Tissue oxygen monitoring by photoacoustic lifetime imaging (PALI) and its application to image-guided photodynamic therapy (PDT)

Shao, Qi; Morgounova, Ekaterina; Ashkenazi, Shai

doi:10.1117/12.2080609

Cited by 3 publications

(2 citation statements)

References 6 publications

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“…They have built a multi-modal system integrating ultrasound imaging, regular photoacoustic imaging, as well as PALI (Figure 4b) to map the distribution of oxygen partial pressure in tissue, from which hypoxic areas can be clearly identified [45,46]. Based on these studies, they further developed treatment/imaging modality referred to as PDT-PALI (Figure 4c), which enables real-time feedback of three essential parameters during a PDT therapy: tissue oxygen, light penetration in tumor location, and distribution of photosensitizer [47,48]. Lifetime-based PAT technique by using G2 molecules for blood oxygenation sensing [49,50] and MB loaded polyacrylamide nanoparticles (MB-PAA NPs) for tumor oxygen sensing [51] have also been demonstrated by other groups.…”

Section: Photoacoustic Imaging In Po 2 Measurementmentioning

confidence: 99%

Photoacoustic Imaging in Oxygen Detection

Cao

Qiu

et al. 2017

Applied Sciences

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Oxygen level, including blood oxygen saturation (sO 2 ) and tissue oxygen partial pressure (pO 2 ), are crucial physiological parameters in life science. This paper reviews the importance of these two parameters and the detection methods for them, focusing on the application of photoacoustic imaging in this scenario. sO 2 is traditionally detected with optical spectra-based methods, and has recently been proven uniquely efficient by using photoacoustic methods. pO 2 , on the other hand, is typically detected by PET, MRI, or pure optical approaches, yet with limited spatial resolution, imaging frame rate, or penetration depth. Great potential has also been demonstrated by employing photoacoustic imaging to overcome the existing limitations of the aforementioned techniques.

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Section: Photoacoustic Imaging In Po 2 Measurementmentioning

confidence: 99%

Photoacoustic Imaging in Oxygen Detection

Cao

Qiu

et al. 2017

Applied Sciences

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“…PALI can potentially be applied for imaging guidance or treatment evaluation in photodynamic therapy and radiotherapy of cancers [140]. Recent works have demonstrated PALI using methylene blue [127,141,142], and achieved oxygenation mapping at 15 mm depth with submillimeter spatial resolution [127,140,143]. Another solution to the issue of unknown optical fluence at depths was recently demonstrated in eigenspectral multispectral optoacoustic tomography (eMSOT) [135,144].…”

Section: Functional Patmentioning

confidence: 99%

Listening to tissues with new light: recent technological advances in photoacoustic imaging

Razansky

Yao

2019

J. Opt.

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Photoacoustic tomography (PAT), or optoacoustic tomography, has achieved remarkable progress in the past decade, benefiting from the joint developments in optics, acoustics, chemistry, computing and mathematics. Unlike pure optical or ultrasound imaging, PAT can provide unique optical absorption contrast as well as widely scalable spatial resolution, penetration depth and imaging speed. Moreover, PAT has inherent sensitivity to tissue's functional, molecular, and metabolic state. With these merits, PAT has been applied in a wide range of life science disciplines, and has enabled biomedical research unattainable by other imaging methods. This Review article aims at introducing state-of-the-art PAT technologies and their representative applications. The focus is on recent technological breakthroughs in structural, functional, molecular PAT, including super-resolution imaging, real-time small-animal whole-body imaging, and high-sensitivity functional/molecular imaging. We also discuss the remaining challenges in PAT and envisioned opportunities.

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