Tissue Factor and Atherosclerosis: Not only vessel wall-derived TF, but also platelet-associated TF

Camera, Marina; Brambilla, Marta; Facchinetti, Laura; Canzano, Paola; Spirito, Rita; Rossetti, Laura; Saccu, Claudio; Minno, Matteo Nicola Dario Di; Tremoli, Elena

doi:10.1016/j.thromres.2011.11.028

Cited by 38 publications

(25 citation statements)

References 44 publications

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“…The tissue factor is associated with increased procoagulant activity, and is a major trigger of arterial thrombosis [28] and neointimal formation [29] which lead to cardiovascular disease. Tissue factor level is clearly increased in CKD patients.…”

Section: Discussionmentioning

confidence: 99%

Indoxyl Sulfate Downregulates Mas Receptor via Aryl Hydrocarbon Receptor/Nuclear Factor-kappa B, and Induces Cell Proliferation and Tissue Factor Expression in Vascular Smooth Muscle Cells

Wulaer

Lee

et al. 2016

Nephron

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Background/Aim: Angiotensin converting enzyme-related carboxypeptidase 2/angiotensin (Ang)-(1-7)/Mas receptor axis is protective in the development of chronic kidney disease and cardiovascular disease. This study is aimed at investigating whether indoxyl sulfate (IS) affects Mas receptor expression, cell proliferation and tissue factor expression in vascular smooth muscle cells, and if Ang-(1-7), an activator of Mas receptor, counteracts the IS-induced effects. Methods: IS was administered to normotensive and hypertensive rats. Human aortic smooth muscle cells (HASMCs) were cultured with IS. Results: IS reduced the expression of Mas receptor in the aorta of normotensive and hypertensive rats. IS downregulated the Mas receptor expression in a time- and dose-dependent manner in HASMCs. Knockdown of aryl hydrocarbon receptor (AhR) and nuclear factor-kappa B (NF-κB) inhibited IS-induced downregulation of Mas receptor. Further, IS stimulated cell proliferation and tissue factor expression in HASMCs. Ang-(1-7) attenuated IS-induced cell proliferation and tissue factor expression in HASMCs. Ang-(1-7) suppressed phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2) and NF-κB in HASMCs. Conclusion: IS downregulated the expression of Mas receptor via AhR/NF-κB, and induced cell proliferation and tissue factor expression in HASMCs. Ang-(1-7) inhibited IS-induced cell proliferation and tissue factor expression by suppressing the phosphorylation of ERK1/2 and NF-κB p65.

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Section: Discussionmentioning

confidence: 99%

Indoxyl Sulfate Downregulates Mas Receptor via Aryl Hydrocarbon Receptor/Nuclear Factor-kappa B, and Induces Cell Proliferation and Tissue Factor Expression in Vascular Smooth Muscle Cells

Wulaer

Lee

et al. 2016

Nephron

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“…In blood, TF can be detected in a soluble form, associated to microparticles, or carried by other blood cells, mainly monocytes and platelets [5]. There is a still ongoing debate on whether platelet-associated TF is actually of platelet origin or is uptaken by platelets from the circulation [13].…”

Section: Discussionmentioning

confidence: 99%

“…With respect to coagulation receptors, several studies have demonstrated the presence of tissue factor (TF) on platelet surface [5]. TF, a membrane glycoprotein, is a high-affinity receptor for the plasma coagulation factor VII.…”

Section: Introductionmentioning

confidence: 99%

Tissue Factor Expression on Platelet Surface during Preparation and Storage of Platelet Concentrates

Vignoli

Giaccherini²,

Marchetti³

et al. 2013

Transfus Med Hemother

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Background: Tissue factor (TF), the main activator of blood coagulation, is expressed on platelet surface and, together with procoagulant phospholipids, contributes to the global coagulation potential of these blood components. The present study evaluated, for the first time, the expression of TF on platelet surface during preparation and storage of platelet concentrates (PC) for transfusional use. Methods: Platelet TF was measured by flow cytometry in healthy donor whole blood (WB) and in pooled buffy-coat-derived PC on the day of preparation and up to 4 days of storage in parallel with classical markers of platelet activation, i.e., fibrinogen, P-selectin, and glycoprotein GPIIb. Data were analyzed according to donor age and blood ABO group. Results: TF was detected on whole blood platelets and was found highest in O donors. Compared to whole blood, platelet surface TF was higher upon PC preparation and further increased during storage. The rise in TF levels positively correlated with the elevations of the other platelet markers. Conclusions: Our findings show that platelet surface TF is maintained in PC obtained by the pooled buffy coat method. Further studies are warranted to investigate a possible correlation between TF levels and the hemostatic response of the platelet transfusion recipient.

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“…Upon disruption of the vessel wall or at the sites of activated or damaged endothelium (atherosclerotic plaque), rapid and complex interactions occur between platelets, vascular cells and the coagulation system (Camera et al, 2012;Harker and Fuster, 1986;Pamukcu et al, 2011a;Dutta-Roy et al, 1986). Increased platelet aggregation is achieved by a variety of mechanisms: assembly, increasing expression of aggregating and adhesive receptors, and secretion (Kroll and Schafer, 1989).…”

Section: Human Platelets and Vascular Homeostasismentioning

confidence: 99%

Authorised EU health claims for water-soluble tomato concentrate (WSTC)

Duttaroy

2014

Foods, Nutrients and Food Ingredients With Authorised EU Health Claims

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Tissue Factor and Atherosclerosis: Not only vessel wall-derived TF, but also platelet-associated TF

Cited by 38 publications

References 44 publications

Indoxyl Sulfate Downregulates Mas Receptor via Aryl Hydrocarbon Receptor/Nuclear Factor-kappa B, and Induces Cell Proliferation and Tissue Factor Expression in Vascular Smooth Muscle Cells

Indoxyl Sulfate Downregulates Mas Receptor via Aryl Hydrocarbon Receptor/Nuclear Factor-kappa B, and Induces Cell Proliferation and Tissue Factor Expression in Vascular Smooth Muscle Cells

Tissue Factor Expression on Platelet Surface during Preparation and Storage of Platelet Concentrates

Authorised EU health claims for water-soluble tomato concentrate (WSTC)

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