Tissue polarimetric discrimination analysis of skin and colon histological samples

Ivanov, Deyan; Borisova, Ekaterina; Genova, Tsanislava; Nedelchev, Lian; Nazarova, Dimana

doi:10.1063/1.5091382

Cited by 6 publications

(4 citation statements)

References 14 publications

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“…[19] Tissue polarimetry, for example, is widely used as a diagnostic tool where healthy and tumorous tissue samples modify the initial state of polarization or decrease the initial degree of polarization. [20][21][22][23][24][25][26][27][28] Mueller matrices of the corresponding tissue specimens under examination can give insight of their polarization-depolarization properties. [29] Polarimetric imaging possesses tremendous advantages, in order to localize small, but significant histological alteration within the examined or scanned tissue zone.…”

Section: Introductionmentioning

confidence: 99%

Colon cancer detection by using Poincaré sphere and 2D polarimetric mapping of ex vivo colon samples

Ivanov

Dremin

Bykov

et al. 2020

Journal of Biophotonics

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This work is dedicated to the diagnosis and grading of colon cancer by a combined use of Poincaré sphere and 2D Stokes vector polarimetry mapping approaches. The major challenge consists in exploring the applicability of polarized light for non-invasive screening of the histological abnormalities within the samples of biological tissues. Experimental studies were conducted in ex vivo colon sample, excised after surgical procedure for colon tumour removal of G2-adenocarcinoma lesion. Polarimetric measurements in linear and circular regime were carried via personally developed polarimetric, optical set-up, using supercontinuous fibre laser with irradiation fixed at 635 nm. We apply the Poincaré sphere and two-dimensional Stokes vector scanning approach for screening the corresponding tissue samples. A comparison between linear and circular polarization states is made both for quantitative and qualitative evaluations. It is shown that circular polarization has better diagnostic capabilities than linear polarization, with higher dynamic ranges of the polarimetric parameters and better values of the diagnostic quantities. In addition to the standard polarimetry parameters, utilized as essential diagnostic markers, we apply statistical analysis to obtain more detailed information in frame of the applied diagnostic approach.

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Section: Introductionmentioning

confidence: 99%

Colon cancer detection by using Poincaré sphere and 2D polarimetric mapping of ex vivo colon samples

Ivanov

Dremin

Bykov

et al. 2020

Journal of Biophotonics

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“…Thereafter, the polarimetric diagnosis of tissues became a focus of another cooperation with the Institute of Optical Materials and Technologies, "Acad. J. Malinowski" -Bulgarian Academy of Sciences, yielding several proceedings papers [71][72][73], one of which was recognized with Best Student Paper Award from the SPIE [74]. Further, a memorandum for cooperation between the IE-BAS and the University of Oulu, Finland, was useful to produce other prolific results in the field of tissue polarimetry [75][76][77], where one of the manuscripts was awarded with a Cover Page in the Journal of Biophotonics [75].…”

Section: Polarization-sensitive Optical Techniquesmentioning

confidence: 99%

A review of career devoted to Biophotonics – In memoriam to Ekaterina Borisova (1978–2021)

Genova¹,

Avramov²,

Kolev³

et al. 2021

J-BPE

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Regretfully, because of her sudden demise, Assoc. Prof. Ekaterina Borisova is no longer amongst us. COVID-19 pulled away a brilliant scientist during the peak of her scientific career (see Fig. 1). All authors would like to express deepest condolences and sincere support to her family, friends, relatives and colleagues! We, therefore, rightfully commemorate her dedicated and devoted contribution to biophotonics, her readiness to always support, help, motivate and inspire all her colleagues and collaborators. Fig. 1 Assoc. Prof. Ekaterina Borisova examining samples under microscope.

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“…In cancerous tissue, the cell nuclei are enlarged due to the abnormal growth of cancer, which can be detected by the difference in the DOCP of the normal and tumor tissues. Following these reports, the polarimetry technique for tissue observation using the polarization of light, including CPL, has been extensively studied [23–30]. Recently, the polarimetry technique has been applied for grading colon cancer [31], Alzheimer's disease [32] and early‐stage breast cancer [33].…”

Section: Introductionmentioning

confidence: 99%

Depth estimation of tumor invasion in early gastric cancer using scattering of circularly polarized light: Monte Carlo Simulation study

Nishizawa

Kuchimaru

2022

Journal of Biophotonics

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Quantitative depth estimation of tumor invasion in early gastric cancer by scattering of circularly polarized light is computationally investigated using the Monte Carlo method. Using the optical parameters of the human stomach wall and its carcinoma, the intensity and circular polarization of light scattered from pseudo‐healthy and cancerous tissues were calculated over a wide spectral range. Large differences in the circular polarization with opposite signs, together with the large intensity, are obtained at wavelengths 600 nm and 950 nm. At these two wavelengths, the sampling depth of the biological tissues can be modulated by tuning the detection angle. In bi‐layered pseudo‐tissues with a cancerous layer on a healthy layer and vice versa, the degree of circular polarization of scattered light shows systematic changes depending on the thickness and depth of the cancerous layer, which indicates the feasibility of in vivo quantitative estimation of cancer progression in early gastric cancer.

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Tissue polarimetric discrimination analysis of skin and colon histological samples

Cited by 6 publications

References 14 publications

Colon cancer detection by using Poincaré sphere and 2D polarimetric mapping of ex vivo colon samples

Colon cancer detection by using Poincaré sphere and 2D polarimetric mapping of ex vivo colon samples

A review of career devoted to Biophotonics – In memoriam to Ekaterina Borisova (1978–2021)

Depth estimation of tumor invasion in early gastric cancer using scattering of circularly polarized light: Monte Carlo Simulation study

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