2012
DOI: 10.1159/000339606
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Tissue-Engineered Devices in Cardiovascular Surgery

Abstract: Manufacturing life-long functional cardiovascular (CV) implants is the ultimate goal for researchers and clinicians in the cardiothoracic field. Tissue engineering (TE) is an opportunity to create ideal prostheses that are vital, growing, adaptive, autologous and functionally optimally performing. Today, initial translation from basic science to first clinical trials has begun. The article depicts the state of the art in TE techniques for CV products and describes milestones in the ongoing development of tissu… Show more

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Cited by 20 publications
(12 citation statements)
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“…Therefore, improvements in PCL structural fabrication, the implementation of textile‐reinforcement strategies as well as more intense and valve‐specific mechanical tests are strongly required (Nottelet et al ., ; Gaumer et al ., ; Wang et al ., ; Sant and Khademhosseini, ; Baker et al ., ; Peroglio et al ., ; Sarkar et al ., ; Koch et al ., ; Eshraghi and Das, ; Lebourg et al ., ). Although PCL fabrication can undoubtedly be enhanced, the appropriateness of PCL, especially for valvular TE, has to be questioned and alternative biodegradable scaffold materials, such as polyglycolide, polylactide, polyhydroxybutyrate, polydioxanone, polyesteramide or polyurethane, need to be tested (Klopsch and Steinhoff, ).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Therefore, improvements in PCL structural fabrication, the implementation of textile‐reinforcement strategies as well as more intense and valve‐specific mechanical tests are strongly required (Nottelet et al ., ; Gaumer et al ., ; Wang et al ., ; Sant and Khademhosseini, ; Baker et al ., ; Peroglio et al ., ; Sarkar et al ., ; Koch et al ., ; Eshraghi and Das, ; Lebourg et al ., ). Although PCL fabrication can undoubtedly be enhanced, the appropriateness of PCL, especially for valvular TE, has to be questioned and alternative biodegradable scaffold materials, such as polyglycolide, polylactide, polyhydroxybutyrate, polydioxanone, polyesteramide or polyurethane, need to be tested (Klopsch and Steinhoff, ).…”
Section: Discussionmentioning
confidence: 99%
“…However, endothelial engraftment is fibrinolysis‐dependent and can stabilize fibrin with tissue organization in vivo (Koolwijk et al ., ). Moreover, early endothelial cellularization and fibrin surface coating could reduce the thrombogenicity of the ECM structures below (Klopsch and Steinhoff, ; Lopez‐Vilchez et al ., ; Crawley and Lane, ). Consequently, the risks or benefits of pharmacological strengthening of fibrin for the intravascular application remain unclear (Horvath et al ., ).…”
Section: Discussionmentioning
confidence: 99%
“…The most important described application were the arterial occlusive disease such coronorapathy and ischemic periferical condition treated with artery by-pass [16]. Furthermore were described use also in thoracic surgery and for dialysis access [17,18].…”
Section: Bioengineered Vessel: Definition and Developmentmentioning
confidence: 99%
“…Such constructs have been tested in animal models and few of them have also reached clinical trials, however, they tend to degenerate, dilate, and calcify after implantation. 7,9 The reader is referred to excellent reviews in the field. 7,[9][10][11] Acellular biological tissues are considered excellent scaffolds, which exhibit adequate biological, mechanical, and handling properties.…”
Section: Introductionmentioning
confidence: 99%
“…7,9 The reader is referred to excellent reviews in the field. 7,[9][10][11] Acellular biological tissues are considered excellent scaffolds, which exhibit adequate biological, mechanical, and handling properties. We hypothesized that chemically stabilized and anti-calcification-treated acellular arteries would be ideal scaffolds for development of vascular grafts for peripheral surgery applications.…”
Section: Introductionmentioning
confidence: 99%