Tissue engineering applications

López-Ângulo, Daniel; Bonilla, Jeannine; Sobral, Paulo José do Amaral

doi:10.1016/b978-0-12-824364-0.00028-9

Cited by 1 publication

(2 citation statements)

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“…Coating the metallic implants with hydroxyapatite (HAP), a basic calcium phosphate, can ensure the bonding between the metal and host tissues 11,12 . In addition, the organic–inorganic HAP biocomposites reinforced with biopolymers and/or metal oxides were proposed as a way to overcome the limitations of practical applications of HAP 13–16 . Thereby, composite coatings of HAP onto 316L stainless steel have been found to improve mechanical properties, 17,18 corrosion protection, 19–21 bioactivity, and biocompatibility of the metal implants 22–25 …”

Section: Introductionmentioning

confidence: 99%

“…11,12 In addition, the organic-inorganic HAP biocomposites reinforced with biopolymers and/or metal oxides were proposed as a way to overcome the limitations of practical applications of HAP. [13][14][15][16] Thereby, composite coatings of HAP onto 316L stainless steel have been found to improve mechanical properties, 17,18 corrosion protection, [19][20][21] bioactivity, and biocompatibility of the metal implants. [22][23][24][25] However, there are not many works that have studied the properties and behavior of the uncoated 316L in a biological or physiological environment simulated to human body such as minimum essential medium-alpha (α-MEM).…”

Section: Introductionmentioning

confidence: 99%

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Effect of the culture medium on the behavior of the austenitic stainless steel with the specific 316L grade

Sidane

Khireddine

2023

Surface & Interface Analysis

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The use of 316L stainless steel as an orthopedic bone plate material or as a substrate for coating implies the need to study its properties in a biological medium simulating human body environment. Therefore, the aim of this work is to investigate the microstructural characteristics, corrosion resistance, and mechanical properties of 316L stainless steel in the culture medium and then to check the cytotoxicity of the stainless steel in the presence of human mesenchymal stem cells. The characteristics of the stainless steel were evaluated by studying the microstructure of the samples in untreated state and after soaking in minimum essential medium‐alpha (α‐MEM) for 7 days. The results indicated the formation on the surface of the 316L stainless steel of goethite and deposits composed of Ca and P with porous and amorphous structures, which led to the decrease in the elastic modulus and the hardness of the soaked stainless steel as shown by nanoindentation test. Nevertheless, the hardness and the elastic modulus of the steel after soaking were influenced only for a surface depth of approximately 0.1% of the thickness of the sample. The potentiodynamic polarization curves exhibited that the corrosion resistance of the soaked stainless steel was reduced because of the higher passive current density. However, it should be noticed that the breakdown potential of the steel after soaking was slightly higher, leading to a wider range of passivation. In addition, microscopy examination showed the mesenchymal stem cell adhesion on the materials after 9 days of culture.

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