Tissue-Engineering Heart Valves

Maxfield, Mark W.; Cleary, Muriel A.; Breuer, Christopher K.

doi:10.1016/b978-0-12-398358-9.00040-9

Cited by 6 publications

(7 citation statements)

References 98 publications

(140 reference statements)

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“…(a) Schematic view of the heart valves, with the atria removed for better display,; (b) cross‐sectional view a heart valve, showing fibrosa, spongiosa and ventricularis …”

Section: Heart Valve Structure Function and Dysfunctionmentioning

confidence: 99%

“…VICs have five unique subtypes: embryonic, progenitor, quiescent, activated and osteoblastic. Based on mechanical, chemical or hormonal signals or responses, VICs phenotypically change from one subtype to another …”

Section: Heart Valve Structure Function and Dysfunctionmentioning

confidence: 99%

“…It is important to first examine their efficacy and performance by testing on large animals and pre‐clinical models. Also, any risk of bacterial contaminations, rapid degradation and unsatisfactory cell seeding must be avoided . The following section provides detailed information about the design and application of specific successful bioreactors used in TE of heart valves.…”

Section: Bioreactorsmentioning

confidence: 99%

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Bioreactors for heart valve tissue engineering: a review

Amrollahi

Tayebi

2015

J of Chemical Tech & Biotech

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Bioreactors have great potential in the successful development of tissue-engineered heart valve replacements, both at the research stage and in commercial platforms. Their ability to mimick the chemical and physiological conditions of the body has allowed researchers to study in vitro cellular responses, and this has helped in the fabrication of better and more efficient tissues in vivo. Use of different bioreactors, such as, rotating, dynamic flexure, cyclic stretch and pulsatile bioreactors, in tissue engineering of heart valves has been widely investigated. However, this research is still at its early stage, and many critical issues need to be resolved to make tissue engineered heart valves sufficiently reliable for clinical applications. In the following article, after a brief introduction to the structure and role of heart valves, the efforts of tissue engineers in designing heart valves using different bioreactors is described.

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“…(a) Schematic view of the heart valves, with the atria removed for better display,; (b) cross‐sectional view a heart valve, showing fibrosa, spongiosa and ventricularis …”

Section: Heart Valve Structure Function and Dysfunctionmentioning

confidence: 99%

Section: Heart Valve Structure Function and Dysfunctionmentioning

confidence: 99%

Section: Bioreactorsmentioning

confidence: 99%

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Bioreactors for heart valve tissue engineering: a review

Amrollahi

Tayebi

2015

J of Chemical Tech & Biotech

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“…4,5 While mechanical heart valves have long-term durability, patients with these implants must be prescribed anticoagulation medication to prevent valve-related thrombosis. 6,7 Conversely, bioprosthetic heart valves provide more desirable hemodynamics than mechanical heart valves and are less prone to thrombosis. Unfortunately, the leaflets of bioprosthetic heart valves, which are often made from glutaraldehyde-fixed bovine pericardium or porcine valve leaflets, present risk of calcification and progressive structural deterioration along with time.…”

Section: Introductionmentioning

confidence: 99%

Heart valve tissue‐derived hydrogels: Preparation and characterization of mitral valve chordae, aortic valve, and mitral valve gels

Brazile

McMahan

et al. 2018

J Biomed Mater Res

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“…Aortic valve leaflet is composed of three layers: the ventricularis, spongiosa and fibrosa that are predominantly composed of radially, loose and parallel to the cuspal free edge aligned collagen fibers respectively [22]. The role of collagen fibers is to reduce stresses in the leaflets during cardiac cycle and to provide smoother opening and closing valve [23].…”

Section: Initial Geometrymentioning

confidence: 99%

Aortic Valve Geometry Modeling – Review

Dawidowska

2016

Advances in Materials Science

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The present work is a review of publications covering computer simulation of aortic valve operation and material properties of aortic valve components studies. Particular attention is paid to the anisotropy of material and geometric properties. The methods of geometric models developing by using specified research methods and/or diagnostic imaging devices are presented. The microstructure of the aortic valve is also described and its impact on material properties definition introduced. The various ways of describing the aortic valve leaflet anisotropic properties are mentioned. Often exploited simplifications and their impact on the simulation results is also presented.

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Tissue-Engineering Heart Valves

Cited by 6 publications

References 98 publications

Bioreactors for heart valve tissue engineering: a review

Bioreactors for heart valve tissue engineering: a review

Heart valve tissue‐derived hydrogels: Preparation and characterization of mitral valve chordae, aortic valve, and mitral valve gels

Aortic Valve Geometry Modeling – Review

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