Tissue processing of endoscopic ultrasound-guided fine-needle aspiration specimens from solid pancreatic lesions

Notohara, Kenji; Nakamura, Kaori

doi:10.1007/s10396-023-01387-8

Cited by 3 publications

(1 citation statement)

References 79 publications

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“… 10 Moreover, various methods have been developed for processing these pathological specimens, as processing can improve diagnostic performance. 11 …”

Section: Introductionmentioning

confidence: 99%

Updated techniques and evidence for endoscopic ultrasound‐guided tissue acquisition from solid pancreatic lesions

Itonaga,

Ashida,

Kitano

2024

DEN Open

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Endoscopic ultrasound‐guided tissue acquisition (EUS‐TA), including fine‐needle aspiration (EUS‐FNA) and fine‐needle biopsy (EUS‐FNB), has revolutionized specimen collection from intra‐abdominal organs, especially the pancreas. Advances in personalized medicine and more precise treatment have increased demands to collect specimens with higher cell counts, while preserving tissue structure, leading to the development of EUS‐FNB needles. EUS‐FNB has generally replaced EUS‐FNA as the procedure of choice for EUS‐TA of pancreatic cancer. Various techniques have been tested for their ability to enhance the diagnostic performance of EUS‐TA, including multiple methods of sampling at the time of puncture, on‐site specimen evaluation, and specimen processing. In addition, advances in next‐generation sequencing have made comprehensive genomic profiling of EUS‐TA samples feasible in routine clinical practice. The present review describes updates in EUS‐TA sampling techniques of pancreatic lesions, as well as methods for their evaluation.

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“… 10 Moreover, various methods have been developed for processing these pathological specimens, as processing can improve diagnostic performance. 11 …”

Section: Introductionmentioning

confidence: 99%

Updated techniques and evidence for endoscopic ultrasound‐guided tissue acquisition from solid pancreatic lesions

Itonaga,

Ashida,

Kitano

2024

DEN Open

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Endoscopic Ultrasound-Guided Through-the-Needle Biopsy: A Narrative Review of the Technique and Its Emerging Role in Pancreatic Cyst Diagnosis

Vilas-Boas,

Ribeiro,

Macedo

et al. 2024

Diagnostics

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Pancreatic cystic lesions (PCLs) pose a diagnostic challenge due to their increasing incidence and the limitations of cross-sectional imaging and endoscopic-ultrasound-guided fine-needle aspiration (EUS-FNA). EUS-guided through the needle biopsy (EUS-TTNB) has emerged as a promising tool for improving the accuracy of cyst type determination and neoplastic risk stratification. EUS-TTNB demonstrates superior diagnostic performance over EUS-FNA, providing critical preoperative information that can significantly influence patient management and reduce unnecessary surgeries. However, the procedure has risks, with an overall adverse event rate of approximately 9%. Preventive measures and further prospective studies are essential to optimize its safety and efficacy. This review highlights the potential of EUS-TTNB to enhance the diagnostic and management approaches for patients with PCLs. It examines the current state of EUS-TTNB, including available devices, indications, procedural techniques, specimen handling, diagnostic yield, clinical impact, and associated adverse events.

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Role of Liquid-Based Cytology in the Endoscopic Diagnosis of Pancreatic Ductal Adenocarcinoma

Kitagawa,

Mitoro,

Suzuki

et al. 2024

JCM

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Recently, endoscopic ultrasound-guided tissue acquisition (EUS-TA) has been widely used to diagnose pancreatic ductal adenocarcinoma (PDAC). The histological examination of core tissues acquired using novel biopsy needles is the primary diagnostic approach for patients with PDAC. However, in patients with early-stage PDAC, such as Stages 0 and I, EUS-TA can be challenging, and its diagnostic accuracy may be limited. This presents a clinical dilemma: The earlier that clinicians attempt to accurately diagnose PDAC, the more difficult it becomes to do so using EUS-TA. Liquid-based cytology (LBC) is a technique for preparing pathological specimens from liquefied cytology specimens by placing the collected material in a special fixative preservative fluid. LBC offers advantages, such as specimen optimization with reduced blood interference, a high cell-collection rate, and the simplicity of the procedure in the endoscopy room. The use of LBC may improve diagnostic accuracy, particularly for early-stage PDAC. Therefore, we emphasize that cytology remains a valuable tool for the endoscopic diagnosis of PDAC. In this review, we discuss the role of LBC in the endoscopic diagnosis of PDAC.

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Tissue processing of endoscopic ultrasound-guided fine-needle aspiration specimens from solid pancreatic lesions

Cited by 3 publications

References 79 publications

Updated techniques and evidence for endoscopic ultrasound‐guided tissue acquisition from solid pancreatic lesions

Updated techniques and evidence for endoscopic ultrasound‐guided tissue acquisition from solid pancreatic lesions

Endoscopic Ultrasound-Guided Through-the-Needle Biopsy: A Narrative Review of the Technique and Its Emerging Role in Pancreatic Cyst Diagnosis

Role of Liquid-Based Cytology in the Endoscopic Diagnosis of Pancreatic Ductal Adenocarcinoma

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