Tissue micro-RNAs associated with colorectal cancer prognosis: a systematic review

Santos, Igor Lopes dos; Penna, Karlla Greick Batista Dias; Carneiro, Megmar Aparecida dos Santos; Libera, Larisse Silva Dalla; Ramos, Jéssica Enocêncio Porto; Saddi, Vera Aparecida

doi:10.1007/s11033-020-06075-1

Cited by 9 publications

(11 citation statements)

References 154 publications

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“…miR-4798-3p presents negative results only among males; however, the mechanisms of interaction of this miRNA with AF are still unknown, and further studies are needed to elucidate these mechanisms. miR-20a-5p has already been reported as a biomarker of other diseases, such as non-small-cell lung cancer, which mainly inhibits neoplastic cell proliferation [ 11 , 30 ]. Therefore, these miRNAs are potential biomarkers, and further studies are required to clarify their roles in the development of AF.…”

Section: Discussionmentioning

confidence: 99%

“…In association with mature miR and other proteins, the Argonaut proteins constitute the RNA-induced silencing complex, which targets specific mRNAs. After binding to mRNAs, GW182/TNRC6 proteins interact with Argonaut proteins and recruit the CCR4-NOT deadenylase complex, which induces the degradation or silencing of mRNAs [ 9 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

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Circulating MicroRNAs as Specific Biomarkers in Atrial Fibrillation: A Meta-Analysis

Menezes

Ferreira

Barbosa

et al. 2023

ncRNA

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Atrial fibrillation (AF) is the most frequently occurring supraventricular arrhythmia. Although microRNAs (miRNAs) have been associated with AF pathogenesis, standard protocols for quantifying and selecting specific miRNAs for clinical use as biomarkers should be optimized. In this study, we evaluated the clinical application of miRNAs as biomarkers for the prognosis and diagnosis of AF. Literature searches were conducted on PubMed, Cochrane Library, and EMBASE. We included prospective or retrospective observational studies that had been published as of 14 February 2022; our main objective was to analyze the relationship between circulating miRNAs and AF. The data were extracted using the descriptors “Atrial fibrillation AND miRNA”, “Atrial fibrillation AND diagnostic AND miRNA”, and “Atrial fibrillation AND prognosis AND miRNA”. No filters were applied for period delimitation, type of publication, or language. Studies using samples isolated from blood plasma and TaqMan and RT-qPCR for detecting and quantifying miRNAs were selected, and those that used atrial tissue samples were excluded. We identified 272 articles and excluded 102 duplicated articles. Two authors independently read the titles and abstracts of 170 out of 272 articles and selected 56 potential articles, 6 of which were selected for final review. Our analysis revealed a significant association between AF and miR-4798 [OR = 1.90 (95% CI 1.45–2.47)], AF and miRNA-133a [2.77 (2.73–2.82)], AF and miRNA-150 [3.77 (1.50–9.46); I2 = 70%], AF and miRNA-21 [2.23 (1.20–4.17); I2 = 99%], AF and hsa-miRNA4443 [2.32 (2.20–2.44)], and AF and miR-20a-5p [3.67 (1.42–9.49)]. The association between miRNAs and AF showed an OR of 2.51 [95% CI 1.99–3.16; I2 = 99%]. Our meta-analysis demonstrated that circulating miRNAs are potential biomarkers of AF, as they exhibit stable expression post–sample collection. In addition to regulating cellular processes, such as proliferation, differentiation, development, and cell death, miRNAs were found to be linked to arrhythmia development.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Circulating MicroRNAs as Specific Biomarkers in Atrial Fibrillation: A Meta-Analysis

Menezes

Ferreira

Barbosa

et al. 2023

ncRNA

Self Cite

View full text Add to dashboard Cite

show abstract

“…miR-20a-5p has already been reported as a biomarker of other diseases, such as non-small cell lung cancer, which mainly inhibits neoplastic cell proliferation [11,30]. Therefore, these miRNAs are potential biomarkers, and further studies are required to clarify their roles in the development of AF.…”

Section: Discussionmentioning

confidence: 99%

“…In association with mature miR and other proteins, the Argonaut proteins constitute the RNA-induced silencing complex, which targets speci c mRNAs. After binding to mRNAs, GW182/TNRC6 proteins interact with Argonaut proteins and recruit the CCR4-NOT deadenylase complex, which induces the degradation or silencing of mRNAs [9][10][11].…”

mentioning

confidence: 99%

Circulating microRNAs as specific biomarkers in atrial fibrillation: A meta-analysis

Menezes

Ferreira

Barbosa

et al. 2022

Preprint

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Background Atrial fibrillation (AF) is the most frequent supraventricular arrhythmia. Although microRNAs (miRNAs) have been associated with AF pathogenesis, standard protocols for quantifying and selecting specific miRNAs for clinical use as biomarkers should be optimized. In this study, we evaluated the clinical application of miRNAs as biomarkers for the prognosis and diagnosis of AF. Methods Literature searches were conducted on PubMed, Cochrane Library, and EMBASE. We included prospective or retrospective observational studies that had been published as of 02/14/2022 with the main objective of analyzing the relationship between circulating miRNAs and AF. Data were extracted using the descriptors "Atrial fibrillation AND miRNA," "Atrial fibrillation AND diagnostic AND miRNA," and "Atrial fibrillation AND prognosis AND miRNA," and no filters were applied for period delimitation, type of publication, or language. Studies using samples isolated from blood plasma and TaqMan and RT-qPCR for detecting and quantifying miRNAs were selected, and those that used atrial tissue samples were excluded. We identified 272 articles and excluded 102 duplicated articles. Two authors independently read the titles and abstracts of 170 articles and selected 56 potential articles, 6 of which were selected for final review. Results Our analysis revealed a significant association between AF and miR-4798 [OR = 1.90 (95% CI 1.45–2.47)], AF and miRNA-133a [2.77 (2.73–2.82)], AF and miRNA-150 [3.77 (1.50–9.46); I² = 70%], AF and miRNA-21 [2.23 (1.20–4.17); I² = 99%], AF and hsa-miRNA4443 [2.32 (2.20–2.44)], and AF and miR-20a-5p [3.67 (1.42–9.49)]. The association between miRNAs and AF showed an OR of 2.51 [95% CI 1.99–3.16; I² = 99%]. Conclusions Our meta-analysis demonstrated that circulating miRNAs are potential biomarkers of AF as they exhibit stable expression post-sample collection. In addition to regulating cellular processes, such as proliferation, differentiation, development, and cell death, miRNAs were found to be linked to arrhythmia development.

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“…MicroRNAs (miRNAs) are small noncoding RNAs 18-25 nucleotides in length that function by regulating target genes. Studies have demonstrated that the differential expression of miRNAs has an important relationship with the occurrence, development and prognosis of CRC (10)(11)(12). LncRNAs act as sponges/competing endogenous RNAs (ceRNAs) to regulate the post-transcriptional regulation of miRNAs and are factors in the etiology of numerous diseases (12).…”

Section: Introductionmentioning

confidence: 99%

LncRNA CDKN2B‑AS1 sponges miR‑28‑5p to regulate proliferation and inhibit apoptosis in colorectal cancer

Zhang²,

Zhang

et al. 2021

Oncol Rep

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Long noncoding RNA (lncRNA) CDKN2Bantisense RNA 1 (AS1) functions as a tumor oncogene in numerous cancers. However, the roles and mechanism of CDKN2B-AS1 in colorectal cancer (CRC) have not been explored. The present study aimed to investigate whether and how CDKN2B-AS1 contributes to CRC progression. The data revealed that CDKN2B-AS1 expression was upregulated in CRC tissues. Loss-of-function assays demonstrated that CDKN2B-AS1 in CRC modulated cell proliferation and apoptosis, which was mediated by cyclin D1, cyclin-dependent kinase (CDK) 4, p-Rb, caspase-9 and caspase-3. Bioinformatics analysis and luciferase reporter assays indicated direct binding of microRNA (miR)-28-5p to CDKN2B-AS1. Moreover, the results herein revealed that the expression of miR-28-5p was negatively correlated with that of CDKN2B-AS1 in CRC tissue. Moreover, CDKN2B-AS1 acted as a miR-28-5p competing endogenous RNA (ceRNA) to target and regulate the expression of URGCP. These findings indicated that CDKN2B-AS1 plays roles in CRC progression, providing a potential therapeutic target or novel diagnostic biomarker for CRC.

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Tissue micro-RNAs associated with colorectal cancer prognosis: a systematic review

Cited by 9 publications

References 154 publications

Circulating MicroRNAs as Specific Biomarkers in Atrial Fibrillation: A Meta-Analysis

Circulating MicroRNAs as Specific Biomarkers in Atrial Fibrillation: A Meta-Analysis

Circulating microRNAs as specific biomarkers in atrial fibrillation: A meta-analysis

LncRNA CDKN2B‑AS1 sponges miR‑28‑5p to regulate proliferation and inhibit apoptosis in colorectal cancer

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