Tissue repair strength using chitosan adhesives with different physical‐chemical characteristics

Barton, Matthew; Morley, John W.; Mahns, David A.; Mawad, Damia; Wuhrer, Richard; Fania, David; Frost, Samuel J; Loebbe, Christian; Lauto, Antonio

doi:10.1002/jbio.201300148

Cited by 27 publications

(16 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These results indicate that elastic and unbinding forces of polymer chains still occur in the irradiated adhesive, enhancing the adhesive toughness. A previous study showed that the Young's modulus of the rose bengal-chitosan adhesive is unchanged when it is laser irradiated, 21 suggesting that the laser does not crosslink the bulk of the adhesive; our results also point out that the laser irradiation does not noticeable alter the adhesive rigidity.…”

Section: Gecko-inspired Bioadhesive Sj Frost Et Alsupporting

confidence: 67%

“…The solution dried up losing~90% of the water content and becoming a thin film, which was insoluble in water and did not swell macroscopically. 20,21 The film preparation took typically 3 weeks under clean conditions, atmospheric pressure and temperature of 25°C. The rose bengal -chitosan film was then carefully detached from the plate without damage; it measured 4 × 3 cm and had a thickness of 28 ± 3 μm.…”

Section: Adhesive Fabricationmentioning

confidence: 99%

“…The maximum load at which the stumps separated (80% load drop) was recorded and the repair strength estimated by dividing the max load to the surface area of the adhesive. 21 …”

Section: Repair Strengthmentioning

confidence: 99%

See 2 more Smart Citations

Gecko-inspired chitosan adhesive for tissue repair

et al. 2016

Self Cite

View full text Add to dashboard Cite

The advent of nanotechnology has opened the possibility of fabricating nanoscopic pillars on the surface of polymeric films mimicking the Gecko's foot, in an attempt to increase their adhesive capabilities enhanced by van der Waals forces. However, these forces are considerably weakened in a wet physiological environment. To circumvent this loss in force, current biocompatible adhesives with nanopillars require complex multiple-step fabrication, including an extra layer of adhesive coating to stabilize tissue bonding under physiological conditions. In this report, we describe a simple one-step fabrication process of a single-layer chitosan film that has pillars with base diameter in the range of 100-600 nm and a height of~70 nm. The nanostructured adhesive is laser-bonded to tissue and does not require pillar coating to enhance bonding in water. In comparison with a 'flat' adhesive (without pillars), the nanostructured adhesive bonded significantly stronger to tissue under either stress or pressure. Atomic force spectroscopy also confirmed the superior bonding capability of the nanostructured adhesive. This study demonstrates a one-step fabrication technique to produce a monolayer gecko-inspired adhesive that is biocompatible and bonds effectively to tissue.

show abstract

Section: Gecko-inspired Bioadhesive Sj Frost Et Alsupporting

confidence: 67%

Section: Adhesive Fabricationmentioning

confidence: 99%

See 1 more Smart Citation

Gecko-inspired chitosan adhesive for tissue repair

et al. 2016

Self Cite

View full text Add to dashboard Cite

show abstract

“…Functionally, RB-chitosan adhesive was associated with a quicker and more pronounced recovery of grip force when compared to the suture-repair. Moreover, they reported that chitosan adhesive films have also been shown to strongly adhere to sheep intestine without any chemical modification to chitosan [ 176 ]. In this study, we continued to investigate chitosan adhesive films and explored the impact on tissue repair strength and tensile strength characteristics of four types of adhesive films based on chitosan with different molecular weights and degrees of deacetylation.…”

Section: Tissue Adhesives Based On Chitin and Chitosanmentioning

confidence: 99%

RETRACTED: Chitin, Chitosan, and Its Derivatives for Wound Healing: Old and New Materials

Aso

Izumi

Osaki

et al. 2015

JFB

328

116

View full text Add to dashboard Cite

Chitin (β-(1-4)-poly-N-acetyl-d-glucosamine) is widely distributed in nature and is the second most abundant polysaccharide after cellulose. It is often converted to its more deacetylated derivative, chitosan. Previously, many reports have indicated the accelerating effects of chitin, chitosan, and its derivatives on wound healing. More recently, chemically modified or nano-fibrous chitin and chitosan have been developed, and their effects on wound healing have been evaluated. In this review, the studies on the wound-healing effects of chitin, chitosan, and its derivatives are summarized. Moreover, the development of adhesive-based chitin and chitosan are also described. The evidence indicates that chitin, chitosan, and its derivatives are beneficial for the wound healing process. More recently, it is also indicate that some nano-based materials from chitin and chitosan are beneficial than chitin and chitosan for wound healing. Clinical applications of nano-based chitin and chitosan are also expected.

show abstract

“…Laser‐activation has the advantage of bonding to tissue through a non‐contact, aseptic mechanism. Chitosan adhesive films were investigated to explore the impact on the tissue repair strength and tensile strength characteristics . The same group developed photochemical‐tissue bonding using rose Bengal integrated into a chitosan bioadhesive as an alternative nerve repair device that removes the need for sutures .…”

Section: Tissue Therapymentioning

confidence: 99%

Modern trends in biophotonics for clinical diagnosis and therapy to solve unmet clinical needs

Krafft

2016

Journal of Biophotonics

View full text Add to dashboard Cite

This contribution covers recent original research papers in the biophotonics field. The content is organized into main techniques such as multiphoton microscopy, Raman spectroscopy, infrared spectroscopy, optical coherence tomography and photoacoustic tomography, and their applications in the context of fluid, cell, tissue and skin diagnostics. Special attention is paid to vascular and blood flow diagnostics, photothermal and photodynamic therapy, tissue therapy, cell characterization, and biosensors for biomarker detection.

show abstract

Tissue repair strength using chitosan adhesives with different physical‐chemical characteristics

Cited by 27 publications

References 22 publications

Gecko-inspired chitosan adhesive for tissue repair

Gecko-inspired chitosan adhesive for tissue repair

RETRACTED: Chitin, Chitosan, and Its Derivatives for Wound Healing: Old and New Materials

Modern trends in biophotonics for clinical diagnosis and therapy to solve unmet clinical needs

Contact Info

Product

Resources

About