Tissue immunostaining for factor XIIIa in dermal dendrocytes of pityriasis alba skin lesions

Carneiro, Francisca Regina Oliveira; Amaral, Gabriela Borborema do; Mendes, Maiana Darwich; Quaresma, Juarez Antônio Simões

doi:10.1590/abd1806-4841.20142201

Cited by 7 publications

(6 citation statements)

References 11 publications

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“…The 23 and elevation of IgE production in infections caused by helminths. 12 The mean level of IgE was much higher in PA patients than Antiparasitic therapy resulted in a decrease of IgE levels in all cases, but a significant reduction was only detected in PA patients with hymenolepiasis.…”

Section: Discussionmentioning

confidence: 99%

“…We analysed the level of total serum IgE in PA patients and control individuals, taking into consideration the similarity of HP histology in PA patients and features of atopic dermatitis23 and elevation of IgE production in infections caused by helminths 12. We analysed the level of total serum IgE in PA patients and control individuals, taking into consideration the similarity of HP histology in PA patients and features of atopic dermatitis23 and elevation of IgE production in infections caused by helminths 12.…”

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confidence: 99%

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Pityriasis alba: Possible associations with intestinal helminths and pathogenic protozoa

Toychiev¹,

Mirzoeva

Davis³

et al. 2019

Int J Clin Pract

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Summary Background The aetiology of pityriasis alba (PA) remains uncertain, and children are at risk for PA and intestinal parasites. Aim To determine the prevalence of intestinal parasites in PA patients and to evaluate their possible role in PA pathogenesis. Methods Overall, 180 PA patients and 100 healthy individuals were enrolled. Intestinal parasites were diagnosed by triple coproscopy, and the total serum Immunoglobulin E (IgE) levels were determined by ELISA. PA patients with intestinal parasites were treated with conventional antiparasitic drugs. Patient response to antiparasitic therapy was evaluated after 6 weeks. Results The prevalence of intestinal parasites in PA patients and controls was 60 ± 3.6% and 32 ± 4.6%, respectively (P < .0001). Regardless of the parasite species among the PA patients and control individuals, the total IgE levels were significantly higher in PA patients (P ≤ .05). The highest values of IgE were found in PA patients with Hymenolepis nana (641.7 ± 46.3 IU/mL). The total IgE level in PA patients with parasites decreased after antiparasitic therapy, but the reduction was only significant in patients with H. nana (P < .05). Complete disappearance of hypopigmented patches was observed after the elimination of H. nana, Giardia lamblia and Enterobius vermicularis in 65 ± 10.6%, 48.7 ± 8.0% and 33.3 ± 8.2% of cases, respectively. In total, a positive clinical response to antiparasitic therapy was achieved in 60 ± 4.7% of infected PA patients. Conclusion A positive clinical response to antiparasitic therapy indicates the role of intestinal parasites in PA pathogenesis. Parasitological examination is justified by the recovery of 60 ± 4.7% of infected PA patients after the elimination of intestinal parasites.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Pityriasis alba: Possible associations with intestinal helminths and pathogenic protozoa

Toychiev¹,

Mirzoeva

Davis³

et al. 2019

Int J Clin Pract

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“…An increased number of FXIII-A-positive DCs were also described in pityriasis alba, suggesting that it could mark a subtle inflammation behind the postinflammatory hypopigmentation, but other causes besides FXIII accumulation were not excluded [ 76 ].…”

Section: Application Of Fxiii-a In Dermatopathologymentioning

confidence: 99%

Factor XIII Subunit A in the Skin: Applications in Diagnosis and Treatment

Paragh

Törőcsik

2017

BioMed Research International

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The role of factor XIII subunit A (FXIII-A) is not restricted to hemostasis. FXIII-A is also present intracellularly in several human cells and serves as a diagnostic marker in a wide range of dermatological diseases from inflammatory conditions to malignancies. In this review, we provide a guide on the still controversial interpretation of dermal cell types expressing FXIII-A and assess the previously described mechanisms behind their accumulation under physiological and pathological conditions of the human skin. We summarize the intracellular functions of FXIII-A as well as its possible sources in the extracellular space of the dermis with a focus on its relevance to skin homeostasis and disease pathogenesis. Finally, the potential role of FXIII-A in wound healing, as a field with long-term therapeutic implications, is also discussed.

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“…1,2 However, the disease has not attracted much attention from medical researchers due to its low harm, good prognosis and self-limiting. [4][5][6] The aetiology of PA is not well established. 1,2 In recent years, it has been considered that the disease is a subtype of atopic dermatitis that is related to specific allergic constitutions.…”

Section: Introductionmentioning

confidence: 99%

“…1,4 Some studies have shown that the disease may be related to wind blowing, sun exposure, strong sunlight, soap stimulation, fungi, viruses, intestinal parasite infection, etc. [6][7][8] Likewise, some scholars believe that the onset may be related to individual physiological skin metabolic problems, such as the temporary lack of certain trace elements and vitamins. 2,[8][9][10] In particular, the lack of zinc and calcium will indirectly affect the formation of pigments.…”

Section: Introductionmentioning

confidence: 99%

Analysis of Epidemic Characteristics and Related Pathogenic Factors of 2726 Cases of Pityriasis Alba

Lv¹,

Gao²,

Lan³

et al. 2022

CCID

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To understand the distribution characteristics of onset time, onset age and gender of pityriasis alba (PA) patients in the dermatology clinic of our hospital and to further explore the pathogenesis of the disease to provide a scientific basis for the prevention and treatment of this disease. Patients and Methods: The clinical data of 2726 outpatients with PA diagnosed for the first time from January 2016 to December 2020 were collected and descriptively analyzed. Results:The number of patients with PA was less from January to March. The peak was reached in July and August. The number of cases affected by the COVID-19 epidemic in 2020 was significantly lower than that in previous years. Furthermore, the onset age of the patients ranged from 0 to 64 years old, and the median age of the total population was 7 (3, 13) years old, including 1566 males (57.45%) and 1160 females (42.55%). The ratio of male to female was 1.35:1. The number of male patients before 18 years old was higher than that of female patients, especially in the high paroxysmal age group. Conclusion: PA can be seen all the year round, and the onset peak of the disease is from July to August every year. It occurs frequently at the age of 1 to 14 before puberty. In the season of high incidence of PA, the protection from sun and moisture retention should be strengthened for infants and adolescents.

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Tissue immunostaining for factor XIIIa in dermal dendrocytes of pityriasis alba skin lesions

Cited by 7 publications

References 11 publications

Pityriasis alba: Possible associations with intestinal helminths and pathogenic protozoa

Pityriasis alba: Possible associations with intestinal helminths and pathogenic protozoa

Factor XIII Subunit A in the Skin: Applications in Diagnosis and Treatment

Analysis of Epidemic Characteristics and Related Pathogenic Factors of 2726 Cases of Pityriasis Alba

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