Tissue distribution of lead in the neonatal rat exposed to multiple doses of lead acetate

Miller, Gregory D.; Massaro, Thomas F.; Granlund, Rodger W.; Massaro, Edward J.

doi:10.1080/15287398309530326

Cited by 14 publications

(3 citation statements)

References 17 publications

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“…The kidney accumulates the highest concentrations of lead present in soft tissues (Mahaffey 1981;Miller et al 1983;Ashraf and Fosmire 1985), a finding also confirmed by the present study. The kidney had a higher lead concentration (approximately tenfold) and total content (approximately twofold) than the liver (Jamieson et al, in press).…”

Section: Discussionsupporting

confidence: 92%

Dietary zinc attenuates renal lead deposition but metallothionein is not directly involved

et al. 2007

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Chronic lead exposure irreversibly damages the kidneys and may be associated with hypertension and renal insufficiency at sub-clinically toxic levels. Zinc supplementation reduces lead absorption and tissue retention in rodent models but the mechanisms are unknown. Metallothionein (MT) may function in lead detoxification. Our objective was to investigate the effects of marginal zinc (MZ) and supplemental zinc (SZ) intakes on renal lead and zinc accumulation, renal MT immunolocalization and levels. Weanling Sprague Dawley rats were assigned to MZ (8 mg Zn/kg diet), zinc-adequate control (CT; 30 mg Zn/kg), zinc-adequate diet-restricted (DR; 30 mg Zn/kg) or SZ (300 mg Zn/kg) groups, with and without lead acetate-containing drinking water (200 mg Pb/L) for 3 weeks. Kidneys were analyzed for lead and zinc by inductively coupled plasma spectroscopy and MT by immunolocalization and Western blotting. MZ had higher renal lead and lower renal zinc concentrations than CT. SZ was more protective than CT against renal lead accumulation. Renal MT levels reflected dietary intake (SZ > or = DR > or = CT > or = MZ) but lead had no effect on MT staining intensity, distribution, or relative protein amounts. In summary, while SZ lowered renal lead concentration, MT did not appear to function in renal lead accumulation. Future studies should explore alternate mechanisms of renal lead detoxification.

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Section: Discussionsupporting

confidence: 92%

Dietary zinc attenuates renal lead deposition but metallothionein is not directly involved

et al. 2007

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“…A reduction in body weight with a lead dose of 250 mg/L has been observed (Grant et al, 1980), whereas a lead dose of 500 mg/L did not alter body weight (Hayashi, 1983). Similar to other studies of day 7}21 PN pups (Hejtmancik et al, 1982;Miller et al, 1983), we found no alterations. Despite the absence of alterations in the liver weight of neonates, it has been hypothesized that the adverse e!ects of lead are manifested throughout development.…”

Section: Discussionsupporting

confidence: 86%

Gestational and Lactational Lead Intoxication Produces Alterations in the Hepatic System of Rat Pups

Corpas

Benito

Marquina

et al. 2002

Ecotoxicology and Environmental Safety

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“…The distribution of Pb found in adult rats in this study (i.e., femur> kidney> liver> brain Pb) corresponds identically to the pattern which has been reported in rodents by several other investigators under unrestricted feeding conditions (e. g., Rader et al 198 I, 1983 ;Mykkanen et al 1982;Miller et al 1983). In fact, when tissue Pb ratios from this study are compared to those reported by Mykkanen et al (1982) Mykkanen et al).…”

Section: Discussionsupporting

confidence: 83%

Alterations in tissue Pb distribution and hematopoietic indices during advanced age

Cory‐Slechta

1990

Arch Toxicol

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The inevitable degenerative processes accompanying advanced age suggest that senescent organisms might exhibit differences in toxicokinetics or an altered manifestation of toxic effects. This hypothesis was tested in the present experiment which compared tissue distribution and hematopoietic indices in groups of adult (8 months) and old male Fischer-344 rats (16 months) exposed to concentrations of 0, 250 or 500 ppm lead (Pb) acetate in drinking water for 7 months. A group of young (weanling) rats was included as a partial comparison. Blood lead (PbB), zinc protoporphyrin (ZPP) and urinary delta-aminolevulinic acid levels were determined after both 3 and 7 months of exposure. Organ weights, tissue Pb concentrations and urinary excretion of Pb, calcium, copper, and zinc were examined after 7 months of exposure. Tissue Pb distribution was markedly altered in old rats: bone and kidney Pb were reduced; liver Pb was substantially increased, even though PbB levels in adult and old rats were comparable at both measurement intervals, as was urinary Pb excretion at 7 months. Pb-induced elevation of ZPPs exhibited differential changes between 3 and 7 months: values in adults declined while levels in old rats increased or remained unchanged. These findings show that the responses of adult rats to Pb do not predict those of older rats and indicate the need for further characterization and elaboration of mechanisms of toxic effects with advanced age.

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Tissue distribution of lead in the neonatal rat exposed to multiple doses of lead acetate

Cited by 14 publications

References 17 publications

Dietary zinc attenuates renal lead deposition but metallothionein is not directly involved

Dietary zinc attenuates renal lead deposition but metallothionein is not directly involved

Gestational and Lactational Lead Intoxication Produces Alterations in the Hepatic System of Rat Pups

Alterations in tissue Pb distribution and hematopoietic indices during advanced age

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