Tissue Engineering Solutions for Cleft Palates

Moreau, Jennifer L.; Caccamese, John F.; Coletti, Dominick P.; Sauk, John J.; Fisher, John P.

doi:10.1016/j.joms.2007.06.648

Cited by 87 publications

(58 citation statements)

References 63 publications

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“…Successful grafting allows eruption of teeth into the former cleft area and further orthodontic expansion of a typically collapsed maxilla 27) . It is ideally carried out at a developmental age between 9 and 11 years, before eruption of the maxillary canine 26) , to allow the canine to erupt through the grafted site 26) .…”

Section: Discussionmentioning

confidence: 99%

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Effects on bone regeneration when collagen model polypeptides are combined with various sizes of alpha-tricalcium phosphate particles

et al. 2011

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We evaluated the effects on bone formation of combining synthesized collagen model polypeptides consisting of a Pro-Hyp-Gly [poly(PHG)] sequence and alpha-tricalcium phosphate (-TCP) particles with various median sizes (large: 580.8 µm; small: 136.2 µm; or large and small mixed: 499.3 µm) in a skull defect model in mini-pigs. Quantitative image analyses for the volume density (VD) of new bone revealed that the VD in each -TCP group was significantly higher than that in the poly(PHG) control group, with the mixed group showing the highest VD among all the groups at 4 weeks after implantation. Histological assessments revealed that the small -TCP particles were almost completely degraded at 8 weeks. At 12 weeks, all sizes of -TCP particles were completely degraded and remodeling of the lamellar bone was observed. The present findings suggest that particle size may influence the success of bone formation in defects.

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Section: Discussionmentioning

confidence: 99%

“…However, harvesting of an autologous bone graft has several disadvantages. For example, the donor site surgery requires a prolonged operating time for young children and may cause morbidity 27) . The present study investigated a new bone graft material for closure of alveolar cleft defects with poly(PHG) and -TCP particles.…”

Section: Discussionmentioning

confidence: 99%

Effects on bone regeneration when collagen model polypeptides are combined with various sizes of alpha-tricalcium phosphate particles

et al. 2011

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“…This variation in bone formation related to the origin of the bone graft has been attributed to a difference in bony architecture, with a greater fraction of cortical bone in the mesenchymal-derived graft (Zins and Whitacker, 1983;Kusiak et al, 1985;Hardesty and Marsh, 1990;Chen et al, 1994;Pinholt et al, 1994). In future, tissue engineering approaches and osteopromotive substances may offer methods with minimal or no donor site morbidity (Jones et al, 2007;Moreau et al, 2007). Resorption is also dependent on functional loading since a long lasting period without tooth migration into the grafted bone will result in further boneloss, because absence of functional loading leads to disuse atrophy of the graft (Bergland et al, 1986;Schultze-Mosgau et al, 2003;Feichtinger et al, 2006, Ozawa et al, 2007.…”

Section: Discussionmentioning

confidence: 99%

Primary osteoplasty using calvarian bone in patients with cleft lip, alveolus and palate

Eichhorn¹,

Blessmann

Pohlenz

et al. 2009

Journal of Cranio-Maxillofacial Surgery

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“…1 While the outcome of lip and palate repair techniques is commonly reported, the treatment of dentoalveolar clefts has received less attention. Restoration of dentoalveolar continuity is essential for stabilization of the maxillary arch, support of dental roots on either side of the cleft, and ultimate eruption of the permanent lateral incisor and canine teeth.…”

mentioning

confidence: 99%

Presurgical Nasoalveolar Molding and Primary Gingivoperiosteoplasty Reduce the Need for Bone Grafting in Patients with Bilateral Clefts

Dec

Shetye

Davidson

et al. 2013

Journal of Craniofacial Surgery

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Preoperative nasoalveolar molding (NAM) in combination with primary gingivoperiosteoplasty (GPP) reduces the need for secondary alveolar bone grafting by 60% in patients with unilateral cleft lip and palate (CL/P). Herein, we investigate the efficacy of NAM and primary GPP in patients with bilateral CL/P. All patients (n = 38) with bilateral CL/P who underwent NAM and primary GPP from 1988 to 1998 with at least 14 years of follow-up were included in this study. Panoramic and periapical radiographs were used to assess dentoalveolar bone formation. A total of 38 patients were identified with median follow-up of 18 years (range 14-26 years). Of the 27 patients who underwent bilateral GPP, 14 (51%) patients had successful dentoalveolar bone formation bilaterally and 13 (49%) had unilateral bone formation. No patient had a bilateral failure. Of the 11 patients who underwent unilateral GPP, 7 (63%) patients had successful dentoalveolar bone formation. Bilateral successful dentoalveolar bone formation following primary bilateral GPP has a dependent probability of 52% and a conditional probability of 82%.

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Tissue Engineering Solutions for Cleft Palates

Cited by 87 publications

References 63 publications

Effects on bone regeneration when collagen model polypeptides are combined with various sizes of alpha-tricalcium phosphate particles

Effects on bone regeneration when collagen model polypeptides are combined with various sizes of alpha-tricalcium phosphate particles

Primary osteoplasty using calvarian bone in patients with cleft lip, alveolus and palate

Presurgical Nasoalveolar Molding and Primary Gingivoperiosteoplasty Reduce the Need for Bone Grafting in Patients with Bilateral Clefts

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