Tissue‐engineering approaches in pancreatic islet transplantation

Pérez-Basterrechea, Marcos; Esteban, Manuel M.; Vega, J.A.; Obaya, Álvaro J.

doi:10.1002/bit.26821

Cited by 19 publications

(19 citation statements)

References 294 publications

(451 reference statements)

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“…Even though IT is minimally invasive, especially compared with whole pancreas transplantation, the different sites used are associated with specific technical complications and different volume capacities. Upcoming bioengineering techniques of stem cells and scaffolds, including the use of auxiliary stem cells such as mesenchymal stem cells, neural crest stem cells, or endothelial progenitor cells, may be used to advance the field of beta cell replacement 53 –57 . However, monitoring possibilities and safety issues make the intrahepatic site inappropriate for this purpose.…”

Section: Discussionmentioning

confidence: 99%

Unsurpassed Intrahepatic Islet Engraftment – the Quest for New Sites for Beta Cell Replacement

2019

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The liver is currently the site of choice for clinical islet transplantation, even though many alternative implantation sites have lately been proposed as more ideal for graft survival. The suggested sites, for example intramuscular space, omentum, bone marrow, and spleen, are sometimes difficult to compare due to differences in animal model, islet isolation procedure, and islet quality. In addition, the variation in transplanted islet mass is vast. The aim of this commentary is to review alternative implantation sites tested experimentally as well as in clinical islet transplantation. Although many sites have been investigated, none have convincingly proved better suited for clinical islet transplantation than intraportal injection to the liver, regardless of whether it is autologous or allogeneic transplantation. However, in order to fully evaluate upcoming bioengineering techniques, such as scaffolds containing insulin-producing cells derived from stem cells, the need of an alternative site has arisen to enable cellular monitoring, which currently cannot be achieved within the liver.

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Section: Discussionmentioning

confidence: 99%

Unsurpassed Intrahepatic Islet Engraftment – the Quest for New Sites for Beta Cell Replacement

2019

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“…Typically, clinical applications seek to repair or stimulate regeneration of degenerating or aging organs by surgical implantation of biocompatible biomaterials or cell-loaded biomaterials with the appropriate cues, as outlined in the principle of the “tissue engineering triad” [ 1 ]. This discipline is considered to hold a critical place in the future of widespread clinical practice, potentially forming a central role in treating an ageing population suffering from cardiovascular [ 2 , 3 ], musculoskeletal, periodontal [ 4 ], and diabetic conditions [ 5 , 6 ]. However, although promising in concept, the reality is that, in implementation, implanted tissue engineered constructs face obstacles that extend beyond the triad, with particular exposure to a stressed oxidative environment that can disrupt successful cellular repopulation and tissue regeneration after transplantation [ 7 ].…”

Section: Oxidative Stress In Tissue Engineering: the Rationale Formentioning

confidence: 99%

Repositioning Natural Antioxidants for Therapeutic Applications in Tissue Engineering

Marrazzo

O’Leary

2020

Bioengineering

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Although a large panel of natural antioxidants demonstrate a protective effect in preventing cellular oxidative stress, their low bioavailability limits therapeutic activity at the targeted injury site. The importance to deliver drug or cells into oxidative microenvironments can be realized with the development of biocompatible redox-modulating materials. The incorporation of antioxidant compounds within implanted biomaterials should be able to retain the antioxidant activity, while also allowing graft survival and tissue recovery. This review summarizes the recent literature reporting the combined role of natural antioxidants with biomaterials. Our review highlights how such functionalization is a promising strategy in tissue engineering to improve the engraftment and promote tissue healing or regeneration.

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“…This system could induce normoglycemia for up to 180 days in a model of human to mice xenotransplantation with minimal immunocyte infiltration on the capsules (Syed et al, 2018). Also linear or star-shaped PEG derivatives are intensively studied for application in layer-by-layer approaches (Ryan et al, 2017; Perez-Basterrechea et al, 2018). Haque et al has built an coating layer with thiol-6-arm-PEG-lipid (SH-6-arm-PEG-lipid) and with gelatin-catechol to provide islets with a substitute for the extracellular matrix of islets and added three other coatings with 6-arm-PEG-SH, 6-arm-PEG-catechol, and linear PEG-SH respectively to provide immunoprotection (Haque et al, 2016).…”

Section: Polymeric Engineering Approaches To Reduce Tissue Responsesmentioning

confidence: 99%

Polymeric Approaches to Reduce Tissue Responses Against Devices Applied for Islet-Cell Encapsulation

Vos

2019

Front. Bioeng. Biotechnol.

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Immunoisolation of pancreatic islets is a technology in which islets are encapsulated in semipermeable but immunoprotective polymeric membranes. The technology allows for successful transplantation of insulin-producing cells in the absence of immunosuppression. Different approaches of immunoisolation are currently under development. These approaches involve intravascular devices that are connected to the bloodstream and extravascular devices that can be distinguished in micro- and macrocapsules and are usually implanted in the peritoneal cavity or under the skin. The technology has been subject of intense fundamental research in the past decade. It has co-evolved with novel replenishable cell sources for cure of diseases such as Type 1 Diabetes Mellitus that need to be protected for the host immune system. Although the devices have shown significant success in animal models and even in human safety studies most technologies still suffer from undesired tissue responses in the host. Here we review the past and current approaches to modulate and reduce tissue responses against extravascular cell-containing micro- and macrocapsules with a focus on rational choices for polymer (combinations). Choices for polymers but also choices for crosslinking agents that induce more stable and biocompatible capsules are discussed. Combining beneficial properties of molecules in diblock polymers or application of these molecules or other anti-biofouling molecules have been reviewed. Emerging are also the principles of polymer brushes that prevent protein and cell-adhesion. Recently also immunomodulating biomaterials that bind to specific immune receptors have entered the field. Several natural and synthetic polymers and even combinations of these polymers have demonstrated significant improvement in outcomes of encapsulated grafts. Adequate polymeric surface properties have been shown to be essential but how the surface should be composed to avoid host responses remains to be identified. Current insight is that optimal biocompatible devices can be created which raises optimism that immunoisolating devices can be created that allows for long term survival of encapsulated replenishable insulin-producing cell sources for treatment of Type 1 Diabetes Mellitus.

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Tissue‐engineering approaches in pancreatic islet transplantation

Cited by 19 publications

References 294 publications

Unsurpassed Intrahepatic Islet Engraftment – the Quest for New Sites for Beta Cell Replacement

Unsurpassed Intrahepatic Islet Engraftment – the Quest for New Sites for Beta Cell Replacement

Repositioning Natural Antioxidants for Therapeutic Applications in Tissue Engineering

Polymeric Approaches to Reduce Tissue Responses Against Devices Applied for Islet-Cell Encapsulation

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