Tissue Kallikrein-Kinin Therapy in Hypertension and Organ Damage

Endogenous factors and mechanisms of renoprotection and renal repair

“…70 The kallikrein-kinin system in hypertension and organ damage in the context of its positive impact on processes of oxidative stress, apoptosis, inflammation as well as hypertrophy and fibrosis was recently highlighted in a review by Chao et al 71 ADM has a number of functions, among others regulation of hormone secretion and promotion of angiogenesis, but also vasodilation, and was also shown to counterbalance tubular damage in animal models. 70 The kallikrein-kinin system in hypertension and organ damage in the context of its positive impact on processes of oxidative stress, apoptosis, inflammation as well as hypertrophy and fibrosis was recently highlighted in a review by Chao et al 71 ADM has a number of functions, among others regulation of hormone secretion and promotion of angiogenesis, but also vasodilation, and was also shown to counterbalance tubular damage in animal models.…”

“…Factors with renoprotective potential involved in blood pressure regulation are among others the bradykinin receptor B1 (BDKRB1), kininogen 1 (KNG1) or ADM. BDKRB1 was shown to be upregulated in a rat model of high blood pressure supposed to counterbalance profibrotic stimuli via increase of nitric oxide generation as well as inhibition of TGFB1 expression. 70 The kallikrein-kinin system in hypertension and organ damage in the context of its positive impact on processes of oxidative stress, apoptosis, inflammation as well as hypertrophy and fibrosis was recently highlighted in a review by Chao et al 71 ADM has a number of functions, among others regulation of hormone secretion and promotion of angiogenesis, but also vasodilation, and was also shown to counterbalance tubular damage in animal models. 11 The two neuropeptides adenylate cyclase-activating polypeptide 1 (ADCYAP1) and calcitonin-related polypeptide alpha (CALCA) which were highly ranked in our list of renoprotective factors and linked on the level of protein-protein interactions were shown to have vasodilatory potential.…”

Human tissue kallikrein 1 ameliorates erectile function via modulation of macroautophagy in aged transgenic rats

“…(Chao et al, 2014) Previously, we suggested that human KLK1 (hKLK1) may ameliorate erectile dysfunction by reducing corporal fibrosis and apoptosis via regulation of related signaling pathways (Luan et al, 2016;Cui et al, 2017). KLK1 participates in many physiological or pathophysiological processes by processing low molecular weight kininogen (LMWK) to release the kinin peptide.…”

“…KLK1 participates in many physiological or pathophysiological processes by processing low molecular weight kininogen (LMWK) to release the kinin peptide. (Chao et al, 2014) Previously, we suggested that human KLK1 (hKLK1) may ameliorate erectile dysfunction by reducing corporal fibrosis and apoptosis via regulation of related signaling pathways (Luan et al, 2016;Cui et al, 2017). Liu et al demonstrated that in serum-starved SH-SY5Y cells, cell survival and b-catenin degradation were promoted by KLK1 via increase in autophagy, which was partly induced by a bradykinin B2 receptor-dependent process (Liu et al, 2016a,b).…”

Determinación De Los Niveles Séricos De Ferritina Y Cininógeno en Pacientes Con Prediabetes

“…HK forma parte del Sistema calicreina/cinina (KKS), el cual interviene en una amplia gama de actividades biológicas en las que destaca la reducción de tensión arterial. Estudios recientes han relacionado a la hipertensión arterial con alteraciones en el sistema KKS, sin embargo, el mecanismo molecular de este proceso dismetabólico no se ha descrito completamente (Chao et al, 2014;Papageorgius et al, 2014).…”