Tissue Fibrinolytic Activity in Obesity

Abstract

Summary The fibrinolytic activity of adipose tissue from seven obese and seven lean subjects was studied by incubating biopsy samples on fibrin plates. The obese subjects had normal tissue fibrinolytic activity despite markedly depressed spontaneous blood fibrinolytic activity. There was no correlation between blood and tissue plasminogen activator levels. The tissue activator was associated with the blood vessels and supportive elements of the adipose samples and was not inhibited by the presence of fat cells.

Platelet adhesiveness, coagulation, and fibrinolytic activity in obesity

“…In spite of the low fibrinolytic activity the obese subjects had a normal level of fibrin degradation products, suggesting a normal mechanism for the removal of fibrin deposits. Relevant to this finding are the observations of Grace and Goldrick (1969) that tissue activation levels are normal in obese persons.…”