Tissue-nanoengineered hyperbranched polymer based multifunctional hydrogels as flexible “wounped treatment-health monitoring” bioelectronic implant

Luo, Xiaomin; Liu, Ying; Qin, Rong; Ao, Fen; Wang, Xuechuan; Zhang, Huijie; Yang, Min; Liu, Xinhua

doi:10.1016/j.apmt.2022.101576

Cited by 17 publications

(17 citation statements)

References 48 publications

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Section: Application Of Mxene‐based Flexible Sensorsmentioning

confidence: 99%

“…Jin et al. [ 224 ] reported a flexible sensor based on bacterial cellulose (BC)/Ti 3 C 2 T x that can be used for oral disease diagnosis and oral health care (Figure 15c). These studies have demonstrated the promise of MXene flexible sensors for a wide range of applications in medical devices.…”

Section: Application Of Mxene‐based Flexible Sensorsmentioning

confidence: 99%

“…Luo et al [223] compounded chitosan and collagen-forming substrates with conductive MXenes and graphene to form a multifunctional biosensor for the monitoring of injured tissues and also for hemostasis, cell proliferation, and skin wound healing under specific electrical stimulation (Figure 15b). Jin et al [224] reported a flexible sensor based on bacterial cellulose (BC)/Ti 3 C 2 T x that can be used for oral disease diagnosis and oral health care (Figure 15c). These studies have demonstrated the promise of MXene flexible sensors for a wide range of applications in medical devices.…”

Section: Smart Healthcarementioning

confidence: 99%

mentioning

confidence: 99%

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MXene‐Based Flexible Sensors: Materials, Preparation, and Applications

Han

Yan

et al. 2023

Adv Materials Technologies

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The rational design and applications of MXene-based materials have yielded remarkable progress in flexible sensors, including wearable devices, soft robots, and smart medical equipment. The emerging MXene and substrate materials can be precisely engineered to improve the mechanical properties and sensing sensitivity of the sensors, opening up a wider range of application possibilities for MXene-based sensors. Therefore, a systematic and comprehensive review summarizing the progress of MXene-based sensor research based on these backgrounds is necessary. First, we discuss the basic structure of MXene materials and introduce the flexible substrate materials for MXene-based flexible sensors in detail. Then, we also discuss the different preparation methods of MXene-based sensors, describe the classifications, and highlight the applications of MXene-based flexible sensors in various scenarios. Finally, we identify the challenges that need to be overcome to accelerate the development of MXene-based materials in flexible sensing. This review provides a comprehensive and systematic insight into MXene-based flexible sensors and it is expected that this review will contribute to the development of higher performance MXene-based flexible sensors.

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Section: Application Of Mxene‐based Flexible Sensorsmentioning

confidence: 99%

Section: Application Of Mxene‐based Flexible Sensorsmentioning

confidence: 99%

Section: Smart Healthcarementioning

confidence: 99%

mentioning

confidence: 99%

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MXene‐Based Flexible Sensors: Materials, Preparation, and Applications

Han

Yan

et al. 2023

Adv Materials Technologies

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“…Skin damage, especially for full-thickness skin defect, involves large and deep skin tissues (epidermis, dermis, subcutaneous tissue, blood vessels, fibrous tissue, mustard tissue, etc.). 1 In addition, the wound is also susceptible to infection that adversely affects healing. 2 Thus, the healing process is complex and often requires external intervention to promote healing.…”

Section: Introductionmentioning

confidence: 99%

Converting Acellular Dermal Matrix into On-Demand Versatile Skin Scaffolds by a Balanceable Crosslinking Approach for Integrated Infected Wounds Therapy

et al. 2023

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Ideal tissue-engineered skin scaffolds should possess integrated therapeutic effects and multifunctionality, such as broad-spectrum antibacterial properties, adjustable mechanical properties, and bionic structure. Acellular dermal matrix (ADM) has been broadly used in many surgical applications as an alternative treatment to the “gold standard” tissue transplantation. However, insufficient broad-spectrum antibacterial and mechanical properties for therapeutic efficacy limit the practical clinical applications of ADM. Herein, a balanceable crosslinking approach based on oxidized 2-hydroxypropyltrimethyl ammonium chloride chitosan (OHTCC) was developed for converting ADM into on-demand versatile skin scaffolds for integrated infected wounds therapy. Comprehensive experiments show that different oxidation degrees of OHTCC have significative influences on the specific origins of OHTCC-crosslinked ADM scaffolds (OHTCC-ADM). OHTCC with an oxidation degree of about 13% could prosperously balance the physiochemical properties, antibacterial functionality, and cytocompatibility of the OHTCC-ADM scaffolds. Owing to the natural features and comprehensive crosslinking effects, the proposed OHTCC-ADM scaffolds possessed the desirable multifunctional properties, including adjustable mechanical, degradable characteristics, and thermal stability. In vitro/in vivo biostudies indicated that OHTCC-ADM scaffolds own well-pleasing broad-spectrum antibacterial performances and play effectively therapeutic roles in treating infection, inhibiting inflammation, promoting angiogenesis, and promoting collagen deposition to enhance the infected wound healing. This study proposes a facile balanceable crosslinking approach for the design of ADM-based versatile skin scaffolds for integrated infected wounds therapy.

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Recent Advances in Biomacromolecule‐Reinforced 2D Material (2DM) Hydrogels: From Interactions, Synthesis, and Functionalization to Biomedical Applications

Gu,

Cui,

et al. 2024

Adv Funct Materials

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Regenerative biomedicine has emerged as a forefront area in medical research, heralding a new era of therapeutic strategies. This review delineates the integration of 2D materials (2DMs) within the area of biomedical engineering, leveraging their superior physicochemical attributes for enhance biomedical outcomes. The synergistic interaction between biomacromolecules and 2DMs is explored, demonstrating their potential to mitigate the limitations inherent to each while simultaneously augmenting their beneficial properties. In particular, incorporating 2DMs into hydrogels highlights their capability to enhance the mechanical strength of hydrogels, providing a biomimetic scaffold for tissue engineering regeneration and cancer diagnosis and therapy. An overview of the synthetic methodologies are provided for 2DMs, elucidating their interaction dynamics with biomacromolecules. The review primarily concentrates on the applications of biomacromolecule‐reinforced 2DM hydrogels across various biomedical fields, including bone tissue engineering, wound healing, neural tissue engineering, cardiac tissue engineering, as well as in the delivery of drugs and genes, cancer therapy, and biosensing technologies. Finally, the review discusses the existing challenges and future outlook for developing and using biomacromolecule‐reinforced 2DM hydrogels, underlining their transformative potential in regenerative medicine.

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Tissue-nanoengineered hyperbranched polymer based multifunctional hydrogels as flexible “wounped treatment-health monitoring” bioelectronic implant

Cited by 17 publications

References 48 publications

MXene‐Based Flexible Sensors: Materials, Preparation, and Applications

MXene‐Based Flexible Sensors: Materials, Preparation, and Applications

Converting Acellular Dermal Matrix into On-Demand Versatile Skin Scaffolds by a Balanceable Crosslinking Approach for Integrated Infected Wounds Therapy

Recent Advances in Biomacromolecule‐Reinforced 2D Material (2DM) Hydrogels: From Interactions, Synthesis, and Functionalization to Biomedical Applications

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