Tissue effects of glucocorticoids

Baxter, John D.; Forsham, Peter H.

doi:10.1016/0002-9343(72)90154-4

Cited by 479 publications

(157 citation statements)

References 117 publications

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“…To our knowledge, no similar data are available for NEFA. Finally, these high concentrations of NEFA could be related to the stress induced by piglet weaning, since stress-related hormones are lipolytic [5]. However, our results did not show any clear increase in cortisol on the day of weaning, in contrast to findings from De Passille et al [15] and Tsuma et al [48].…”

Section: Metabolitescontrasting

confidence: 96%

“…Increase in plasma concentrations of glucose in L sows on the day of weaning was probably due to the cessation of the glucose uptake by the mammary gland [2,36,46]. Stress-related hormones may also be implicated, as they induced an increased production of glucose [5]. In H sows, these effects certainly also exist, but may be cancelled by the decrease in glucose concentrations induced by the reduction by 50 % of feed intake on the day of weaning.…”

Section: Metabolitesmentioning

confidence: 98%

“…Concentrations of IGF-I were determined in plasma using a double antibody RIA after an acid-ethanol extraction as previously described [29]. For insulin, the intra-and interassay CVs were 6.3 and 19.1 % at 167 pIU/mL, respectively, and for GH, 5 [10,27] or had no clear influence [12,33,50]. The difference in litter growth observed in our experiment could not be explained by differences in the amount of creep feed eaten by piglets during the fourth week of lactation (1.32 kg/litter from H sows and 1.17 kg/litter from L sows).…”

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confidence: 99%

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Influence of feed restriction in primiparous lactating sows on body condition and metabolic parameters

Quesnel¹,

Pasquier²,

Mounier³

et al. 1998

Reprod. Nutr. Dev.

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Section: Metabolitescontrasting

confidence: 96%

Section: Metabolitesmentioning

confidence: 98%

mentioning

confidence: 99%

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Influence of feed restriction in primiparous lactating sows on body condition and metabolic parameters

Quesnel¹,

Pasquier²,

Mounier³

et al. 1998

Reprod. Nutr. Dev.

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“…Glucocorticoids are known to have catabolic effects on muscle, skin, adipose and connective tissues, which results in decreased synthesis and increased degradation of protein and fat, and reduced glucose and amino acid uptake (53). Taken together, the reduced levels of glucocorticoids combined with increased levels of circulating insulin found in Calm animals may explain how they gained significantly more body mass than Cntl animals without increased energy intake per unit body mass.…”

Section: Discussionmentioning

confidence: 99%

The Calm Mouse: An Animal Model of Stress Reduction

Gurfein

Stamm

Bacchetti

et al. 2012

Mol Med

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Chronic stress is associated with negative health outcomes and is linked with neuroendocrine changes, deleterious effects on innate and adaptive immunity, and central nervous system neuropathology. Although stress management is commonly advocated clinically, there is insufficient mechanistic understanding of how decreasing stress affects disease pathogenesis. Therefore, we have developed a "calm mouse model" with caging enhancements designed to reduce murine stress. Male BALB/c mice were divided into four groups: control (Cntl), standard caging; calm (Calm), large caging to reduce animal density, a cardboard nest box for shelter, paper nesting material to promote innate nesting behavior, and a polycarbonate tube to mimic tunneling; control exercise (Cntl Ex), standard caging with a running wheel, known to reduce stress; and calm exercise (Calm Ex), calm caging with a running wheel. Calm, Cntl Ex and Calm Ex animals exhibited significantly less corticosterone production than Cntl animals. We also observed changes in spleen mass, and in vitro splenocyte studies demonstrated that Calm Ex animals had innate and adaptive immune responses that were more sensitive to acute handling stress than those in Cntl. Calm animals gained greater body mass than Cntl, although they had similar food intake, and we also observed changes in body composition, using magnetic resonance imaging. Together, our results suggest that the Calm mouse model represents a promising approach to studying the biological effects of stress reduction in the context of health and in conjunction with existing disease models.

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“…However, hormonal induced differentiation can be reversed by growth factors (Narve and Ringold, 1988) or by oncogenes (Andres et al, 1988;Vardimon et al, 1991). Glucocorticoids have antiproliferative effects: They inhibit proliferation of a variety of cultured cell lines (Hackney et al, 19701, block tumor promotion in the mouse skin carcinogenesis system (Belman and Troll, 1972;Scribner and Slaga, 1973), inhibit inflammatory processes, and limit the proliferative responses of cells in wound healing and chronic destructive diseases (Baxter and Forsham, 1972;Vassali et al, 1976;Liddle, 1981;Buetler et al, 1986;Allison, 1988). Thus, the signal transduction pathway that modulates gene expression and induces differentiation in response to hormones seems to be antagonistic to that which stimulates cell proliferation.…”

Section: Hypothesis and Commentsmentioning

confidence: 99%

Molecular control of glutamine synthetase expression in the developing retina tissue

Vardimon

Ben-Dror

Havazelet

et al. 1993

Developmental Dynamics

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Glutamine synthetase is a differentiation marker of the neural retina, whose expression is restricted to Muller glia cells, is inducible by glucocorticoids and is dependent on tissue development. The retina tissue acquires the competence to express GS in response to glucocorticoids with development, although the level of hormone binding activity in the cells does not alter with age. Using CAT constructs that are controlled by "simple GRE" promoters we demonstrated that glucocorticoid receptor transcription activity in retina cells increases with development. The increase in receptor activity correlates directly with the increase in inducibility of the glutamine synthetase gene and inversely with the rate of retina cell proliferation. At early developmental ages, when retina cells are still proliferating, the glucocorticoid receptor is transcriptionally inactive and glutamine synthetase expression cannot be induced. Receptor activity increases progressively with development and by day 12, when cell proliferation ceases, competence for glutamine synthetase induction is high. This competence for glutamine synthetase induction can be repressed by overexpressing the oncogene v-src, which stimulates retina cell proliferation. We discuss possible mechanisms for developmental-dependent modulation of glucocorticoid receptor transcriptional activity. 0 1993 Wiley-Liss, Inc.

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Tissue effects of glucocorticoids

Cited by 479 publications

References 117 publications

Influence of feed restriction in primiparous lactating sows on body condition and metabolic parameters

Influence of feed restriction in primiparous lactating sows on body condition and metabolic parameters

The Calm Mouse: An Animal Model of Stress Reduction

Molecular control of glutamine synthetase expression in the developing retina tissue

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