Tissue engineering using 3D printed nano-bioactive glass loaded with NELL1 gene for repairing alveolar bone defects

In oral biology, tissue engineering aims at regenerating functional tissues through a series of key events that occur during alveolar/periodontal tissue formation and growth, by means of scaffolds that deliver signaling molecules and cells. Due to their excellent physicochemical properties and biomimetic features, nanomaterials are attractive alternatives offering many advantages for stimulating cell growth and promoting tissue regeneration through tissue engineering. The main aim of this article was to review the currently available literature to provide an overview of the different nano-scale scaffolds as key factors of tissue engineering for alveolar bone regeneration procedures. In this narrative review, PubMed, Medline, Scopus and Cochrane electronic databases were searched using key words like “tissue engineering”, “regenerative medicine”, “alveolar bone defects”, “alveolar bone regeneration”, “nanomaterials”, “scaffolds”, “nanospheres” and “nanofibrous scaffolds”. No limitation regarding language, publication date and study design was set. Hand-searching of the reference list of identified articles was also undertaken. The aim of this article was to give a brief introduction to review the role of different nanoscaffolds for bone regeneration and the main focus was set to underline their role for alveolar bone regeneration procedures.

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“…Bioactive glass nanoscaffold was investigated and was reported to be beneficial for formation of new alveolar bone tissue [31].…”

Section: Ceramic Npsmentioning

confidence: 99%

Nanotechnology Scaffolds for Alveolar Bone Regeneration

et al. 2020

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“…It has been shown, also in vivo, that different materials have different effects, either positive or negative, on the non-cell-based regeneration techniques [30] . Similarly, these effects have been found in cellbased regenerative therapies, with promising results from beta-TCP [46,[72][73][74] , hyaluronic acid [75,76] , and nano designed materials [77][78][79] . Paknejad et al .…”

Section: Animal Studiesmentioning

confidence: 71%

Stem cells and periodontal regeneration: present and future

Citterio¹,

Gualini²,

Fierravanti³

et al. 2020

Plast Aesthet Res

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The ultimate goal of periodontal regeneration is to restore the damaged alveolar bone proper, root cementum, and periodontal ligament with collagen fibers inserted into the root surface. The search for new regenerative strategies is a challenging field of periodontal research, and tissue engineering, using stem cells, has recently been shown as a promising approach. This paper aims at reviewing the current available literature on the use of stem cells for the treatment of periodontitis. Up to now, different mesenchymal stem cells (MSCs) have shown potential for periodontal regeneration in animal studies. The most investigated MSCs for periodontal regeneration are bone marrow MSCs (BMMSCs), periodontal ligament stem cells (PDLSCs), and dental pulp stem cells (DPSCs), which have shown very promising results in animal models. Few studies on humans are available but BMMSCs, PDLSCs, and DPSCs have been proven safe and effective. Clinical trials are sparse, but tend to support the efficacy of MSCs for periodontal regeneration. In the future, more human studies will be required to support the use of MSCs in daily clinical practice, especially in order to identify the best protocol to harvest, process, and graft MSCs. Future perspectives include trans-differentiation of somatic cells to generate induced pluripotent stem cells, homing procedures, the use of exogenous stem cells, and 3D-printed scaffolds.

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“…Nanotechnology scaffolds (n-scaffold) is a biodegradable polymer which is beneficial in natural extracellular matrix and nanoscale fibrous structure stimulation (Ferracane and Giannobile, 2014). These provide enormous mechanical strength to monitor the cellular activities in regenerative medicine (Zhang et al, 2018). Distribute cells with micro ecosystems, enhance and regulate the capability of cell-based tissue engineering majorly functioning on DDS (drug delivery system) (Ebrahimi et al, 2019).…”

Section: Prominent Role Of Nanoscaffolds In Covid-19mentioning

confidence: 99%

Feasibility of nano-scaffold for Covid-19 infected lung tissue regeneration: A review

Jeevika¹,

Sobiya²,

Indhumathi³

et al. 2021

Asian J Pharm Pharmacol

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In December 2019, a cluster of cases of pneumonia of unknown origin was identified in Wuhan, China which was named as SARS-CoV-2 by the International Committee on Taxonomy of Viruses. The Covid-19 attacks the respiratory system of the infected people leading to its severe damage by eliciting a vigorous immune response by our body. The disease has spread worldwide and affects human health. Covid-19, a newly reported virus is 96% similar to bat CoV. Upon inhalation, the virus enters the respiratory region by unlocking ACE2 protein. Type 2 alveolar cell leading to collapse of alveolus which leads to fluid accumulation, it causes ARDS, SIRS, multi organ failure which cause fatal consequences. In this review, the scope of nanoscaffold in the Covid-19 infected lung tissue regeneration was discussed. Tissue engineering and nanotechnology can help in formation of tissue and guide cellular activities. Damaged tissue can be regenerated by nanoscaffolds that have potential to be risk-free, antiviral and also biological therapeutics. Scaffolds provide intra and extracellular cell contact in regenerative medicine and can provide mechanical strength, oxygen and nutrients for cell metabolism, cell adhesion, and progressive maturation and remove metabolic waste products. It also has some limitations like short circulation half-life of bioactive molecules,inadequate extrinsic factors, variable toxicity, poor regulation and degradation rate. These nanoscaffolds for lung tissue damage due to Covid-19 improve adsorption of ECM protein, new tissue formation, and enhance biological regulation of cell behavior for regeneration and help to recover from lung damage.

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Tissue engineering using 3D printed nano-bioactive glass loaded with NELL1 gene for repairing alveolar bone defects

Cited by 40 publications

References 32 publications

Nanotechnology Scaffolds for Alveolar Bone Regeneration

Nanotechnology Scaffolds for Alveolar Bone Regeneration

Stem cells and periodontal regeneration: present and future

Feasibility of nano-scaffold for Covid-19 infected lung tissue regeneration: A review

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