Tissue Engineering of Esophagus

Zhu, Yabin; Zhou, Mi; Hou, Ruixia

doi:10.5772/intechopen.69350

Cited by 2 publications

(1 citation statement)

References 54 publications

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“…Tissue regeneration technologically combines arti cial scaffolds, cell-matrix and growth factors (GFs) to provide double or triple matrix products that can be applied in tissue repair and remodeling. It has been con rmed by Zhu et al that these scaffolds can provide functional esophagus substitution well enough to support the growth of pig esophageal cells such as epithelial, broblast and muscle cells 37 . The effects of growth factors (GFs) on wound healing have been the subject of many studies 9,19,17 .…”

Section: Discussionmentioning

confidence: 97%

Enhancing Esophageal Repair With Bioactive Bilayer Mesh Containing FGF

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et al. 2021

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We aimed to prepare a bioactive and biodegradable bilayer mesh formed by fibroblast growth factor (FGF) loaded gelatin film layer, and poly ε-caprolactone (PCL) film layer, and to investigate its treatment efficacy on esophageal anastomosis. It is envisaged that the bioactive mesh in in vivo model would improve tissue regeneration in rats. The full thickness semicircular defects of 0.5x0.5 cm2 were created in anterior walls of abdominal esophagus. The control group had abdominal esophagus isolated with distal esophageal blunt dissection, and sham group had primer anastomosis. In the test groups, the defects were covered with bilayer polymeric meshes containing FGF (5µg/2 cm²), or not. All rats were sacrificed for histopathology investigation after 7 or 28 days of operation. The groups are coded as FGF(-)-7th d, FGF(+)-7th d, and FGF(+)-28th d, based on their content and operation day. Highest burst pressures were obtained for FGF(+)-7th d, and FGF(+)-28th d groups (p < 0.005) and decreased inflammation grades were observed. Submucosal and muscular collagen deposition scores were markedly increased in these groups compared to sham and FGF(-)-7th d groups having no FGF (p = 0.002, p = 0.001, respectively). It was proved that FGF loaded bioactive bilayer mesh provided effective repair, reinforcement and tissue regeneration of esophageal defects.

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Section: Discussionmentioning

confidence: 97%

Enhancing Esophageal Repair With Bioactive Bilayer Mesh Containing FGF

Cesur

Tanır

Çelepli

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

Enhancing esophageal repair with bioactive bilayer mesh containing FGF

Cesur¹,

Tanır

Çelepli³

et al. 2021

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We aimed to prepare a bioactive and biodegradable bilayer mesh formed by fibroblast growth factor (FGF) loaded gelatin film layer, and poly ε-caprolactone (PCL) film layer, and to investigate its treatment efficacy on esophageal anastomosis. It is envisaged that the bioactive mesh in in vivo model would improve tissue healing in rats. The full thickness semicircular defects of 0.5 × 0.5 cm2 were created in anterior walls of abdominal esophagus. The control group had abdominal esophagus isolated with distal esophageal blunt dissection, and sham group had primary anastomosis. In the test groups, the defects were covered with bilayer polymeric meshes containing FGF (5 μg/2 cm2), or not. All rats were sacrificed for histopathology investigation after 7 or 28 days of operation. The groups are coded as FGF(−)-7th day, FGF(+)-7th day, and FGF(+)-28th day, based on their content and operation day. Highest burst pressures were obtained for FGF(+)-7th day, and FGF(+)-28th day groups (p < 0.005) and decreased inflammation grades were observed. Submucosal and muscular collagen deposition scores were markedly increased in these groups compared to sham and FGF(−)-7th day groups having no FGF (p = 0.002, p = 0.001, respectively). It was proved that FGF loaded bioactive bilayer mesh provided effective repair, reinforcement and tissue healing of esophageal defects.

show abstract

Tissue Engineering of Esophagus

Cited by 2 publications

References 54 publications

Enhancing Esophageal Repair With Bioactive Bilayer Mesh Containing FGF

Enhancing Esophageal Repair With Bioactive Bilayer Mesh Containing FGF

Enhancing esophageal repair with bioactive bilayer mesh containing FGF

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