Tissue Inhibitor of Metalloproteinase-1 Concentrations are Attenuated in Peritoneal Fluid and Sera of Women with Endometriosis and Restored in Sera by Gonadotropin-Releasing Hormone Agonist Therapy

Sharpe-Timms, Kathy L.; Keisler, L W; McIntush, Eric W.; Keisler, D.H.

doi:10.1016/s0015-0282(98)00075-2

Cited by 88 publications

(37 citation statements)

References 9 publications

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“…Although the precise cellular mechanisms that link steroid exposure to the disease process of endometriosis are not yet established, steroidal regulation of MMP expression may represent an important biological connection. A number of studies have shown expression of MMPs in ectopic endometrium [19,20] and a decrease in their expression after successful medical therapy [19,21]. We have more directly implicated MMPs in the establishment of endometriosis by showing that progesterone-mediated MMP suppression or therapeutic injections with TIMP-1, a natural MMP inhibitor, can prevent the establishment of ectopic human endometrial lesions in the peritoneum of nude mice [22].…”

Section: Endometrial Remodeling During the Menstrual Cyclementioning

confidence: 99%

Paracrine Regulation of Matrix Metalloproteinase Expression in the Normal Human Endometrium

Osteen

Keller²,

Feltus³

et al. 1999

Gynecol Obstet Invest

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Endometrial expression of matrix metalloproteinase (MMP)-3, MMP-7 and MMP-11 occurs during menstrual breakdown and subsequent estrogen-mediated growth, but not during the secretory phase. These enzymes are suppressed by progesterone treatment. Paracrine factors, including transforming growth factor-β (TGF-β) and retinoic acid, are also critical for MMP regulation in the endometrium. In contrast, inflammatory cytokines such as interleukin-1α may block or interfere with steroid-mediated MMP regulation at ectopic sites of growth. Using in vitro models, our laboratory has investigated the complex interactions between progesterone and locally produced cytokines that may affect MMP expression during the development of endometriosis. Our results indicate that targeting the regulation of MMPs may represent an appropriate therapeutic strategy for the treatment of endometriosis.

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Section: Endometrial Remodeling During the Menstrual Cyclementioning

confidence: 99%

Paracrine Regulation of Matrix Metalloproteinase Expression in the Normal Human Endometrium

Osteen

Keller²,

Feltus³

et al. 1999

Gynecol Obstet Invest

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“…The concentration of the tissue inhibitor of metalloproteinase-1 is decreased [102]. Other proteins in peritoneal fluid with an uncertain role comprise a 32-kD protein [103], glycodelins and CA-125 [32].…”

Section: Physiopathology Of Endometriosismentioning

confidence: 99%

Pathogenesis of Endometriosis: The Role of Peritoneal Fluid

Koninckx

Kennedy

1999

Gynecol Obstet Invest

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Peritoneal fluid is a specific microenvironment. It originates mainly as an ovarian exudation product due to increased vascular permeability, and contains large amounts of macrophages and their secretion products, which include growth factors, cytokines and angiogenic factors. Similarly, within the ovary, there is also a specific microenvironment, best characterised by the follicular milieu with steroid hormone concentrations that are 1,000 times higher than in plasma. Since endometrial cells in peritoneal fluid and superficially implanted cells will be influenced by peritoneal fluid concentrations, any differences found between minimal endometriosis and eutopic endometrium could be the consequence of their different local environments, rather than inherent cellular differences. Superficial endometrial implants may be regulated by factors in peritoneal fluid, while deep endometriosis and cystic ovarian endometriosis may be under the influence of factors in blood and within the ovary, in which case minimal endometriosis may be physiologic only, while deep endometriosis and cystic ovarian endometriosis, both associated with pelvic pain and infertility, may be a pathological state. In conclusion, the local endocrine environment, that is, in blood, peritoneal fluid, and within the ovary, should be taken into account to explain the differences between superficial, deep and cystic ovarian endometriosis, together with inherent differences in the endometrial cells of women with and without endometriosis.

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“…В группе животных, получав-ших плацебо, адекватной профилактики спаечного про-цесса достигнуто не было. Позже удалось выявить воз-можные регулируемые а-ГнРГ механизмы, снижающие образование спаек [11]. В модели спаечного процесса у крыс авторы показали, что основой противоспаечного эффекта выступают изменения активности активаторов плазминогена, матриксных металлопротеиназ и их инги-биторов под действием а-ГнРГ.…”

Section: результаты и обсуждениеunclassified

Combination treatment with gonadotropin-releasing hormone agonists in reproductive-aged patients with uterine myoma

Plekhanov¹,

Shishkina²,

Gamolin³

et al. 2016

Ross. vestn. akush.-ginekol.

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Tissue Inhibitor of Metalloproteinase-1 Concentrations are Attenuated in Peritoneal Fluid and Sera of Women with Endometriosis and Restored in Sera by Gonadotropin-Releasing Hormone Agonist Therapy

Cited by 88 publications

References 9 publications

Paracrine Regulation of Matrix Metalloproteinase Expression in the Normal Human Endometrium

Paracrine Regulation of Matrix Metalloproteinase Expression in the Normal Human Endometrium

Pathogenesis of Endometriosis: The Role of Peritoneal Fluid

Combination treatment with gonadotropin-releasing hormone agonists in reproductive-aged patients with uterine myoma

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