Tissue Localization of Tetrodotoxin in the Flatworm Planocera multitentaculata (Platyhelminthes: Polycladida)

Yonezawa, Ryo; Hayashi, Kentaro; Oyama, Hikaru; Yoshitake, Kazutoshi; Sato, Soshi; Senevirathna, Jayan Duminda M.; Smith, Ashley R.; Okabe, Taiki; Suo, Rei; Kinoshita, Shigeharu; Takatani, Tomohiro; Arakawa, Osamu; Asakawa, Shuichi; Itoi, Shiro

doi:10.1007/s10126-024-10332-w

Mar Biotechnol

2024

DOI: 10.1007/s10126-024-10332-w

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Tissue Localization of Tetrodotoxin in the Flatworm Planocera multitentaculata (Platyhelminthes: Polycladida)

Ryo Yonezawa,

Kentaro Hayashi,

Hikaru Oyama

et al.

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2024

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Cited by 2 publications

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Epidermal distribution of tetrodotoxin-rich cells in newly hatched larvae of Takifugu spp.

Inahashi,

Yonezawa,

Hayashi

et al. 2024

Mar Biotechnol

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Pufferfish of the genus Takifugu possess tetrodotoxin (TTX), known as “pufferfish toxin” and it is believed that pufferfish eggs and newly hatched larvae utilize TTX as a defensive substance against predators. However, the mechanism for the placement of TTX to specific cells on the larval body surface during the developmental process remains unknown. In this study, we clarify the distribution and characteristics of TTX-rich cells. We performed whole-mount immunohistochemistry (IHC) using anti-TTX monoclonal antibody on larvae of two pufferfish species, Takifugu rubripes and Takifugu alboplumbeus, just after hatching. This allowed observation of the TTX location and compared it with those of wheat germ agglutinin (WGA)-positive (periodic acid-Schiff (PAS)-positive) cells for mucous cells and IHC using anti-Na+/K+-ATPase (NKA) monoclonal antibody for ionocytes. As a result, uniformly scattered localization of TTX-rich cells was commonly observed in the epidermis of the larvae of the two Takifugu species. TTX-rich cells were WGA-negative (PAS-negative) and structurally distinct from NKA-positive cells, suggesting that TTX-rich cells are unreported small cells unique to pufferfish skin, but not mucous cells nor ionocytes.

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Epidermal distribution of tetrodotoxin-rich cells in newly hatched larvae of Takifugu spp.

Inahashi,

Yonezawa,

Hayashi

et al. 2024

Mar Biotechnol

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First data on tetrodotoxins in Cephalothrix mokievskii (palaeonemertea, nemertea) and possible involvement OF POISONOUS nemerteans in toxification of marine bioresources

Malykin,

Velansky,

Magarlamov

2024

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Tissue Localization of Tetrodotoxin in the Flatworm Planocera multitentaculata (Platyhelminthes: Polycladida)

Cited by 2 publications

References 46 publications

Epidermal distribution of tetrodotoxin-rich cells in newly hatched larvae of Takifugu spp.

Epidermal distribution of tetrodotoxin-rich cells in newly hatched larvae of Takifugu spp.

First data on tetrodotoxins in Cephalothrix mokievskii (palaeonemertea, nemertea) and possible involvement OF POISONOUS nemerteans in toxification of marine bioresources

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