Tissue-engineered small-diameter vascular grafts containing novel copper-doped bioactive glass biomaterials to promote angiogenic activity and endothelial regeneration

Alasvand, Neda; Behnamghader, Aliasghar; Milan, Peiman Brouki; Simorgh, Sara; Mobasheri, Ali; Mozafari, Masoud

doi:10.1016/j.mtbio.2023.100647

Cited by 17 publications

(9 citation statements)

References 78 publications

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“…Cu 2+ ions also regulate bone metabolism and accelerate the rate of wound healing, showing similar effects to those observed for Zn 2+ [5]. In addition, Cu is a proangiogenic and antibacterial agent [154]. Cu deficiency is a rare condition linked to several diseases, such as anemia, neutropenia, and bone alterations due to altered osteogenesis [155].…”

Section: Coppermentioning

confidence: 75%

Carnosine, Zinc and Copper: A Menage a Trois in Bone and Cartilage Protection

Ciaffaglione,

Rizzarelli

2023

IJMS

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Dysregulated metal homeostasis is associated with many pathological conditions, including arthritic diseases. Osteoarthritis and rheumatoid arthritis are the two most prevalent disorders that damage the joints and lead to cartilage and bone destruction. Recent studies show that the levels of zinc (Zn) and copper (Cu) are generally altered in the serum of arthritis patients. Therefore, metal dyshomeostasis may reflect the contribution of these trace elements to the disease’s pathogenesis and manifestations, suggesting their potential for prognosis and treatment. Carnosine (Car) also emerged as a biomarker in arthritis and exerts protective and osteogenic effects in arthritic joints. Notably, its zinc(II) complex, polaprezinc, has been recently proposed as a drug-repurposing candidate for bone fracture healing. On these bases, this review article aims to provide an overview of the beneficial roles of Cu and Zn in bone and cartilage health and their potential application in tissue engineering. The effects of Car and polaprezinc in promoting cartilage and bone regeneration are also discussed. We hypothesize that polaprezinc could exchange Zn for Cu, present in the culture media, due to its higher sequestering ability towards Cu. However, future studies should unveil the potential contribution of Cu in the beneficial effects of polaprezinc.

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Section: Coppermentioning

confidence: 75%

Carnosine, Zinc and Copper: A Menage a Trois in Bone and Cartilage Protection

Ciaffaglione,

Rizzarelli

2023

IJMS

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“…Hemolysis is a detrimental process marked by the breakdown of red blood cells (RBCs) in the presence of abnormalities in the blood. These abnormalities could be caused by the introduction of a harmful foreign substance into the bloodstream, and therefore, it is crucial to conduct a material compatibility test with blood cells prior to clinical use . As per the ISO 10993–4 standard, the permissible hemolytic level for biomaterials is 5% and the percentage hemolysis was within this range in the case of PU–PGACL + GA films.…”

Section: Resultsmentioning

confidence: 99%

“…The multilayered vascular grafts were fabricated using electrospinning, which is the most preferred technique employed for this application. − The backbone of the graft (middle layer) is composed of slow-degrading poly(caprolactone) and fast-degrading poly(glycolic acid) to specifically tune the degradation and mechanical strength of the construct. Also, both the polymers employed for this purpose are Food and Drug Administration (FDA) approved, which is beneficial for the fabrication of implants intended for clinical purposes.…”

Section: Resultsmentioning

confidence: 99%

“…These abnormalities could be caused by the introduction of a harmful foreign substance into the bloodstream, and therefore, it is crucial to conduct a material compatibility test with blood cells prior to clinical use. 26 As per the ISO 10993−4 standard, the permissible hemolytic level for biomaterials is 5% 50 and the percentage hemolysis was within this range in the case of PU−PGACL + GA films. These results depict the blood compatibility of the material and thereby support its application as a vascular graft.…”

Section: Protein Adsorptionmentioning

confidence: 97%

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Antioxidant and Trilayered Electrospun Small-Diameter Vascular Grafts Maintain Patency and Promote Endothelialisation in Rat Femoral Artery

Das,

Nikhil,

Kumar

2024

ACS Biomater. Sci. Eng.

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Vascular grafts with a small diameter encounter inadequate patency as a result of intimal hyperplasia development.In the current study, trilayered electrospun small-diameter vascular grafts (PU−PGACL + GA) were fabricated using a poly(glycolic acid) and poly(caprolactone) blend as the middle layer and antioxidant polyurethane with gallic acid as the innermost and outermost layers. The scaffolds exhibited good biocompatibility and mechanical properties, as evidenced by their 6 MPa elastic modulus, 4 N suture retention strength, and 2500 mmHg burst pressure. Additionally, these electrospun grafts attenuated cellular oxidative stress and demonstrated minimal hemolysis (less than 1%). As a proof-of-concept, the preclinical evaluation of the grafts was carried out in the femoral artery of rodents, where the conduits demonstrated satisfactory patency. After 35 days of implantation, ultrasound imaging depicted adequate blood flow through the grafts, and the computed vessel diameter and histological staining showed no significant stenosis issue. Immunohistochemical analysis confirmed matrix deposition (38% collagen I and 16% elastin) and cell infiltration (42% for endothelial cells and 55% for smooth muscle cells) in the explanted grafts. Therefore, PU−PGACL + GA showed characteristics of a clinically relevant smalldiameter vascular graft, facilitating re-endothelialization while preserving the anticoagulant properties of the synthetic blood vessels.

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“…500,501 Moreover, the tunable chemical composition of BGs and silicate ceramics offers great possibilities to introduce other distinctive features in various inorganic/organic biomaterials, such as antibacterial effects, anticoagulant ability, and angiogenic property. 502–511 The surface topographies and micro/nanostructures of the silicon-composed coating also influence the bioactivities of the modified biomaterials. 512,513 Jo et al proposed a diatom-inspired silica nanoparticle coating method for the surface functionalization of titanium implants (Fig.…”

Section: Multi-dimensional Design and Materials Science Of Silicon-co...mentioning

confidence: 99%

Silicon-containing nanomedicine and biomaterials: materials chemistry, multi-dimensional design, and biomedical application

Chen,

Zhang,

Duan

et al. 2024

Chem. Soc. Rev.

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Tissue-engineered small-diameter vascular grafts containing novel copper-doped bioactive glass biomaterials to promote angiogenic activity and endothelial regeneration

Cited by 17 publications

References 78 publications

Carnosine, Zinc and Copper: A Menage a Trois in Bone and Cartilage Protection

Carnosine, Zinc and Copper: A Menage a Trois in Bone and Cartilage Protection

Antioxidant and Trilayered Electrospun Small-Diameter Vascular Grafts Maintain Patency and Promote Endothelialisation in Rat Femoral Artery

Silicon-containing nanomedicine and biomaterials: materials chemistry, multi-dimensional design, and biomedical application

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