Tissue Perfusion and Oxygenation Related to Wound Healing and Resistance to Infection

Gottrup, Finn

doi:10.1007/978-3-642-79079-9_17

Cited by 4 publications

(3 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Production of collagen, cross-linking and the development of strength in the wound are directly correlated to the partial pressure of oxygen in the tissue (P t O 2 ) dependent as they are on speci c enzymes (5,8,16,19,27). The function of these enzymes is directly related to the amount of oxygen present, for example the hydrolysation of proline and lysine by hydroxylase enzymes (28).…”

Section: Oxygen and Wound Healingmentioning

confidence: 99%

Oxygen, wound healing and the development of Infection. Present status

Gottrup

2002

Eur J Surg

View full text Add to dashboard Cite

Wounds do not heal in tissue that does not bleed and almost always heal in tissue that bleeds extensively. A continuous supply of oxygen to the tissue is vital for the healing process and to resist infection. External factors may decrease the peripheral oxygen supply, but supplementary perioperative oxygen reduces the surgical wound infection rate to half in patients having colorectal resections. Hyperbaric oxygen may be beneficial when the flow and oxygen supply to the healing tissue are compromised by local injury and particularly if anaerobic infection is present. Assessment of perfusion and oxygenation is essential during and after surgery.

show abstract

Section: Oxygen and Wound Healingmentioning

confidence: 99%

Oxygen, wound healing and the development of Infection. Present status

Gottrup

2002

Eur J Surg

View full text Add to dashboard Cite

show abstract

“…Collagen production and development, which influences the strength of the wound, is directly correlated with the partial oxygen pressure P o 2 of the tissue (P t o 2 ) [1, 2, 3]. Synthesis of collagen, cross‐linking, and the resulting wound strength is reliable of the normal function of specific enzymes [1, 2, 3, 4, 5]. The function of these enzymes is directly related to the amount of oxygen present—e.g., hydrolyzation of proline and lysine by hydroxylase enzymes [6].…”

mentioning

confidence: 99%

Oxygen in Wound Healing and Infection

2004

View full text Add to dashboard Cite

It is a fundamental clinical observation that wounds do not heal in tissue that does not bleed, and they almost always heal in tissue that bleeds extensively. Continuous supply of oxygen to the tissue through microcirculation is vital for the healing process and for resistance to infection. Evaluation of tissue perfusion and oxygenation is important in all types of wound patients. Monitoring systems should measure the hemodynamic situation and the ability of the cardiovascular system to deliver an adequate volume of oxygen to meet the metabolic demands of the peripheral tissue. Oxygen therapy is important in relation to both healing and resistance to infections. External factors have been shown to significantly decrease the peripheral oxygen supply, and supplementary perioperative oxygen to reduce the surgical wound infection rate by one- half in patients undergoing colorectal resection. Hyperbaric oxygen therapy may be beneficial in situations where the nutritive flow and oxygen supply to the healing tissue are compromised by local injury, and particularly if anaerobic infection is present. However, the definitive proof for the effect and indications of this therapy in wound healing still has to be established. It can be concluded that adequate delivery of oxygen to the wound tissue is vital for optimal healing and resistance to infection. Assessment of perfusion and oxygenation is essential for the wound patient, as well as the treating personnel. The indication for hyperbaric oxygen treatment still needs to be defined. During wound healing the continuity and function of the damaged tissue are re-established. This is only possible through a restoration of the microcirculation and thereby the nutrition to the tissue. The main component of the nutrition is oxygen, which is critically important for healing a wound by production of granulation tissue and for ensuring resistance against infection. This has been shown experimentally, but recently a short period of supplementary oxygen has been shown to decrease wound complications in clinical practice as well.

show abstract

“…4 Lessened perfusion may be the most important determinant of wound healing and resistance to infection after injury. [5][6][7][8][9][10][11] External fixation (EF) provides initial stabilization with minimal soft tissue insult and allows for monitoring of the skin and soft tissues through the inflammatory phase. 9,12 Currently, surgeons use clinical evaluation of the soft tissue envelope by assessing for skin wrinkling and reepithelialization of fracture blisters to determine readiness for definitive management.…”

Section: Introductionmentioning

confidence: 99%