Tissue factor pathway inhibitor in infants and children

Weissbach, G; Harenberg, Job; Wendisch, J.; Pargac, Nils; Thomas, Kathy

doi:10.1016/0049-3848(94)90045-0

Cited by 22 publications

(9 citation statements)

References 16 publications

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“…Its secretion is reduced in ESLD but increased in states of infection and is variable in malignancies. Heparin binds to TFPI and increases its endogenous antithrombotic action by inhibiting Xa by 2‐4 times and thrombin . Heparin is the ideal agent due to the short half‐life (90 minutes) and the easy titration.…”

Section: Discussionmentioning

confidence: 99%

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Perioperative anticoagulation practices for pediatric liver transplantation

Voulgarelis

Vitola

Lerret

et al. 2018

Pediatric Transplantation

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Despite continued advancements in perioperative care for pediatric liver transplant (LT), graft-threatening vascular occlusion events including hepatic artery thrombosis (HAT) and portal vein thrombosis (PVT) remain a source of significant morbidity and mortality. Perioperative anticoagulation is commonly used for the prevention of HAT and PVT, but evidence-based guidelines are lacking. The goals of this survey were to determine the frequency of use of an anticoagulation protocol and to describe variation in anticoagulation practices among pediatric LT centers. The study consisted of an online survey distributed to members of SPLIT. The survey focused on institutional anticoagulation practices employed to reduce the incidence of graft and life-threatening vascular occlusion events. Responses were received from 31 of 39 SPLIT centers. All respondents report using anticoagulation after pediatric LT, and approximately 90% have institutional anticoagulation protocols. Subgroup analysis of high volume pediatric LT centers revealed similar variability in anticoagulation patterns. All participating SPLIT centers reported the use of post-transplant anticoagulation and nearly all use a protocol. However, there is marked variability in the type and dose of anticoagulation as well as the timing of initiation and duration of therapy across centers.

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Section: Discussionmentioning

confidence: 99%

“…Heparin binds to TFPI and increases its endogenous antithrombotic action by inhibiting Xa by 2-4 times and thrombin. [6][7][8][9] Heparin is the ideal agent due to the short half-life (90 minutes) and the easy titration. It is monitored using PTT or ACT at the bedside, and if bleeding occurs, it can be stopped or reversed effectively.…”

Section: Heparinmentioning

confidence: 99%

Perioperative anticoagulation practices for pediatric liver transplantation

Voulgarelis

Vitola

Lerret

et al. 2018

Pediatric Transplantation

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“…Plasma concentrations of TFPI in fetuses and neonates at birth are decreased by 20% compared with adults. 32 The development of TFPI plasma levels beyond the neonatal period is unknown.…”

Section: Developmental Aspectsmentioning

confidence: 99%

Developmental Hemostasis: Pro- and Anticoagulant Systems during Childhood

Kuhle

Male²,

Mitchell³

2003

Semin Thromb Hemost

129

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An understanding of developmental hemostasis is pivotal for optimal prevention, diagnosis, and treatment of hemostatic problems during childhood. The development of microassays in the early 1980s enabled researchers to delineate age-dependent features of the coagulation system and to establish reference ranges for healthy children of all age groups, from premature infants to adolescents. Based on the results from these studies, the hemostatic system in the young can be described as evolving, and yet functional, since healthy fetuses, infants, and children do not suffer hemorrhagic nor thromboembolic complications spontaneously or in the presence of minor challenges. Plasma concentrations of most pro- and anticoagulant proteins are decreased throughout childhood but provide an effective hemostatic balance on a lower level compared with adults. The current article describes the development of pro- and anticoagulant systems throughout childhood.

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“…Disseminated intravascular coagulation (DIC) [7,8], a condition associated with severe bleeding tendency, organ failure, and sometimes with a very rapid and severe clinical course, is associated with vascular endothelial cell injury. Plasma TFPI levels have been reported to be within normal range or increased in patients with DIC in different studies [9,10]; they are increased in patients with systemic meningococcal disease [11]. Changes in the plasma TFPI level during the clinical course of DIC and its relationship with the prognosis of patients with DIC are still not clear.…”

Section: Introductionmentioning

confidence: 99%

Increased truncated form of plasma tissue factor pathway inhibitor levels in patients with disseminated intravascular coagulation

Shimura¹,

Wada²,

Nakasaki³

et al. 1999

Am. J. Hematol.

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To evaluate that the relationship between the truncated form of tissue factor pathway inhibitor (TFPI) and the stage of disseminated intravascular coagulation (DIC), we measured the plasma levels of tissue factor (TF) antigen and the intact and truncated forms of TFPI antigens in 41 patients with DIC, 12 with pre-DIC, and 20 with non-DIC. The plasma TF and total TFPI antigen levels were significantly higher in patients with DIC than in non-DIC patients. Plasma levels of intact TFPI antigen in the pre-DIC groups were significantly lower than in the non-DIC and DIC groups. The truncated form of TFPI antigen levels in DIC patients were significantly increased compared with those in non-DIC and pre-DIC patients. The fact that the intact form of TFPI was decreased in pre-DIC patients compared with that in non-DIC patients, suggests that it is consumed in the pre-DIC state and that hypercoagulability occurs in pre-DIC patients. The increased level of the truncated form of TFPI in DIC patients may be attributed to proteolysis of the intact form of TFPI in these patients. The increased level of the truncated form of TFPI may be a useful index for the diagnosis of DIC.

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Tissue factor pathway inhibitor in infants and children

Cited by 22 publications

References 16 publications

Perioperative anticoagulation practices for pediatric liver transplantation

Perioperative anticoagulation practices for pediatric liver transplantation

Developmental Hemostasis: Pro- and Anticoagulant Systems during Childhood

Increased truncated form of plasma tissue factor pathway inhibitor levels in patients with disseminated intravascular coagulation

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