Tissue protein turnover in animals treated with the mixed β-agonist metaproterenol: Influence of dose, route and pattern of administration

Effect of sympathetic denervation on the rate of protein synthesis in rat skeletal muscle

“…Experiments have been carried out in several species to find out whether an increased rate of protein synthesis contributes to the muscle hypertrophy induced by ␤ 2 -agonist administration (4,19). The results obtained in vivo have been conflicting because of differences in the technique used for measurement of protein synthesis and in the experimental design, such as dose, route of drug administration, and timing of measurements (26). The finding in some experiments that muscle protein synthesis was not affected in clenbuteroltreated animals (28) led to the suggestion that the muscle hypertrophy induced by the ␤ 2 -agonist is exclusively dependent on the inhibiton of protein degradation.…”