, and this inadequacy further convolutes the mystery of glaucoma. This suggests the division of the animal models into those that mimic the whole disease and those that only reproduce a pertinent histological feature. Unfortunately most animal models are based on high intraocular pressure which excludes most cases of low or moderate pressure. For any animal model, it is important the researcher accurately establishes the constraints of the model in order to avoid jumping to conclusions.

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Ocular-Hypertensive and Anti-inflammatory Response to Rimexolone Therapy in Children

Fan¹

2003

Arch Ophthalmol

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Objective: To compare the ocular-hypertensive and antiinflammatory response to rimexolone (116-hydroxy-16␣fluoro-6␣methylpresdnisolone) and fluorometholone (21-deoxy-9␣fluoro-6␣methylprednisolone) therapy in children's eyes.Methods: With parental consent, children who underwent surgical procedures for bilateral symmetric strabismus from January 18, 2000, through November 16, 2001, were recruited. One eye was randomized to receive topical 1% rimexolone while the contralateral eye received topical 0.1% fluorometholone, 4 times daily for 4 weeks. Main Outcome Measures: Intraocular pressures and anti-inflammatory responses were the main outcome measures and were serially measured postoperatively for 8 weeks. Results: Fifty-four children, aged from 4 to 8 years (mean [SD] age, 5.33 [1.26] years), participated in the (REPRINTED) ARCH OPHTHALMOL / VOL 121, DEC 2003 WWW.ARCHOPHTHALMOL.COM 1716

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Tissue Differential Microarray Analysis of Dexamethasone Induction Reveals Potential Mechanisms of Steroid Glaucoma

Cited by 123 publications

References 49 publications

Extracellular matrix in the trabecular meshwork

Extracellular matrix in the trabecular meshwork

Glaucoma as a Tax on Hominid Evolution. Constraints of the Experimental Animal Models of Glaucoma

Ocular-Hypertensive and Anti-inflammatory Response to Rimexolone Therapy in Children

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