2015
DOI: 10.3923/ijp.2015.681.688
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Tissue Distribution of Prednisone/Prednisolone is Affected by TCM Danmo Capsule in Rats

Abstract: A B S T R A C T Danmo Capsule (DMC) is a patent Chinese botanic drug, widely used in combinational therapy with prednisone in China to treat renal diseases. The combined therapy regimen can reduce the dosage of glucocorticoids and relieve symptoms of glucocorticoid related adverse drug effects. Previous study from our laboratory showed that co-administration of the DMC significantly increased the plasma C max and AUC of glucocorticoid in rats. However, the effect of DMC on prednisone/prednisolone tissue distri… Show more

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