Tissue eosinophilia in oral intraepithelial neoplasia as a probable indicator of invasion

Martinelli-Kläy, C. P.; Lombardi, Tommaso; Mendis, B. R. R. N.; Soares, EG; Salvado, Francisco; Courvoisier, D.; Mauricio, P

doi:10.1111/odi.12789

Cited by 4 publications

(4 citation statements)

References 24 publications

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“…The prognostic value of 172 protein biomarkers was evaluated by immunohistochemistry in 174 studies (Table 2). These markers are classified according to their biological functions, mainly including such functional pathways as EMT and metastasis [59][60][61][62][63][64][65][66][67][68][69][70][71], inflammation and immunity [72][73][74][75][76][77][78][79][80][81][82][83][84], antioxidant [85,86], angiogenesis [87][88][89][90][91][92][93][94][95][96][97][98][99], cell proliferation, migration and invasion [100][101][102][103][104]…”

Section: Tissue-based Prognostic Biomarkersmentioning

confidence: 99%

Research Progress in Prognostic Factors and Biomarkers of Ovarian Cancer

Liu¹,

Wu²,

Wang³

2021

J. Cancer

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Ovarian cancer is a serious threat to women's health; its early diagnosis rate is low and prone to metastasis and recurrence. The current conventional treatment for ovarian cancer is a combination of platinum and paclitaxel chemotherapy based on surgery. The recurrence and progression of ovarian cancer with poor prognosis is a major challenge in treatment. With rapid advances in technology, understanding of the molecular pathways involved in ovarian cancer recurrence and progression has increased, biomarker-guided treatment options can greatly improve the prognosis of patients. This review systematically discusses and summarizes existing and new information on prognostic factors and biomarkers of ovarian cancer, which is expected to improve the clinical management of patients and lead to effective personalized treatment.

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Section: Tissue-based Prognostic Biomarkersmentioning

confidence: 99%

Research Progress in Prognostic Factors and Biomarkers of Ovarian Cancer

Liu¹,

Wu²,

Wang³

2021

J. Cancer

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“…The predominant findings from these studies indicate that a finding of higher eosinophil infiltration in pre-malignant lesions should prompt a detailed investigation to rule out the invasion. Researchers have also suggested that TEC may be used as an adjunct tool in cases of suspected malignant transformation in oral leukoplakia with dysplastic changes [68,69,71]. Furthermore, an interesting study by Reddy et al revealed that, among 30 cases of oral submucosal fibrosis, 57% exhibited peripheral blood eosinophilia [106].…”

Section: Discussionmentioning

confidence: 99%

“…Supporting this theory, tumour-associated tissue eosinophilia (TATE) and tumour-associated blood eosinophilia (TABE) were identified in one study to be independent prognostic markers for premalignant and malignant OSCC, with elevated tissue eosinophils correlating with a favourable pre-malignancy prognosis, i.e., leukoplakia followed by dysplasia, respectively, while TABE was associated with poor prognosis [70]. Moreover, eosinophils may be considered as an indicator of invasion in oral intraepithelial neoplasia (OIN), and their presence may assist in cases of difficult diagnosis [71]. ↑ TABE is a poor prognosis in high-grade OSCC.…”

Section: Role Of Eosinophils In Oral Precancerous Lesionsmentioning

confidence: 99%

Eosinophils in Oral Disease: A Narrative Review

Al-Azzawi,

Paolini,

Cirillo

et al. 2024

IJMS

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The prevalence of diseases characterised by eosinophilia is on the rise, emphasising the importance of understanding the role of eosinophils in these conditions. Eosinophils are a subset of granulocytes that contribute to the body’s defence against bacterial, viral, and parasitic infections, but they are also implicated in haemostatic processes, including immunoregulation and allergic reactions. They contain cytoplasmic granules which can be selectively mobilised and secrete specific proteins, including chemokines, cytokines, enzymes, extracellular matrix, and growth factors. There are multiple biological and emerging functions of these specialised immune cells, including cancer surveillance, tissue remodelling and development. Several oral diseases, including oral cancer, are associated with either tissue or blood eosinophilia; however, their exact mechanism of action in the pathogenesis of these diseases remains unclear. This review presents a comprehensive synopsis of the most recent literature for both clinicians and scientists in relation to eosinophils and oral diseases and reveals a significant knowledge gap in this area of research.

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“…Another drawback was that the authors described the eosinophils as mononuclear cells with eosinophilic granular cytoplasm (10). In addition to other studies describing quantification of eosinophils in OSCC that was also limited by the subjective counting of the cells (27)(28)(29)(30).The current work provides a digital non subjective method of quantification and confirms that the auto-fluorescent cells are bi-nucleated with granular cytoplasm, that was confirmed on the H&E stained serial section as bi-nucleated cells with granular eosinophilic cytoplasm.…”

Section: Discussionmentioning

confidence: 99%

A Method for Digital Quantification of Eosinophils Infiltrate in Oral Squamous Cell Carcinoma

Younis

2020

Alexandria Dental Journal

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INTRODUCTION:The recent advances in tumor immunotherapy triggered more attention towards analysis of tumor inflammation. Oral squamous cell carcinoma (OSCC) is malignancy that can be therapeutically challenging and resistant to treatment. Further investigation of the inflammatory profile in OSCC can enhance our understanding of the disease and hence patient response to immunotherapy. Eosinophils are suggested to play a significant role in tumor progression and have been described to be associated with advanced stage malignancies of several tumor subtypes. OBJECTIVE: Here we wanted to assess a methodology to quantitatively measure eosinophils infiltrate in OSCC. MATERIAL AND METHODS: Eosinophils infiltrate was analyzed in formalin fixed paraffin embedded tissue (FFPE) microarray cores of 30 oral squamous cell carcinomas (OSCC), and 10 normal oral epithelium controls. Digital analysis using the auto fluorescence of eosinophils accentuated by Alexa Fluor 488 stain, in FFPE tissue sections; we used Cytation 5 machine and Gen 5 software, to digitally quantify the extent of eosinophils infiltrate in OSCC. RESULTS: Out of the inflamed OSCC examined sections with heavy inflammatory infiltrate rich in eosinophils, RBCs, neutrophils and monocytes, eosinophils were readily detected, and digitally quantified after staining with Alexa Fluor 488. The tumor cores showed eosinophils infiltrate in the peri-tumoral stroma of 26 (87%) of the 30 examined OSCC CONCLUSION: This study highlights the importance of assessment of the type and extent of inflammatory cells infiltrate as well as its digital quantification. It provides a novel quantification method of eosinophils that opens avenues to study the correlation between eosinophils infiltrate and tumor prognosis.

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Tissue eosinophilia in oral intraepithelial neoplasia as a probable indicator of invasion

Abstract: Our results suggest that eosinophils can be considered an indicator of invasion in OIN, helping in cases of difficult diagnosis.

Cited by 4 publications

References 24 publications

Research Progress in Prognostic Factors and Biomarkers of Ovarian Cancer

Research Progress in Prognostic Factors and Biomarkers of Ovarian Cancer

Eosinophils in Oral Disease: A Narrative Review

A Method for Digital Quantification of Eosinophils Infiltrate in Oral Squamous Cell Carcinoma

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