Tissue-Engineered Flexible Ear-Shaped Cartilage

Xu, Jiake; Johnson, Timothy S.; Motarjem, Pejman; Peretti, Giuseppe M.; Randolph, Mark A.; Yaremchuk, Michael J.

doi:10.1097/01.prs.0000161465.21513.5d

Cited by 80 publications

(52 citation statements)

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“…Elastin(-like) biomaterials have been suggested for a wide variety of applications, including skin substitutes [187], vascular grafts [188], heart valves [189], and elastic cartilage [190]. In this section, we will focus on skin, tubular constructs (for vascular grafts) and self-assembling materials.…”

Section: Applications Of Elastin As a Biomaterialsmentioning

confidence: 99%

Elastin as a biomaterial for tissue engineering

et al. 2007

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Section: Applications Of Elastin As a Biomaterialsmentioning

confidence: 99%

Elastin as a biomaterial for tissue engineering

et al. 2007

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“…These methods have been used for engineering of elastic and nonarticular cartilage such as auricle [7,21,41], nose [8,21], and tympanic membrane [17]. Several shaped osteochondral constructs containing articular cartilaginous sections, for phalanx [20,35] and mandibular condyle [1], for example, have been fabricated.…”

Section: Discussionmentioning

confidence: 99%

Shaped, Stratified, Scaffold-free Grafts for Articular Cartilage Defects

Han

Bae

Hsieh-Bonassera

et al. 2008

Clin Orthop Relat Res

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One goal of treatment for large articular cartilage defects is to restore the anatomic contour of the joint with tissue having a structure similar to native cartilage. Shaped and stratified cartilaginous tissue may be fabricated into a suitable graft to achieve such restoration. We asked if scaffold-free cartilaginous constructs, anatomically shaped and targeting spherically-shaped hips, can be created using a molding technique and if biomimetic stratification of the shaped constructs can be achieved with appropriate superficial and middle/deep zone chondrocyte subpopulations. The shaped, scaffold-free constructs were formed from the alginate-released bovine calf chondrocytes with shaping on one (saucer), two (cup), or neither (disk) surfaces. The saucer and cup constructs had shapes distinguishable quantitatively (radius of curvature of 5.5 ± 0.1 mm for saucer and 2.8 ± 0.1 mm for cup) and had no adverse effects on the glycosaminoglycan and collagen contents and their distribution in the constructs as assessed by biochemical assays and histology, respectively. Biomimetic stratification of chondrocyte subpopulations in saucer-and cup-shaped constructs was confirmed and quantified using fluorescence microscopy and image analysis. This shaping method, combined with biomimetic stratification, has the potential to create anatomically contoured large cartilaginous constructs.

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“…Being one of the major constituents of the vessel wall, much of the work on electrospun elastin is for vascular graft applications, however, other studies have used elastin for applications such as skin [76], heart valves [77], and elastic cartilage [78].…”

Section: Electrospinning Elastinmentioning

confidence: 99%

The Use of Natural Polymers in Tissue Engineering: A Focus on Electrospun Extracellular Matrix Analogues

et al. 2010

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Natural polymers such as collagens, elastin, and fibrinogen make up much of the body's native extracellular matrix (ECM). This ECM provides structure and mechanical integrity to tissues, as well as communicating with the cellular components it supports to help facilitate and regulate daily cellular processes and wound healing. An ideal tissue engineering scaffold would not only replicate the structure of this ECM, but would also replicate the many functions that the ECM performs. In the past decade, the process of electrospinning has proven effective in creating non-woven ECM analogue scaffolds of micro to nanoscale diameter fibers from an array of synthetic and natural polymers. The ability of this fabrication technique to utilize the aforementioned natural polymers to create tissue engineering scaffolds has yielded promising results, both in vitro and in vivo, due in part to the enhanced bioactivity afforded by materials normally found within the human body. This review will present the process of electrospinning and describe the use of natural polymers in the creation of bioactive ECM analogues in tissue engineering.

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Tissue-Engineered Flexible Ear-Shaped Cartilage

Cited by 80 publications

References 0 publications

Elastin as a biomaterial for tissue engineering

Elastin as a biomaterial for tissue engineering

Shaped, Stratified, Scaffold-free Grafts for Articular Cartilage Defects

The Use of Natural Polymers in Tissue Engineering: A Focus on Electrospun Extracellular Matrix Analogues

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