Tissue Engineering and Regenerative Medicine: Recent Innovations and the Transition to Translation

Fisher, Matthew B.; Mauck, Robert L.

doi:10.1089/ten.teb.2012.0723

Cited by 227 publications

(154 citation statements)

References 105 publications

(89 reference statements)

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“…In this sense, tissue 16 engineering (TE) (Fisher and Mauck, 2013;Langer and Vacanti, 17 1993) has played a key role as it has introduced new strategies 18 based on the development of composite systems that integrate 19 cells, growth factors, and scaffolds, (Drosse et al, 2008;Eisenbarth, 20 2007; Vallet-Regí and Ruiz-Hernández, 2011) avoiding major 21 drawbacks associated to autografts and allografts (O'Brien, 2011). 22 TE develops substrates that restore, maintain or improve the 23 function of damaged tissues (Langer, 2000).…”

Section: Introductionmentioning

confidence: 99%

Tuning dual-drug release from composite scaffolds for bone regeneration

Paris

Román

Manzano

et al. 2015

International Journal of Pharmaceutics

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Keywords:Dual-drug delivery system Designed porous scaffold Ibuprofen Zoledronic acid Co-delivery release Tissue engineering A B S T R A C TThis work presents the tuning of drug-loaded scaffolds for bone regeneration as dual-drug delivery systems. Two therapeutic substances, zoledronic acid (anti-osteoporotic drug) and ibuprofen (antiinflammatory drug) were successfully incorporated in a controlled manner into three dimensional designed porous scaffolds of apatite/agarose composite. A high-performance liquid chromatography method was optimized to separate and simultaneously quantify the two drugs released from the dualdrug codelivery system. The multifunctional porous scaffolds fabricated show a very rapid delivery of anti-inflammatory (interesting to reduce inflammation after implantation), whereas the antiosteoporotic drug showed sustained release behaviour (important to promote bone regeneration). Since ibuprofen release was faster than desired, this drug was encapsulated in chitosan spheres which were then incorporated into the scaffolds, obtaining a release profile suitable for clinical application. The results obtained open the possibility to simultaneously incorporate two or more drugs to an osseous implant in a controlled way improving it for bone healing application.2015 Published by Elsevier B.V. 7

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Section: Introductionmentioning

confidence: 99%

Tuning dual-drug release from composite scaffolds for bone regeneration

Paris

Román

Manzano

et al. 2015

International Journal of Pharmaceutics

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“…Эти клетки обычно трансплантируются в трехмерные пористые скаффолды, обеспечивающие необхо-димую внеклеточную среду, которая содержит физические и химические сигналы для развития и регенерации ткани [15]. Несмотря на то что в течение ряда лет разрабатывались стратегии, основанные на различных типах биоматериалов и стволовых клеток, современная тканевая ин-женерия не нашла широкого применения в кли-нических условиях [20,26]. Для достижения этой цели потребуется глубокое понимание нормаль-ных физиологических процессов развития тканей и механизмов, лежащих в основе взаимодействия между МСК и биоматериалами во время ткане-образования, поскольку многие важные детали остаются неясными [17].…”

Section: заключениеunclassified

“…В доклинических исследованиях показано, что заселение биосовместимых материалов МСК значительно повышает остеокондуктивность и улучшает интеграцию имплантатов [30,38]. Первые клинические испытания скаффолдов, заселенных МСК, подтверждают их эффектив-ность [20]. Это свидетельствует о перспективно-сти использования тканеинженерных конструк-ций, полученных на основе биосовместимых скаффолдов, заселенных МСК для регенерации костей.…”

Section: заключениеunclassified

Role of Mesenchymal Multipotent Stromal Cells in Remodeling of Bone Defects

Киселевский¹,

Anisimova²,

Должикова³

et al. 2018

Med. immunol.

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“…Therefore, as an interdisciplinary field, tissue engineering concerns the development of biological substitutes capable of replacing or repairing diseased or damaged tissue and organs in humans [1][2][3][4] . Since the 80's, and especially in the last decade, tissue engineering and regenerative medicine have been proving its importance and potential to revolutionize important areas of medicine [1][2][3][4] , such as cardiovascular [5][6] , skin regeneration 7 and bone treatments [8][9][10][11] . Replacement tissues can be produced by first seeding human cells onto scaffolds [1][2][3][4] .…”

Section: Introductionmentioning

confidence: 99%

Preparation, Characterization and Biological Studies of Β-TCP and Β-TCP/Al2O3 Scaffolds Obtained by Gel-Casting of Foams

et al. 2017

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Replacement tissues for tissue engineering can be produced by seeding human cells onto scaffolds. In order to guarantee adequate bio-compatibility, porosity and mechanical resistance for promoting cellular growth, proliferation and differentiation within scaffold structures, it is necessary to investigate and improve materials and processing routes. β-tricalcium phosphate can be considered a very suitable bio-ceramic material for bone therapy because of its biocompatibility, osteo-conductivity and neovascularization potential. Alumina is commonly used as a sintering additive. In this study, β-TCP and β-TCP/Al 2 O 3 scaffolds were obtained by gel-casting method. The scaffolds showed high porosity (86-88%) and pore sizes ranging from 200 to 500 μm. Even though alumina did not promote improvement in β-TCP/Al 2 O 3 scaffolds in terms of mechanical performance, they showed great cytocompatibility as there was no cytotoxic and genotoxic effect. Therefore, β-TCP and β-TCP/Al 2 O 3 scaffolds are good candidates for application in tissue engineering.

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Tissue Engineering and Regenerative Medicine: Recent Innovations and the Transition to Translation

Cited by 227 publications

References 105 publications

Tuning dual-drug release from composite scaffolds for bone regeneration

Tuning dual-drug release from composite scaffolds for bone regeneration

Role of Mesenchymal Multipotent Stromal Cells in Remodeling of Bone Defects

Preparation, Characterization and Biological Studies of Β-TCP and Β-TCP/Al2O3 Scaffolds Obtained by Gel-Casting of Foams

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