Tissue kallikrein and tonin levels in submandibular glands of STZ-induced diabetic rats and the effects of insulin

Diabetes causes morphological changes in human submandibular gland: a morphometric study

“…Most investigations were focused on salivary glands with sialadenosis, namely with a severe grade of atrophy and cell degeneration. On the other hand, experiments on rats with induced diabetes and Nod mice showed that submandibular gland features are still affected or only partly restored when glycemic level was controlled by insulin treatment . Our results show that diabetes causes significant changes in human submandibular gland even when glycemia is well controlled and clinical signs of gland malfunctions are absent.…”

“…In our opinion, the results of Chan et al. and Sabino‐Silva et al. on rat salivary glands might be distorted by the intrinsic effects of streptozotocin or alloxan on cell activities, and those of Caldeira et al.…”

Differential secretion of proteins by rat submandibular acini and granular ducts on graded autonomic nerve stimulations.

“…As a result of studying the secretion of peroxidase derived from acinar cells and rKl derived from granular duct cells the present work has also provided new information that further delineates the dual nature of sympathetic neural activation of these secretory cells in the submandibular gland of the rat. The enzymes were assessed by their enzymatic activity, which closely parallels molecular presence for rK1 (Chan et al 1993). No similar study, however, has been undertaken with respect to peroxidase activity.…”

Protein expression in salivary glands of rats with streptozotocin diabetes

“…1989). Other salivary proteins, such as the kallikrein‐like proteases (Chan et al. 1993), PRPs and PSP (Szczepanski et al.…”

“…Epidermal growth factor protein and mRNA levels are substantially reduced in diabetic mice (Kasayama et al 1989). Other salivary proteins, such as the kallikrein-like proteases (Chan et al 1993), PRPs and PSP (Szczepanski et al 1998), also show modest decreases in diabetes. The levels of salivary peroxidase, however, increase approximately twofold in diabetes (Anderson & Shapiro 1979).…”