Tissue Engineered Cartilage with Cultured Chondrocytes and a Collagen Sponge Matrix

Klemt, C.

doi:10.1007/978-3-642-60309-9_20

Cited by 5 publications

(8 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Generell sind offenporige Matrixmaterialien mit interkonnektierenden Poren von 100±200 mm Durchmesser in Verwendung, die in einer bestimmten dreidimensionalen Form vorgefertigt werden [2,15,27]. Generell sind offenporige Matrixmaterialien mit interkonnektierenden Poren von 100±200 mm Durchmesser in Verwendung, die in einer bestimmten dreidimensionalen Form vorgefertigt werden [2,15,27].…”

Section: Biomaterialienunclassified

“…Eigene Untersuchungen zeigten eine gegenwärtige Überlegenheit der biogenen Materialien bei der Knorpel-und Knochenneubildung [15,27]. Primäre humane Chondrozyten synthetisierten in Kollagenvliesen eine neue Knorpelmatrix aus Kollagen Typ 2 und bildeten im ektopen Tiermodell Knorpelgewebe (Abb.…”

Section: Biomaterialienunclassified

“…Experimentell hat sich die Verwendung primärer humaner Chondrozyten aus hyalinem Rippenknorpel zur Gelenkknorpelrekonstruktion durch Tissue Engineering bewährt [15]. Eine Biopsie wird zerkleinert und enzymatisch die Knorpelmatrix digestiert, so daû nach 24 Std.…”

Section: Knorpelrekonstruktionunclassified

“…Wichtige Prinzipien sind die Implantation von Biomaterialien mit zum einen induktiven Proteinen [29,32] bzw. deren Gensequenzen [20] oder zum anderen histogenen Zellen [2,4,11,14,15,26,28,30]. Beide Prinzipien ± Induktion bzw.…”

Section: Diskussionunclassified

See 3 more Smart Citations

Tissue Engineering mit mesenchymalen Stammzellen zur Knorpel- und Knochenneubildung

Schaefer¹,

Klemt

Zhang³

et al. 2000

Chirurg

Self Cite

View full text Add to dashboard Cite

Tissue engineering offers the possibility to fabricate living substitutes for tissues and organs by combining histogenic cells and biocompatible carrier materials. Pluripotent mesenchymal stem cells are isolated and subcultured ex vivo and then their histogenic differentiation is induced by external factors. The fabrication of bone and cartilage constructs, their combinations and gene therapeutic approaches are demonstrated. Advantages and disadvantages of these methods are described by in vitro and in vitro testing. The proof of histotypical function after implantation in vivo is essential. The use of autologous cells and tissue engineering methods offers the possibility to overcome the disadvantages of classical tissue reconstruction--donor site morbidity of autologous grafts, immunogenicity of allogenic grafts and loosening of alloplastic implants. Furthermore, tissue engineering widens the spectrum of surgical indications in bone and cartilage reconstruction.

show abstract

Section: Biomaterialienunclassified

Section: Knorpelrekonstruktionunclassified

Section: Diskussionunclassified

See 2 more Smart Citations

Tissue Engineering mit mesenchymalen Stammzellen zur Knorpel- und Knochenneubildung

Schaefer¹,

Klemt

Zhang³

et al. 2000

Chirurg

Self Cite

View full text Add to dashboard Cite

show abstract

“…[1], [2]). Although difficulties with cartilage structure and integration still persist, techniques using combined grafts using cancellous bone and autologous cartilage are approaching clinical application ( [3], [4], [5]).…”

Section: Introductionmentioning

confidence: 99%

Computer-Assisted Ankle Joint Arthroplasty Using Bio-engineered Autografts

Sidler

Köstler

Bardyn

et al. 2005

Lecture Notes in Computer Science

View full text Add to dashboard Cite

Abstract. Bio-engineered cartilage has made substantial progress over the last years. Preciously few cases, however, are known where patients were actually able to benefit from these developments. In orthopaedic surgery, there are two major obstacles between in-vitro cartilage engineering and its clinical application: successful integration of an autologuous graft into a joint and the high cost of individually manufactured implants. Computer Assisted Surgery techniques can potentially address both issues at once by simplifying the therapy, allowing pre-fabrication of bone grafts according to a shape model, individual operation planning based on CT images and providing optimal accuracy during the intervention. A pilot study was conducted for the ankle joint, comprising a simplified rotational symmetric bone surface model, a dedicated planning software and a complete cycle of treatment on one cadaveric human foot. The outcome was analysed using CT and MRI images; the post-operative CT was further segmented and registered with the implant shape to prove the feasibility of computer assisted arthroplasty using bio-engineered autografts.

show abstract

Computer Assisted Orthopaedic Surgery

Lin¹,

Samchukov²,

Birch

2006

Int J CARS

View full text Add to dashboard Cite

Ultrasound examinations in the shoulder area are nowadays usually limited to evaluating conventional, two-dimensional (2D) images acquired in predefined, standardized acquisition orientations This greatly restricts the field of view which is thus provided to inspect the three-dimensional (3D) geometry of the joint and places high demands on the physician's ability to correctly place the scanhead and interpret the images. When considering ultrasound imaging for use in a surgical planning scenario, e.g. for the implantation of the humeral part of a shoulder prosthesis, the conventional, 2D imaging technique must be extended to three dimensions; a (semi-) automatic segmentation as well as interpretation, i.e. for determining 3D measures which can be utilized in the planning process, is also desired. In this study, we evaluated the feasibility of a purely 3D ultrasound based approach for the navigated, anatomically optimized implantation of the humeral part of a shoulder prosthesis. Keywords 3D ultrasound AE Shoulder endoprosthesis AE Navigated implantation 1 Introduction Surgical planning for shoulder joint replacements is nowadays usually performed based two-dimensional (2D) X-Ray imaging or -when deemed necessary -on additional CT or MRI imaging. Apart from being time consuming and expensive, X-Ray imaging as well as CT also expose the patient to ionizing radiation. On the other hand, conventional, 2D sonography of the shoulder joint is a well-established, standardized and cost-effective method and is commonly used for various diagnostic evaluations in several so called standard acquisition orientations [1]. Nevertheless, by using a 2D technique to depict the joint's three-dimensional (3D) anatomy, a number of limitations become apparent: every investigation highly depends on the physician's abilities to correctly place the scanhead and to interpret the recorded images. This can lead to a considerable variability in the diagnostic results [2]. Determining 3D measures from 2D data -which is a prerequisite for applying ultrasound imaging techniques for use in surgical planning -is impossible. For making use of sonography's full potential, technical improvements such as 3D freehand acquisition of ultrasound volumes coupled with a (semi-) automatic segmentation and interpretation of the reconstructed volume data become a necessity. In this study, we evaluated the use of freehand acquired ultrasound volumes for their applicability in surgical planning and navigated implantation of the humeral part of a shoulder endoprosthesis. 2 Materials and methods Image volumes of the upper arms of several healthy volunteers (containing between 1,000 and 1,500 slices each) were acquired in several overlapping, manually controlled freehand sweeps using a conventional 2D ultrasound imaging system (Nemio TM SSA-550A, Toshiba, Tokyo, Japan); a localizer system (6 DOF, Polaris TM , Northern Digital Inc., Waterloo, ON, Canada) was fixed to the transducer. To ensure geometric accuracy, a calibration was performed to establish the rigid bod...

show abstract

Tissue Engineered Cartilage with Cultured Chondrocytes and a Collagen Sponge Matrix

Cited by 5 publications

References 5 publications

Tissue Engineering mit mesenchymalen Stammzellen zur Knorpel- und Knochenneubildung

Tissue Engineering mit mesenchymalen Stammzellen zur Knorpel- und Knochenneubildung

Computer-Assisted Ankle Joint Arthroplasty Using Bio-engineered Autografts

Computer Assisted Orthopaedic Surgery

Contact Info

Product

Resources

About