Tissue distribution of rat flavanol metabolites at different doses

Margalef, María; Pons, Zara; Bravo, Francisca Isabel; Muguerza, Begoña

doi:10.1016/j.jnutbio.2015.04.006

Cited by 46 publications

(48 citation statements)

References 33 publications

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“…of a flavanol-rich cocoa beverage [51]. Furthermore, it must be taken into account that macrophages do not differentiate in the circulation and that data from animal models reported a tissue and/or dose-dependent accumulation [52, 53]. Therefore, our in vitro results suggest an interesting hypothesis for in vivo study design.…”

Section: Discussionmentioning

confidence: 98%

Effect of Cocoa Polyphenolic Extract on Macrophage Polarization from Proinflammatory M1 to Anti‐Inflammatory M2 State

Dugo

Belluomo

Fanali

et al. 2017

Oxidative Medicine and Cellular Longevity

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Polyphenols-rich cocoa has many beneficial effects on human health, such as anti-inflammatory effects. Macrophages function as control switches of the immune system, maintaining the balance between pro- and anti-inflammatory activities. We investigated the hypothesis that cocoa polyphenol extract may affect macrophage proinflammatory phenotype M1 by favoring an alternative M2 anti-inflammatory state on macrophages deriving from THP-1 cells. Chemical composition, total phenolic content, and antioxidant capacity of cocoa polyphenols extracted from roasted cocoa beans were determined. THP-1 cells were activated with both lipopolysaccharides and interferon-γ for M1 or with IL-4 for M2 switch, and specific cytokines were quantified. Cellular metabolism, through mitochondrial oxygen consumption, and ATP levels were evaluated. Here, we will show that cocoa polyphenolic extract attenuated in vitro inflammation decreasing M1 macrophage response as demonstrated by a significantly lowered secretion of proinflammatory cytokines. Moreover, treatment of M1 macrophages with cocoa polyphenols influences macrophage metabolism by promoting oxidative pathways, thus leading to a significant increase in O2 consumption by mitochondrial complexes as well as a higher production of ATP through oxidative phosphorylation. In conclusion, cocoa polyphenolic extract suppresses inflammation mediated by M1 phenotype and influences macrophage metabolism by promoting oxidative pathways and M2 polarization of active macrophages.

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Section: Discussionmentioning

confidence: 98%

Effect of Cocoa Polyphenolic Extract on Macrophage Polarization from Proinflammatory M1 to Anti‐Inflammatory M2 State

Dugo

Belluomo

Fanali

et al. 2017

Oxidative Medicine and Cellular Longevity

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“…Duration of the study should be extended to increase blood and urine sampling and a ten fold higher GSE dosage (350 mg/kg) should be tested to reach improvement of statistical significance. Owing to its tremendous safety, GSE is increasingly used at high dosage (more than 500 mg/kg) according to our own data (Charradi et al, 2011[11], 2014[8], 2012[10], 2013[9]) or to current literature (Li et al, 2015[27]; Mansouri et al, 2011[28]; Margalof et al, 2015[29]).…”

Section: Discussionmentioning

confidence: 99%

Grape seed powder improves renal failure of chronic kidney disease patients

Turki

Charradi

Boukhalfa³

et al. 2016

EXCLI Journal; 15:Doc424; ISSN 1611-2156

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“…3-Hydroxybenzoic, benzoic and homovanillic acids were detected (at 0.43–1.06 nmol/g, 2.53–15.63 nmol/g and 1.84–2.39 nmol/g, respectively) in extracts of freeze-dried brain tissues of male Wistar rats orally fed with the grape seed proanthocyanidin extract (125, 250, 375, 1000 mg extract/kg b.w.). The levels of phenolic acids were dependent on the dose of the extract [119]. Benzoic acid was the main phenolic acid in brains of Sprague–Dawley rats that consumed wild blueberry for four and eight weeks.…”

Section: Penetration Of Brain By Phenolic Acidsmentioning

confidence: 99%

The Neuroprotective Effects of Phenolic Acids: Molecular Mechanism of Action

2017

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The neuroprotective role of phenolic acids from food has previously been reported by many authors. In this review, the role of phenolic acids in ameliorating depression, ischemia/reperfusion injury, neuroinflammation, apoptosis, glutamate-induced toxicity, epilepsy, imbalance after traumatic brain injury, hyperinsulinemia-induced memory impairment, hearing and vision disturbances, Parkinson’s disease, Huntington’s disease, anti-amyotrophic lateral sclerosis, Chagas disease and other less distributed diseases is discussed. This review covers the in vitro, ex vivo and in vivo studies concerning the prevention and treatment of neurological disorders (on the biochemical and gene expression levels) by phenolic acids.

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Tissue distribution of rat flavanol metabolites at different doses

Cited by 46 publications

References 33 publications

Effect of Cocoa Polyphenolic Extract on Macrophage Polarization from Proinflammatory M1 to Anti‐Inflammatory M2 State

Effect of Cocoa Polyphenolic Extract on Macrophage Polarization from Proinflammatory M1 to Anti‐Inflammatory M2 State

Grape seed powder improves renal failure of chronic kidney disease patients

The Neuroprotective Effects of Phenolic Acids: Molecular Mechanism of Action

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