Tissue Oxygenation Maps of Diabetic Foot Ulcers: Longitudinal Studies

Fernandez, Cristianne; Kwasinski, Rebecca; Leiva, Kevin; Schutzman, Richard; Robledo, Edwin; Kallis, Penelope; Borda, Luis J.; Perez-Clavijo, Francisco; Kirsner, Robert S.; Godavarty, Anuradha

doi:10.1364/translational.2018.jth3a.6

Cited by 3 publications

(5 citation statements)

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“…Three repeated measurements of diffused reflected data were acquired for each NIR wavelength at each time point along with three repetitions of a calibration image (at each wavelength) acquired using a uniformly diffused sheet. 9,12 The field of view consisted of the DFU and the sur-rounding tissue. The distance between NIROS and the imaged tissue was not kept constant in each subject but was varied based on the location of the wound and/or its size.…”

Section: Data Acquisitionmentioning

confidence: 99%

“…TO in and around the wounds can be measured using various imaging tools, such as hyperspectral imaging, 5,8,9 multispectral imaging, 10 and nearinfrared spectroscopy (NIRS). 11,12 These imaging modalities use wavelengths in the visible and/ or near-infrared (NIR) regions to obtain twodimensional (2D) maps or spectroscopic point measurements of oxy-hemoglobin (HbO), deoxyhemoglobin (HbR), total hemoglobin (HbT), and/or oxygen saturation (StO 2 ). The 2D distribution maps of these hemoglobin-based concentration parameters (HbO, HbR, HbT, and StO 2 ) are quantitatively determined (as percentages) in and around the wound.…”

Section: Introductionmentioning

confidence: 99%

“…Recently, we have developed a handheld NIRSbased near-infrared optical scanner (NIROS) in our laboratory to perform noncontact imaging of wounds as a bedside imaging tool. 8,[12][13][14] The device has demonstrated the ability to longitudinally measure the hemoglobin concentration changes across the treatment period in DFUs 12 as well as venous leg ulcers. 14 While our previous studies have focused on oxygenation changes across weeks of treatment, the current study focuses on discrete imaging at different time points in response to a breath-hold (BH) paradigm to assess the regions of poor blood flow (or differences in oxygen supply).…”

Section: Introductionmentioning

confidence: 99%

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Breath-Hold Paradigm to Assess Variations in Oxygen Flow in Diabetic Foot Ulcers Using a Noncontact Near-Infrared Optical Scanner

Leiva

Mahadevan

Kaile

et al. 2019

Advances in Wound Care

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Objective: Diabetic foot ulcers (DFUs) occur in almost 25% of all patients with diabetes in their lifetime, with oxygen being the key limiting factor in healing. Identifying regions of compromised oxygenated flow can help clinicians cater the wound treatment process, possibly reducing wound healing time. Herein, a handheld, noncontact near-infrared optical scanner (NIROS) was developed and used to measure temporal changes in hemoglobin concentrations in response to a breath-hold (BH) paradigm. Approach: Noncontact imaging studies were carried out on DFU subjects and control subjects in response to a 20-s BH paradigm. Continuous-wave-based multiwavelength diffused reflective signals were acquired to generate effective oxy-hemoglobin, deoxy-hemoglobin, total hemoglobin, and oxygen saturation concentration maps using modified Beer-Lambert's law. Pearson's correlation analysis was carried out to determine variations in oxygen flow from hemoglobin concentration maps and the extent of variation observed in controls versus DFU subjects. Results: Temporal changes in hemoglobin concentration maps were observed in controls and DFU subjects. However, the oxygen flow in response to BH varied within 10% in all controls but significantly varied between wound and background regions in subjects with DFUs. Innovation: A method to assess variations in oxygen supply in and around DFUs was demonstrated using NIROS. This approach has potential to better cater DFU treatment process. Conclusion: Changes in all hemoglobin parameters due to 20 s of BH was observed. Pearson's analysis indicates that oxy-hemoglobin, deoxy-hemoglobin, and oxygen saturation fluctuations are synchronous in controls. In DFUs, changes are asynchronous with blood flow between the wound region and background region being significantly different.

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Section: Data Acquisitionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Breath-Hold Paradigm to Assess Variations in Oxygen Flow in Diabetic Foot Ulcers Using a Noncontact Near-Infrared Optical Scanner

Leiva

Mahadevan

Kaile

et al. 2019

Advances in Wound Care

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“…NIRS uses discrete NIR wavelengths to obtain these tissue oxygenation measurements at discrete point locations via contact in and around the wound [6,7]. More recently an NIR-based optical scanner (NIROS) light was developed [8,9,10,11] to obtain tissue oxygenation maps of the wound region via non-contact imaging (as in HSI and MSI) [10,11,12]. NIROS uses discrete NIR wavelengths unlike HSI and MSI technologies and the device is handheld, low cost, and portable.…”

Section: Introductionmentioning

confidence: 99%

“…NIR optical imaging technology has been used in various applications such as cancer diagnostics, functional brain mapping, and more recently in the area of wound imaging. In the area of wound imaging, both spectroscopic point-based NIR imaging [6,7] and area-based imaging approaches [8,9,10,11,12] have been developed.…”

Section: Introductionmentioning

confidence: 99%

Development and Validation of a Smartphone-Based Near-Infrared Optical Imaging Device to Measure Physiological Changes In-Vivo

Kaile

Godavarty

2019

Micromachines

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Smartphone-based technologies for medical imaging purposes are limited, especially when it involves the measurement of physiological information of the tissues. Herein, a smartphone-based near-infrared (NIR) imaging device was developed to measure physiological changes in tissues across a wide area and without contact. A custom attachment containing multiple multi-wavelength LED light sources (690, 800, and 840 nm; and <4 mW of optical power per LED), source driver, and optical filters and lenses was clipped onto a smartphone that served as the detector during data acquisition. The ability of the device to measure physiological changes was validated via occlusion studies on control subjects. Noise removal techniques using singular value decomposition algorithms effectively removed surface noise and distinctly differentiated the physiological changes in response to occlusion. In the long term, the developed smartphone-based NIR imaging device with capabilities to capture physiological changes will be a great low-cost alternative for clinicians and eventually for patients with chronic ulcers and bed sores, and/or in pre-screening for potential ulcers in diabetic subjects.

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Oxygenation based perfusion assessment of diabetic foot ulcers using a breath-hold paradigm

Leiva

Mahadevan

Lozano

et al. 2019

Optical Biopsy XVII: Toward Real-Time Spectroscopic Imaging and Diagnosis

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Tissue Oxygenation Maps of Diabetic Foot Ulcers: Longitudinal Studies

Cited by 3 publications

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Breath-Hold Paradigm to Assess Variations in Oxygen Flow in Diabetic Foot Ulcers Using a Noncontact Near-Infrared Optical Scanner

Breath-Hold Paradigm to Assess Variations in Oxygen Flow in Diabetic Foot Ulcers Using a Noncontact Near-Infrared Optical Scanner

Development and Validation of a Smartphone-Based Near-Infrared Optical Imaging Device to Measure Physiological Changes In-Vivo

Oxygenation based perfusion assessment of diabetic foot ulcers using a breath-hold paradigm

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