Tissue Doppler velocity is superior to displacement and strain mapping in predicting left ventricular reverse remodelling response after cardiac resynchronisation therapy

Yu, Cheuk‐Man; Zhang, Qing; Chan, Yat‐Sun; Chan, Chi‐Kin; Yip, Gabriel Wai-Kwok; Kum, Leo C.C.; Wu, Eugene B.; Lee, Alex; Lam, Yat‐Yin; Chan, Stewart Siu-Wa; Fung, Jeffrey Wing‐Hong

doi:10.1136/hrt.2005.083592

Cited by 93 publications

(66 citation statements)

References 34 publications

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“…Relative movements of the myocardial wall with reference to the Doppler probe are analyzed, whereas strain imaging or MRI-based velocities need no reference outside the myocardium and contain only a single velocity direction. This might partly explain why Doppler-derived systolic long-axis velocities can predict the prognosis after CRT better than systolic long-axis strain (19,20). In agreement with these considerations and our results, a recent study in dogs showed that either systolic circumferential strain or diastolic long-axis strain was a better predictor of improved LV function after CRT compared to systolic long-axis strain (21).…”

Section: Discussionmentioning

confidence: 99%

Magnetic resonance tissue phase mapping: Analysis of age‐related and pathologically altered left ventricular radial and long‐axis dyssynchrony

Föll

Jung²,

Germann

et al. 2011

Magnetic Resonance Imaging

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Purpose: To employ magnetic resonance tissue phase mapping (TPM) for the assessment of age-related left ventricular (LV) synchrony of radial and long-axis motion in healthy volunteers and in hypertensive heart disease, dilated cardiomyopathy (DCM), and left bundle branch block (LBBB).Materials and Methods: TPM (spatial/temporal resolution ¼ 1.3 Â 2.6 mm 2 /13.8 msec) was employed to measure radial and long-axis myocardial velocities in 58 healthy volunteers of three age groups and 37 patients (hypertensive, n ¼ 18; DCM, n ¼ 12; DCM and LBBB n ¼ 7). Regional times-to-peak velocities (TTP) in systole and diastole were derived for all LV segments. Four measures of dyssynchrony were defined as the standard deviation of systolic and diastolic TTP for radial and long-axis motion.Results: Systolic radial and diastolic long-axis dyssynchrony was increased (P < 0.01) in all patient groups compared to controls. Multiple regressions revealed a significant relationship of dyssynchrony with LV ejection fraction and mass for systolic radial (P < 0.001 resp. P ¼ 0.02), diastolic radial (P < 0.001 resp. P < 0.05), and long-axis (P < 0.001 resp. P ¼ 0.001) motion. Diastolic dyssynchrony correlated with the LV remodeling index (P < 0.05) and increased with age (P < 0.03). Systolic long-axis dyssynchrony was not influenced by disease or LV function. Conclusion:Radial systolic and long-axis diastolic dyssynchrony were the most sensitive markers for altered dyssynchrony in hypertensive heart disease or DCM. Future studies are needed to evaluate the diagnostic value of TPM-derived dyssynchrony parameters.

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Section: Discussionmentioning

confidence: 99%

Magnetic resonance tissue phase mapping: Analysis of age‐related and pathologically altered left ventricular radial and long‐axis dyssynchrony

Föll

Jung²,

Germann

et al. 2011

Magnetic Resonance Imaging

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“…Using 2-dimensional speckle tracking, a delay >130ms in time to peak systolic radial strain among 6 mid segments in parasternal short axis view predicted increase in EF >15% at 8 months after CRT (16). However, Yu and colleagues (17) reported that standard deviation in time to peak systolic TDI-derived strain in 12 segments did not predict the response to CRT.…”

Section: Strain Imagingmentioning

confidence: 97%

Selection of candidates for cardiac resynchronization therapy: late gadolinium enhanced cardiac magnetic resonance as a new and promising predictor of intraventricular dyssynchrony

Gürel¹,

Tigen²

2011

Anadolu Kardiyol Derg

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ÖZETKardiyak resenkronizasyon tedavisi (KRT) ventrikül içi ileti gecikmesi olan hastalar için önemli bir tedavi seçeneği olup, seçilmiş kalp yetmezliği hastalarında mortalite ve morbiditeyi azalttığı gösterilmiştir. Ventrikül içi gecikmeyi tanımlamak ve KRT adaylarını seçmek için, renkli doku Doppler ekokardiyografi ve benek takibi gibi, çeşitli ekokardiyografik yöntemler önerilmiştir. Bu dikkatlice seçilmiş hastaların yaklaşık %30'u yanıt vermediğine göre, KRT'ne yanıtın öngörücüleri hala araştırma konusu olarak kalmaya devam etmektedir. Son zamanlarda kardiyak manyetik rezonans (KMR) görüntülemelerdeki geç gadolinyum tutulumu tarafından gösterilen miyokardiyal fibrozis, hem intraventriküler dissenkroninin hem de KRT'ne cevabın gelecek vadeden öngörücüsü olarak gösterilmiştir. Bu derlemenin konusu, KRT adaylarını seçmede kullanılan majör ekokardiyografik yön-temler, bu konuda KMR tarafından saptanan kardiyak fibrozisin potansiyel rolü ve kardiyak fibrozisin intraventriküler dissenkroni varlığıyla muhtemel ilişkisidir. ( ABSTRACTCardiac resynchronization therapy (CRT) is an important therapeutic option for patients with intraventricular conduction delay and has been shown to reduce mortality and morbidity in selected heart failure patients. Several echocardiographic methods have been proposed to define intraventricular delay and to select candidates for CRT, such as color coded tissue Doppler echocardiography and speckle tracking. Since, up to 30% of these carefully selected patients do not receive benefit; predictors of response to CRT still remain a topic of ongoing investigations. Recently, myocardial fibrosis defined by late gadolinium enhancement on cardiac magnetic resonance (CMR) imaging has been introduced as promising predictor of both intraventricular dyssynchrony and response to CRT. The focus of the present review is the major echocardiographic modalities to select CRT candidates, the potential role of cardiac fibrosis detected by CMR in this respect, and the possible relation of it with the presence of intraventricular dyssynchrony.

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“…Several methods of quantifying deviations from synchronous movement have been proposed. The most common method was proposed by Yu, et al and involves calculating the standard deviation of the times to peak systolic velocity among the 12 regions of interest (SD-TVI) (Yu et al 2005;Yu et al 2006). A cut-off of 32 ms has been used to indicate clinically significant dyssynchrony (Yu et al 2005).…”

Section: Longitudinal Motionmentioning

confidence: 99%

Right Ventricular Pacing and Mechanical Dyssynchrony

Burns¹,

Gage²,

Bank³

2012

Electrophysiology - From Plants to Heart

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Tissue Doppler velocity is superior to displacement and strain mapping in predicting left ventricular reverse remodelling response after cardiac resynchronisation therapy

Abstract: Tissue velocity parameters of systolic asynchrony are superior to those of displacement and strain mapping in predicting LV reverse remodelling response after CRT.

Cited by 93 publications

References 34 publications

Magnetic resonance tissue phase mapping: Analysis of age‐related and pathologically altered left ventricular radial and long‐axis dyssynchrony

Magnetic resonance tissue phase mapping: Analysis of age‐related and pathologically altered left ventricular radial and long‐axis dyssynchrony

Selection of candidates for cardiac resynchronization therapy: late gadolinium enhanced cardiac magnetic resonance as a new and promising predictor of intraventricular dyssynchrony

Right Ventricular Pacing and Mechanical Dyssynchrony

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