Tissue-Engineered Larynx: Future Applications in Laryngeal Cancer

Hamilton, Nicholas; Birchall, Martin A.

doi:10.1007/s40136-017-0144-6

Cited by 17 publications

(17 citation statements)

References 70 publications

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“…Standard treatments for advanced cancer, which involve surgical resection and/or chemoradiation, are life‐saving but may render patients dependent on a tracheostomy and/or feeding tube with poor quality of life. A recent review by Hamilton and Birchall indicated that one treatment strategy for advanced laryngeal cancer is to tissue engineer a functional laryngeal replacement . This, they postulate, can be broken down into a number of design considerations, including restoration of 1) structure through scaffold design and 2) function by promoting skeletal muscle regeneration with associated vascularization and innervation.…”

Section: Introductionmentioning

confidence: 99%

Motor endplate‐expressing cartilage‐muscle implants for reconstruction of a denervated hemilarynx

Brookes¹,

Voytik‐Harbin

Zhang³

et al. 2018

The Laryngoscope

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Objective Tissue engineering of the larynx requires a complex, multiple tissue layer design. Additionally, spontaneous reinnervation of the larynx after recurrent laryngeal nerve (RLN) injury is often disorganized, resulting in subpar function. This study investigates use of tissue‐engineered cartilage and motor endplate‐expressing (MEE) tissue‐engineered skeletal muscle implants for laryngeal reconstruction and the promotion of organized reinnervation after RLN injury. Methods F344 rat primary muscle progenitor cells (MPCs) were isolated. Three‐dimensional muscle constructs were created by encapsulating MPCs in type I oligomeric collagen under passive tension. Constructs were then cultured in differentiation medium (MPC control constructs) or induced to form motor endplates (MEE constructs) with neurotrophic agents. Three‐dimensional cartilage constructs were created with adipose stem cells differentiated in chondrocyte medium. The muscle and cartilage constructs were implanted into surgically created myochondral defects in the F344 rat larynx with injured or intact (control) RLN. At 1‐, 3‐, and 6‐month timepoints, videolaryngoscopy, electromyography (EMG), histology, and immunohistochemistry were used to assess outcomes. Results At all timepoints, cartilage‐muscle implants were well integrated into host tissue. Functionally, there was increased vocal fold adduction and EMG activity in nerve‐injured rats treated with the MEE constructs when compared to those treated with the MPC control constructs. Motor endplate‐expressing constructs had increased myofiber cross‐sectional area compared to MPC control constructs. Conclusion Although our laboratory previously demonstrated that muscle and cartilage constructs could be used separately for hemilaryngeal reconstruction, this study suggests combining them with the modification of MEEs rather than MPCs, resulting in improved muscle recovery after recurrent laryngeal nerve injury. Level of Evidence NA Laryngoscope, 129:1293–1300, 2019

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Section: Introductionmentioning

confidence: 99%

Motor endplate‐expressing cartilage‐muscle implants for reconstruction of a denervated hemilarynx

Brookes¹,

Voytik‐Harbin

Zhang³

et al. 2018

The Laryngoscope

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“…Currently, the restoration of laryngeal function after partial or total laryngectomy is only partly possible and is associated with major impairment for the patients. Hamilton and Birchall state in a recent review article that the treatment of laryngeal cancer will be crucially influenced by the developments in the field of laryngeal regeneration over the next 10 years 92 . Larynx transplantation is currently mainly a theoretical option that can only be applied in exceptional cases and that is not suitable for reconstruction after tumor surgery.…”

Section: Regenerative Procedures In Otorhinolaryngology – State-ofmentioning

confidence: 99%

Regeneration – eine neue therapeutische Dimension in der Hals-Nasen-Ohrenheilkunde

Rotter

Zenobi‐Wong

2018

Laryngo-Rhino-Otol

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ZusammenfassungDie Regeneration als therapeutisches Prinzip und damit die Regenerative Medizin ist ein vielversprechender Ansatz künftig die therapeutischen Optionen der Hals-Nasen-Ohrenheilkunde um eine weitere Dimension zu erweitern. Während heute rekonstruktive chirurgische Verfahren, Medikamente und Prothesen wie bspw. das Cochlea Implantat die Funktionen defekter Gewebe im Kopf-Hals-Bereich ersetzen, sollen durch die Regenerative Medizin die defekten Gewebe und deren Funktion selbst wiederhergestellt werden. In dieser Übersichtsarbeit werden neue Entwicklungen wie das 3D-Bioprinting und dezellularisierte, natürliche Biomaterialien für regenerative Ansätze vorgestellt und durch eine Zusammenstellung aktueller präklinischer und klinischer Studien im Bereich der Regenerativen Medizin in der Hals-Nasen-Ohrenheilkunde ergänzt.

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“…27 The concept of transplanting a biocompatible cartilage scaffold covered in the patient's own epithelium, which integrates with the host tissue thereby negating the rejection process, would revolutionize the treatment of laryngeal cancer and improve the prospect of organ and functional preservation. 28 There are multiple challenges which exist, however, before this concept can be transferred into clinical practice, and this may take at least another 10 years to see fruition.…”

Section: Tissue-engineered Larynxmentioning

confidence: 99%

New Developments in the Management of Laryngeal Cancer

Mirza¹,

Loughran²

2017

International Journal of Head and Neck Surgery

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Laryngeal cancer remains one of the most common airway cancers. Although the incidence has generally declined, the overall survival has actually decreased over the last 40 years despite advancements in its treatment. Treating a malignancy in this region is challenging, and management involves a balance between primary oncological control, organ and functional preservation, and minimizing treatment morbidity. Patients with laryngeal cancer require a truly multidisciplinary team approach. Surgery remains an integral part of management, with several viable organ preservation-based surgical approaches evolving over recent years. There have also been significant advancements in other nonsurgical laryngeal preservation treatment modalities, such as radiation and chemotherapy. However, there still remains a need for further research in understanding the disease, and more innovation in its treatment. Future research in the treatment of laryngeal cancer should be focused on strategies to improve locoregional control and overall survival, while reducing patient morbidity and the impact on quality of life.

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Tissue-Engineered Larynx: Future Applications in Laryngeal Cancer

Cited by 17 publications

References 70 publications

Motor endplate‐expressing cartilage‐muscle implants for reconstruction of a denervated hemilarynx

Motor endplate‐expressing cartilage‐muscle implants for reconstruction of a denervated hemilarynx

Regeneration – eine neue therapeutische Dimension in der Hals-Nasen-Ohrenheilkunde

New Developments in the Management of Laryngeal Cancer

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