Tissue Hypoxia and the Production of Erythropoietin

Pagel, Horst; Jelkmann, Wolfgang; Weiß, Ch.

doi:10.1007/978-3-642-83745-6_5

Cited by 1 publication

(1 citation statement)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is postulated that an oxygen sensor is localized in the kidneys and the liver [1,3]. The hypoxic stimulus induces the synthesis of erythropoietin (EPO) in both organs [5]. In the first and second trimester the main production site is the liver, later the kidneys.…”

Section: Introductionmentioning

confidence: 99%

Biochemical monitoring of fetal distress with serum-immunoreactive erythropoietin

Fahnenstich¹,

Dame²,

Alléra³

et al. 1996

Jpme

View full text Add to dashboard Cite

The ability of parameters like umbilical arterial pH and Apgar score to predict and/or to reflect fetal distress are limited. It is known that erythropoietin (EPO) increases when partial pressure of oxygen is insufficient for metabolic demand. Therefore we studied the levels of EPO in the cord blood of stressed neonates (n = 75). In addition, reference values for EPO were established in a group of healthy term infants (n = 54) (mean +/- SD: 20.02 +/- [mU/ml]) and in premature infants (n = 77) according to gestational age. A significant increase in EPO concentrations was found in the stressed group: 153.4 +/- 418.8 [mU/ml], p < 0.003 (n = 27) in acute stress; and 102.6 +/- 127.1 [mU/ml], p < 0.002 (n = 48) in chronic stress. However parameters like hemoglobin, hematocrit, umbilical arterial pH and Apgar-score did not correlate with EPO values. A sensitivity of 59% and a specificity of 92% was calculated. We conclude that serum EPO concentrations are capable of detecting acute and chronic stress and could be useful as a screening method. In part EPO concentrations also allow us to grade stress in pregnancies that are complicated by diseases like preeclampsia.

show abstract

Section: Introductionmentioning

confidence: 99%