Tissue reaction and biodegradation of implanted cross‐linked high amylose starch in rats

Abstract

The biocompatibility and degradation characteristics of cross-linked high amylose starch (Contramid were investigated in rats over 4 months. Contramid pellets (3-mm diameter and thickness) obtained by direct compression, were implanted subcutaneously and intramuscularly. On sequential time points, macroscopic observations of implantation sites were performed and tissue samples were removed, fixed, and histologically evaluated. No macroscopic inflammatory reaction was observed with Contramid.. Upon histologic examination, inflammatory reaction produced by Contramid was moderate and restricted to implantation sites. The sequence of inflammatory events with Contramid was similar regardless of implantation site. Degradation of Contramid pellets was characterized by fragmentation with formation of fibrovascular septa and phagocytosis by macrophages. Finally Contramid was mostly absorbed by the end of the 4-month period and substituted by adipocytes. It has been demonstrated that Contramid is a biocompatible and absorbable material.

Influence of anti‐washout agents on the rheological properties and injectability of a calcium phosphate cement

“…The present reports showed that starch was a biocompatible and bioabsorbable material. 22,23 The cement with modified starch showed the best antiwashout property among the anti-washout agents used in this study. This may be caused by the modified starch formed viscous gel when gelatinized in water, and physically adsorbed on the surface of the CPC particles, which immobilized the CPC particles and restrain the penetration of liquid into the cement paste.…”

Water Soluble Polymers for Pharmaceutical Applications

“…Starch is a natural polymer which has widespread application ranging from a simple filler or binder [199] to a more functional ingredient in the formulation of capsules [200], coatings [201], subcutaneous implants [202], and tablets. In tablets, starch has been mainly used as a binder, diluents, disintegrant and also as a sustained release agent in matrix systems [203,204].…”

Intravaginal Delivery Approaches for Contraception: An Overview with Emphasis on Gels

“…It has various practical applications such as a simple binder (76) or as an excipient in the preparation of various formulations including capsules (77), tablets (78), coatings (79) and subcutaneous implants (80). Starch possesses hydrophilic character due to its structure having hydroxyl functional groups.…”