Tissue Doppler Imaging Assessment of Left Ventricular Function in Diabetic Patients with Hepatitis C Virus (HCV)

Abstract

Background & Purpose: Hepatitis C virus (HCV) is the motive of many distinctive kinds of heart illnesses globally. Up till now, few cardiologists are aware of (HCV) as an etiology of heart sickness and its treatment. It has been nicely documented that the presence of diabetes mellitus (DM) changed into carefully connected to cardiovascular disorder. The aim of this work was to evaluate the left ventricular function in diabetic patient with hepatitis C (HCV) using tissue Doppler imaging "TDI". Study design: Comparative study. Setting: Menofia hospitals, Police Academic Hospital and Kafr El-Sheikh hospital from October 2016 to November 2018. Subjects: We included 50 adult HCV patients, allocated into 2 groups with BMI, age and sex matching. Group A: 25 patients below 50 years old who were diabetic (DM), and infected with HCV. Group B: 25 patients below 50 years old with HCV without Dm. Methods: All patients were subjected to Echocardiographic analysis, Doppler tissue imaging, ECG, blood sugar investigations and PCR for HCV. Results: In the studied population, we found that, comparative study between the 2 groups revealed; significant increase in LA mass index, in DM & HCV group (p = 0.035). Non-significant difference as regards all the remaining Echocardiographic variables (p > 0.05). Regarding correlations among DM & HCV cases; Mitral E had a highly significant positive correlation with HCV-PCR (p < 0.01). E/E' ratio and isovolumic relaxation time had a significant positive correlation with HCV-PCR (p < 0.05 respectively). It also shows that; septal mitral E' had a highly significant negative correlation with HCV-PCR (p = 0.004). And also shows that; the remaining Tissue Doppler Echocardiographic parameters, had non-significant correlation with HCV-PCR (p > 0.05). Conclusion: To conclude, our data suggests that, HCV infection had a significant impact on Lt ventricular diastolic function without any other predisposing factors probably due chronic inflammatory reaction and mild fibrosis of the heart muscle, previous studies did not follow strict inclusion and exclusion criteria that confirm the independence role of (HCV) infection to cause diastolic dysfunction. also, the presence of DM in addition to HCV infection add no more adverse effect on cardiovascular outcomes.